Navigation Links
Enzyme prevents fatal heart condition associated with athletes

Scientists have discovered an important enzyme molecule that may prevent fatal cardiac disorders associated with cardiac hypertrophy the leading cause of sudden cardiac death in young athletes.

Cardiac hypertrophy is a disease of the heart muscle where a portion of the tissue is thickened without any obvious cause. It is commonly linked to high blood pressure (hypertension) and excessive exercises and results in a shrinking of the heart chamber and a reduction of its blood-pumping volume.

The condition is also associated with fatal cardiac disorders related to irregular heart beats (arrhythmias), leading to millions of deaths worldwide each year, and is perhaps the most well-known cause of sudden cardiac arrest in young sports people.

The researchers used laboratory experiments and computer simulations to show that the enzyme MKK4 is involved in preventing arrhythmias. They believe it does this by modifying another protein, connexion, which forms an electrical bridge between adjacent heart cells to ensure the conduction of electrical activity across the heart as an excitation wave, triggering synchronised mechanical contraction of the heart with a regular heartbeat rhythm.

The multidisciplinary team, writing in The Journal of Biological Chemistry, found that loss of the MKK4 protein disrupts the spatial distribution of connexin, resulting in reduced and non-uniform electrical coupling between heart cells.

This causes a fragmented excitation wave in the heart, leading to uncoordinated heart muscle contraction and irregular heart rhythm. As a result, the heart loses its power to pump blood efficiently, causing disability or sudden cardiac death.

"Using experimental measurements together with detailed computer models, we were able to simulate the electrical activity in cardiac tissue with disrupted electrical coupling between adjacent cardiac cells," said Dr Xin Wang, in Manchester's Faculty of Life Science.

"The information generated from this study will help us to identify whether the MKK4 enzyme could become a therapeutic target for the treatment of cardiac arrhythmias in association with cardiac hypertrophy."

Co-author Professor Henggui Zhang, a biophysicist in Manchester's School of Physics and Astronomy, added: "This research means it would be possible to identify the most important factor behind the sudden cardiac death associated with cardiac hypertrophy, which can affect people of any age with hypertension and also healthy well-trained athletes."


Contact: Aeron Haworth
University of Manchester

Related biology news :

1. UT Southwestern research reveals how cancer-driving enzyme works
2. Nano fit-ness: Helping enzymes stay active and keep in shape
3. Anna-Kaisa Niemi awarded 2011 Genzyme/ American College of Medical Genetics Foundation Fellowship
4. Enzyme can steer cells or possibly stop them in their tracks
5. Production of mustard oils: On the origin of an enzyme
6. Study analyzes role of PARP enzyme in eukaryotes
7. Enzymes from garden compost could favour bioethanol production
8. Enzyme enhances, erases long-term memories in rats
9. DSM and Codexis Sign Enzyme Supply Agreement
10. 1 group of enzymes could have a positive impact on health, from cholesterol to osteoporosis
11. Team looks to the cow rumen for better biofuels enzymes
Post Your Comments:
(Date:10/29/2015)... 29, 2015  Connected health pioneer, Joseph C. ... of technology-enabled health and wellness, and the business opportunities ... The Internet of Healthy Things . Long ... even existed, Dr. Kvedar, vice president, Connected Health, Partners ... delivery, moving care from the hospital or doctor,s office ...
(Date:10/29/2015)... 2015 Today, LifeBEAM , a ... 2XU, a global leader in technical performance sports ... with advanced bio-sensing technology. The hat will allow ... key biometrics to improve overall training performance. As ... will bring together the most advanced technology, extensive ...
(Date:10/27/2015)... -- Munich, Germany , October ... automatically maps data from mobile eye tracking videos created ... that they can be quantitatively analyzed with SMI,s analysis ... , October 28-29, 2015. SMI,s Automated Semantic Gaze ... tracking videos created with SMI,s Eye Tracking Glasses ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... Nov. 24, 2015  Asia-Pacific (APAC) holds the ... (CRO) market. The trend of outsourcing to low-cost ... but higher volume share for the region in ... however, margins in the CRO industry will improve. ... ( ), finds that the market ...
(Date:11/24/2015)... -- Cepheid (NASDAQ: CPHD ) today announced that ... and invited investors to participate via webcast. ... 1, 2015 at 11.00 a.m. Eastern Time --> ... 1, 2015 at 11.00 a.m. Eastern Time --> ... NY      Tuesday, December 1, 2015 at 11.00 ...
(Date:11/24/2015)... 24, 2015 /CNW/ - iCo Therapeutics ("iCo" or "the ... results for the quarter ended September 30, 2015. ... dollars and presented under International Financial Reporting Standards ... ," said Andrew Rae , President & ... are not only value enriching for this clinical ...
(Date:11/24/2015)... ... 24, 2015 , ... International Society for Pharmaceutical Engineering (ISPE) ... annual events for pharmaceutical manufacturing: 2015 Annual Meeting. The conference took place in ... largest number of attendees in more than a decade. , “The 2015 ...
Breaking Biology Technology: