Navigation Links
Enzyme may be a key to Alzheimer's-related cell death
Date:10/7/2009

WEST LAFAYETTE, Ind. - A Purdue University researcher has discovered that the amount of an enzyme present in neurons can affect the mechanism thought to cause cell death in Alzheimer's disease patients and may have applications for other diseases such as stroke and heart attack.

Sandra Rossie, a professor of biochemistry, found that increasing the amount of protein phosphatase 5, or PP5, in rat neural cells resulted in less cell death associated with reactive oxygen species, which chemically damage cell molecules. Conversely, decreasing PP5 caused greater cell death. The results of Rossie's study are published in the early online version of the Journal of Neurochemistry.

Alzheimer's, a degenerative neurological disease affecting around 5 million people, results in memory loss and dementia. One theory on the cause of Alzheimer's is that overproduction of certain forms of amyloid beta protein by neurons leads to the generation of reactive oxygen species, which activate stress pathways.

"If stress pathways remain active for a prolonged period, the cell will die," Rossie said.

Rossie's lab found that PP5 overexpression prevents neuronal death by amyloid beta and shuts off the stress pathways. When reactive oxygen that wasn't created by amyloid beta was used on the cells, the results were the same. In contrast, neurons with reduced PP5 are more sensitive to death caused by amyloid beta.

"That suggests to us that PP5 protects neurons from cell death induced by reactive oxygen species, not just the presence of amyloid beta," Rossie said. "This means that PP5 may protect against other health problems involving reactive oxygen species as well, such as stroke and heart attacks."

It is possible, Rossie said, that finding a way to increase PP5 activity could help prevent the loss of neurons by amyloid beta.

Rossie said PP5 also could play a role in inhibiting other responses of neurons to amyloid beta. Her lab will work to determine which pathways PP5 affects, and which of those is most responsible for neural protection by PP5.


'/>"/>

Contact: Brian Wallheimer
bwallhei@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert  

Related biology news :

1. Sakayu Shimizu of Kyoto University recipient of 2009 Enzyme Engineering Award
2. Rutgers-Camden developing enzyme function database
3. Joint research into an enzyme that causes genetic diseases
4. Corrective genes closer thanks to enzyme modification
5. Childrens Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging
6. Enzyme doesnt act alone in atrial fibrillation
7. Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms
8. Scientists uncover mode of action of enzyme linked with several types of cancer
9. Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine
10. How an enzyme tells stem cells which way to divide
11. New book, Untangling the Double Helix, explores enzymes responsible for maintaining genome integrity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Enzyme may be a key to Alzheimer's-related cell death
(Date:4/3/2017)...  Data captured by IsoCode, IsoPlexis Corporation,s ... statistically significant association between the potency of ... objective response of cancer patients post-treatment. The ... cancer patients will respond to CAR-T cell ... to improve both pre-infusion potency testing and cell ...
(Date:3/30/2017)... The research team of The Hong Kong Polytechnic University ... adopting ground breaking 3D fingerprint minutiae recovery and matching technology, pushing ... for use in identification, crime investigation, immigration control, security of access ... ... A research team led by Dr Ajay ...
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... , ... April 27, 2017 , ... ... for digital pathology, today announced their digital pathology technology has the potential to ... by five medical centers in The Netherlands as part of the 2017 ...
(Date:4/27/2017)... California (PRWEB) , ... April 27, 2017 , ... ... new infographic explaining why mass flow controllers based on capillary thermal mass flow ... industrial gas mass flow control applications. Over 80% of all industrial processes—such ...
(Date:4/27/2017)... -- Kinexum, a distinguished resource for research, development and commercialization ... Thomas C. Seoh as President and CEO. Mr. ... who becomes Executive Chairman and will continue to serve ... Thomas Seoh commented, "I am excited and ... the firm,s remarkable team of life science professionals, all ...
(Date:4/26/2017)... ... April 26, 2017 , ... Baltimore bio tech firm, ... security screening solution at the National Postal Forum 2017 in Baltimore, Maryland, May ... highly accurate, easy to use and low cost threat detection solution for government ...
Breaking Biology Technology: