Navigation Links
Enzyme necessary for development of healthy immune system
Date:12/22/2009

id the research team expected to find widespread defects in development when they knocked out the dCK enzyme in the mice.

"Surprisingly, we found that the gene had a highly specific role in the development of organs crucial to a normally-functioning immune system," Austin said. "Mice lacking the dCK enzyme have thymuses that are reduced in size by 90-fold. That defect in thymus size resulted in mice having 5 to 13-times fewer lymphocytes circulating throughout the body."

This finding is part of research that was launched several years ago and represents the third significant discovery. The first was the development of a new probe for PET scanning created by modifying a common chemotherapy drug, an advance that allowed UCLA researchers to model and measure the immune system in action and monitor response to new therapies.

Researchers created the molecule, called FAC, by slightly altering the molecular structure of gemcitabine, a chemotherapy drug that is activated by dCK activity. They added a radiolabel so the cells that take in the probe can be seen during PET scanning.

The probe was based on a fundamental cell biochemical pathway called the DNA Salvage Pathway, which includes dCK. All cells use this biochemical pathway to different degrees. But in lymphocytes, which are the active players in the adaptive immune system, the pathway is activated at very high levels. Because of that, the probe accumulates at high levels in those cells, said Dr. Owen Witte, director of the Broad Stem Cell Research Center and a Howard Hughes Medical Institute investigator.

That work was published June 8, 2008 in the journal Nature Medicine.

The second significant finding was the development of a non-invasive approach that may allow doctors to evaluate a tumor's response to a drug before prescribing the treatment, enabling physicians to personalize therapy to the patient's unique biochemistry.

In this study, the U
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Newly identified enzymes help plants sense elevated CO2 and could lead to water-wise crops
2. Tiny particles can deliver antioxidant enzyme to injured heart cells
3. Genencor Wins The American Institute of Chemical Engineers (AIChE) Sustainable Energy Award For Accellerase(R) Cellulosic Ethanol Enzymes
4. UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin
5. Scientists are first to observe the global motions of an enzyme copying DNA
6. New artificial enzyme safer for nature
7. Developing enzymes to clean up pollution by explosives
8. Enzyme may be a key to Alzheimers-related cell death
9. Sakayu Shimizu of Kyoto University recipient of 2009 Enzyme Engineering Award
10. Rutgers-Camden developing enzyme function database
11. Joint research into an enzyme that causes genetic diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... Before the colonial era, 100,000s of people lived on ... cultures manipulated fire to control the availability of plants ... tribes continue to use fire to maintain desired habitat ... the U.S. Forest Service,s Pacific Southwest Station, will lead ... National Wildfire Refuge during the Ecological Society of America,s ...
(Date:7/25/2014)... from 25 countries and 35 states will attend ... Genetics Society of America (GSA) next week at ... will feature close to 500 presentations (including 70 ... gene expression and regulation, functional genomics, chemical biology ... a variety of diseases. , Of special ...
(Date:7/25/2014)... (SB) is a complex congenital central nervous system ... of the neural tubes during the embryonic phase. ... and fecal incontinence and neurocognitive retardation. Such problems ... of life. Researchers at Ankara Physical Medicine and ... functional performance in children with SB, using the ...
Breaking Biology News(10 mins):Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3Yeast meeting to showcase latest breakthroughs in genetics and molecular biology 2
... of an fMRI (functional magnetic resonance imaging) technique, ... Medicine have, for the first time, visualized the ... human brain. , Their work, performed at Penn's ... of psychological stress -- which will pave the ...
... some protection to the heart from injury even if ... attack, Jefferson Medical College researchers report. , Walter Koch, ... the Department of Medicine at Jefferson Medical College of ... that the drug Darbepoietin alpha would protect the ischemic ...
... two bacteria that cause significant damage to pig and ... are now analysing the results in an attempt to ... vaccines and diagnostic kits against the bacteria. , Mycoplasma ... pig-breeding industry US$200 million each year. Mycoplasma synoviae is ...
Cached Biology News:Research Permits First-Ever Visualization of Psychological Stress in the Human Brain 2
(Date:7/24/2014)... July 24, 2014 Research and Markets ... Genomics and Proteomics Analytical Instruments Market 2014-2018" report ... Genomics is the study of the ... of the structure and functions of proteomes or sets ... and technology. Genomics involves the mapping of genes and ...
(Date:7/24/2014)... PARK, Calif. , July 24, 2014 ... seven-year contract with the National Institute of Allergy and ... Health, to conduct preclinical development of potential therapies for ... of drugs to treat HIV and AIDS and the ... well as microbicides for preventing sexual transmission of HIV. ...
(Date:7/24/2014)... CA (PRWEB) July 24, 2014 Three ... be semi-finalists in Livestrong’s Big C Competition. Out of ... are each headed to the semi-final round. In this ... exclusive three-month accelerator program, complete with mentoring from thought-leaders ... , As part of the angelMD commitment to the ...
(Date:7/24/2014)... , July 24, 2014  Neogen Corporation (Nasdaq: ... forecasts of its potential revenue from new rodenticide research ... investors and analysts on July 22, 2014, Neogen,s CEO ... regarding this research. "It was my intent ... the potential of a new type of rodenticide, but ...
Breaking Biology Technology:Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 33 angelMD Startups Make Livestrong Big C Semi-finals 2Neogen comments on SenesTech 2
... for the Study of ... DNA-Protein Interactions, ... launch of its Imprint(TM) Chromatin,Immunoprecipitation Kit for epigenetic research,( http://www.sigma.com/chip ... Immunoprecipitation, including columns and reagents,for DNA purification as well as ...
... April 16 Medarex, Inc.,(Nasdaq: MEDX ) ... that suggest a,potential association between higher doses of ... control and prolonged,progression-free survival in patients with relapsed ... 1/2 trial were presented at the,Annual Meeting of ...
... Masimo (Nasdaq:,MASI), the inventor of Pulse CO-Oximetry ... Atom Medical Corporation, a leading global manufacturer ... Rainbow SET Pulse,CO-Oximetry into its current and ... Masimo technology more than 10 years ago, ...
Cached Biology Technology:Sigma(R) Launches Innovative ChIP Kit Technology For Epigenetic Research 2Sigma(R) Launches Innovative ChIP Kit Technology For Epigenetic Research 3Medarex Reports Phase 1/2 Clinical Data of MDX-060 in Lymphoma at American Association for Cancer Research Meeting 2Medarex Reports Phase 1/2 Clinical Data of MDX-060 in Lymphoma at American Association for Cancer Research Meeting 3Atom Medical Adopts Masimo Rainbow SET Technology 2Atom Medical Adopts Masimo Rainbow SET Technology 3Atom Medical Adopts Masimo Rainbow SET Technology 4
... Savant SpeedVac Concentrators set the standard for centrifugal ... uses a combination of centrifugal force, heat and ... run., SC110A comes equipped with:, , TEFLON-coated ... , Three ...
... The first SpeedVac to have active, real-time ... SpeedVac System is the worlds first, fully ... can be stacked together to form an ... benchspace. It is also the first SpeedVac ...
... RC Standard Bio for vacuum concentrator/centrifugal ... molecular biology and biochemistry for rapid and ... systems can be expanded with pumps, different ... of rotors (eliminating sample loss by transfer), ...
... dedicated concentrator for efficient drying of small ... integrated system combines the SpeedVac™ Concentrator and ... automatic pump and rotor control, and dual ... heater time), makes the DNA120 indispensable in ...
Biology Products: