Navigation Links
Epigenetic breakthrough bolsters understanding of Alzheimer's disease
Date:8/17/2014

A team led by researchers at the University of Exeter Medical School and King's College London has uncovered some of the strongest evidence yet that epigenetic changes in the brain play a role in Alzheimer's disease.

Epigenetic changes affect the expression or activity of genes without changing the underlying DNA sequence and are believed to be one mechanism by which the environment can interact with the genome. Importantly, epigenetic changes are potentially reversible and may therefore provide targets for the development of new therapies.

Globally, more than 26 million people are currently affected by Alzheimer's Disease. As this number grows in line with an increasingly aging population, the need to identify new disease mechanisms is more important than ever. Post-mortem examinations have revealed much about how Alzheimer's damages the brain, with some regions, such as the entorhinal cortex, being particularly susceptible, while others, such as the cerebellum, remain virtually unscathed. However, little is yet known about how and why the disease develops in specific brain regions.

The current study found that chemical modifications to DNA within the ANK1 gene are strongly associated with measures of neuropathology in the brain. The study, published in Nature Neuroscience, found that people with more Alzheimer's disease-related neuropathology in their brains had higher levels of DNA modifications within the ANK1 gene. The finding was particularly strong in the entorhinal cortex, and also detected in other cortical regions affected by the disease. In contrast, no significant changes were observed in less affected brain regions or blood.

Professor Jonathan Mill, of the University of Exeter Medical School and King's College London, who headed the study, said: "This is the strongest evidence yet to suggest that epigenetic changes in the brain occur in Alzheimer's disease, and offers potential hope for understanding the mechanisms involved in the onset of dementia. We don't yet know why these changes occur it's possible that they are involved in disease onset, but they may also reflect changes induced by the disease itself."

Dr Katie Lunnon, first author on the study, from the University of Exeter Medical School, added: "It's intriguing that we find changes specifically in the regions of the brain involved in Alzheimer's disease. Future studies will focus on isolating different cell-types from the brain to see whether these changes are neuron-specific."

Dr Simon Ridley, Head of Research at Alzheimer's Research UK, the UK's leading dementia research charity, who also provided funding for the study said:

"We know that changes to the DNA code of certain genes are associated with an increased risk of developing Alzheimer's disease. Investigating how epigenetic changes influence genes in Alzheimer's is still a relatively new area of study. The importance of understanding this area of research is highlighted by the fact that epigenetic changes have been associated with development of other diseases, including cancer.

"This innovative research has discovered a potential new mechanism involved in Alzheimer's by linking the ANK1 gene to the disease. We will be interested to see further research into the role of ANK1 in Alzheimer's and whether other epigenetic changes may be involved in the disease."

"Alzheimer's affects millions of people worldwide and we need pioneering research to understand exactly why the disease occurs. Alzheimer's Research UK is helping to fund research which will take us a step closer to understanding and defeating this devastating disease."


'/>"/>
Contact: Liz French
pressoffice@exeter.ac.uk
44-139-272-2062
University of Exeter
Source:Eurekalert

Related biology news :

1. Epigenetic signatures direct the repair potential of reprogrammed cells
2. Epigenetics and epidemiology -- hip, hype and science
3. Not by DNA alone: How the epigenetics revolution is fostering new medicines
4. Scientists discover an epigenetic cause of osteoarthritis
5. Sick from stress? Blame your mom… and epigenetics
6. Epigenetic causes of prostate cancer
7. Scientists uncover mechanism by which plants inherit epigenetic modifications
8. Study finds epigenetics, not genetics, underlies homosexuality
9. More than 3,000 epigenetic switches control daily liver cycles
10. Researchers identify new components of the epigenetic code for honey bee development
11. Epigenetics shapes fate of brain vs. brawn castes in carpenter ants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... -- Socionext Inc., a global expert in SoC-based imaging and computing solutions, ... which features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ... will be showcased during the upcoming Medtec Japan at Tokyo Big ... Las Vegas Convention Center April 24-27. ... Click here for an image of ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
(Date:4/6/2017)... 6, 2017 Forecasts by Product ... Readers, by End-Use (Transportation & Logistics, Government & Public ... & Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business ... Are you looking for a definitive report on ... ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... Indiana (PRWEB) , ... April 18, 2017 , ... Alisa ... 2017 Distinguished Alumni Awards from the Purdue College of Pharmacy in Lafayette, Indiana. ... Purdue Pharmacy Program for achievements in their careers and other scientific endeavors. , ...
(Date:4/19/2017)... ... April 19, 2017 , ... ... A-1 financing round. This event adds to several other early achievements at ThermaGenix, ... and Scientific Teams. , ThermaGenix will use proceeds from the Series ...
(Date:4/19/2017)... PORTLAND, Oregon and PUNE, India , April 19, ... titled, "Membrane Microfiltration Market: Global Opportunity Analysis and Industry Forecast, 2014-2022 ," ... to garner $12,858 million by 2022, registering a CAGR of 9.6% from 2016 ... ... ...
(Date:4/19/2017)... , April 19, 2017 Veracyte, ... announced that it will report its first quarter ... May 3, 2017. Following the announcement, Veracyte,s management will host ... Eastern Time to discuss the company,s financial results and ... subsequent replay may be accessed by visiting Veracyte,s website at  ...
Breaking Biology Technology: