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Enzyme enhances, erases long-term memories in rats
Date:3/4/2011

memory enhancement. Conversely, introducing a mutant inactive form of the enzyme, that replaced the naturally occurring one, erased the memory much as the chemical blocker did.

These effects applied generally to multiple memories stored in the targeted brain area raising questions about how specific memories might be targeted in any future therapeutic application.

The researchers turned up a clue that may hold the beginning of an answer.

"One explanation of the memory enhancement is that PKMzeta might go to some synapses, or connections between brain cells, and not others," said Sacktor. "Overexpressed PKMzeta may be selectively captured by molecular tags that mark just those brain connections where it's needed likely synapses that were holding the memory from the training."


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Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert  

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