Navigation Links
Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine
Date:6/2/2009

Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD). The team, co-led by Judith Bond, Ph.D., Distinguished Professor and Chair of Biochemistry and Molecular Biology at Penn State College of Medicine, and Daniel Lottaz, Department of Rheumatology and Clinical Immunology at the University of Bern, Switzerland, could potentially lead to therapies to help the half-a-million Americans affected by ulcerative colitis and Crohn's disease, collectively referred to as IBD.

The enzyme, coded for by the MEP1A gene, is a zinc-containing metalloprotease called meprin, and is abundant in the intestine. A protease is an enzyme that breaks down proteins in the body.

Researchers at Penn State College of Medicine studied the role of meprin in IBD using genetically altered mice lacking the ability to produce the enzyme in collaboration with colleagues in Switzerland who studied the enzyme in IBD patients. Meprin is abundant in the latter part of the small intestine, or terminal ileum, and is also present in the large intestine at a lower level. The European researchers found an alteration in the meprin gene that correlated with IBD. They then compared the levels of meprin in affected and unaffected sections of colons from IBD patients and from healthy people. The amount of enzyme in the IBD patient's inflamed colon was significantly lower than that in normal colon sections. The researchers concluded that their findings strongly correlate the severity of inflammation associated with both Crohn's disease and ulcerative colitis with low meprin levels.

"This discovery is a major advance in understanding the genetic control of inflammation, and of ulcerative colitis and Crohn's disease in particular," Bond said. She discovered meprin more than 25 years ago while at
'/>"/>

Contact: Matthew G. Solovey
msolovey@hmc.psu.edu
717-531-0003 x287127
Penn State Hershey Medical Center, Penn State College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. How an enzyme tells stem cells which way to divide
2. New book, Untangling the Double Helix, explores enzymes responsible for maintaining genome integrity
3. Margarita Saenz, M.D. is recipient of Genzyme/ACMGF Fellowship in Biochemical Genetics
4. A missing enzyme conveys major heart protection in pre-clinical work
5. New drug agent knocks out multiple enzymes in cancer pathway
6. Gladstone scientists reveal key enzyme in fat absorption
7. Commercial yeasts upgraded with an enzyme for biofuel production
8. Duke software dramatically speeds enzyme design
9. Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
10. Researchers find pathway and enzyme unique to tularemia organism
11. Structure of enzyme against chemical warfare agents determined
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... , Aug. 12, 2015   MedNet Solutions ... the entire spectrum of clinical research, is proud to ... the company,s comprehensive SaaS-based eClinical technology platform, has led ... the first two quarters of 2015.   Q2 2015 ... largest quarters measured by contract value sold in the ...
(Date:8/10/2015)... and TELTOW, Germany , August 10, ... (SMI), a world leader in Eye Tracking Technology for ... its OEM Eye Tracking Platform for integration into all ... contains reference designs for seamless integration of eye tracking ... reality HMDs and augmented reality smart glasses. Omnivision,s leading ...
(Date:8/5/2015)... According to a new market ... Services, Vertical (BFSI, Airport, IT & Telecom, Utilities, Education, ... to 2020", published by MarketsandMarkets, defines and segments the ... segments. The global PIAM Market is estimated to grow ... 2019, at a CAGR of 14.9 % from 2014 ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4
... COLD SPRING HARBOR, N.Y. (Thurs., Oct. 1, 2009) ... choice for understanding where and when genes are expressed in ... physiological or environmental conditions. Recent discoveries have revolutionized our ... active in a much wider set of biological processes than ...
... Spatial Integrated Systems, Inc. ("SIS"), a leader in ... digital 3D data capture and processing technologies, announced ... been published for "system and method for generating ... No. US2009/0169095A1. , "We are pleased that our ...
... BATON ROUGE For Sophie Warny, LSU assistant professor of ... Natural Science, years of patience in analyzing Antarctic samples with ... and colleagues from around the world now have proof of ... 15.7 million years ago and lasted for a few thousand ...
Cached Biology News:Cold Spring Harbor Protocols features RNA analysis methods 2Spatial Integrated Systems, Inc. Files Patent Application 2Algae and pollen grains provide evidence of remarkably warm period in Antarctica's history 2Algae and pollen grains provide evidence of remarkably warm period in Antarctica's history 3Algae and pollen grains provide evidence of remarkably warm period in Antarctica's history 4
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... Park ... additive manufacturing on Sept. 17, 2015 at 9am PST. The webinar will focus on ... More popularly known as 3D printing, additive manufacturing is a broad term that encompasses ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... systems, analytical testing, education and consulting services for the medical device sector, ... products/processes development, design control, validation, quality assurance and regulatory compliance. Avarent will ...
(Date:9/2/2015)... 2015 Research and Markets ... PharmaBiotech,s new report "Gene Therapy - Technologies, Markets ... markets for gene therapy are difficult to estimate as ... it is marketed in China ... years 2014-2024. The estimates are based on epidemiology of ...
(Date:9/2/2015)... Australian prostate cancer technology company Minomic International Ltd has ... science that uses its patented antibody. The ... cancer diagnostic test known as MiCheck® next year, was ... peer-reviewed Australian Museum Eureka Science Prize for Excellence ... is awarded for ground breaking research that has only ...
Breaking Biology Technology:Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 2Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 3Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7Global Gene Therapy Market Study 2015-2024 - Technologies, Markets and Companies Analysis 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3
... (Nasdaq: DCGN ) today report the discovery of ... genome (SNPs) that,regulate one of the principle motors of ... have a genome-wide impact on the rate of,recombination -- ... formation,of eggs and sperm. Recombination is largely responsible for ...
... leading global,full-service contract research organization, announced it has ... Pharmacology., Dr. Wei joins Medpace with extensive ... phase cardio-metabolic studies. He will consult,with sponsors on ... which studies merit inclusion in the programs and ...
... -- Max Nutrition Inc.,(OTC Bulletin Board: MXNU; the ... share exchange (the "Closing") pursuant to an Agreement,and ... a,Delaware corporation ("ASPI"). Pursuant to the Agreement, ASPI ... Gansu Biology Science and,Technology Stock Co., Ltd ("GDBS") ...
Cached Biology Technology:deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women 2deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women 3deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women 4Medpace Hires Clinical Pharmacologist, Jim Wei, MD, PhD 2Max Nutrition, Inc. Completes Share Exchange with American Spring Pharmaceutical, Inc. 2
All serum is collected from adult animals aged 6 months or older. Certified U.S. orgin. Pricing: $35/unit for 1 - 10 units...
Natural Mouse Laminin is purified from the Engelbreth-Holm-Swarm (EHS) sarcoma and is provided in Tris-buffered saline....
... • Guinea Pig serum is collected from ... N-02: Citrate N-04: Heparin ... Potassium Oxalate N-10: EDTA (Na) ... N-07: CPD N-09: K3EDTA ...
Request Info...
Biology Products: