Navigation Links
Enzyme alerts cell's powerful army to repair DNA damage
Date:9/5/2007

ANN ARBOR, Mich. Scientists know that inside each cell, a little engine called RNA polymerase II does one essential job: It copies instructions from genes in the nucleus that get carried to production units in the rest of the cell to support our daily needs. Now researchers at the University of Michigan Medical School have shown that RNA polymerase II also constantly scans the cells DNA for damage. When certain types of damage in DNA halt the action of RNA polymerase II, a stress signal is generated that alerts a key tumor-suppressor protein called p53.

The activities of p53, a master protein that responds to DNA damage by marshaling hundreds of genes to repair or eliminate damaged cells, have been the subject of thousands of studies. Mutations in the p53 gene occur in more than half of all cancers.

We have come up with a new paradigm for how cells protect themselves against cancer-producing DNA lesions, says Mats Ljungman, Ph.D., a U-M researcher and lead author of a recent study in the Proceedings of the National Academy of Sciences.

Much is known already about p53, but this adds a significant piece of knowledge about how it is activated, Ljungman adds. He is an associate professor in the Department of Radiation Oncology in the Division of Radiation and Cancer Biology at the U-M Comprehensive Cancer Center and associate professor of Environmental Health Sciences at the U-M School of Public Health.

A commentary in the journal praised the U-M study and urged more attention to RNA polymerases as major sensors for all DNA damage response reactions.

Ljungman says the findings have implications for the study of cancer, aging and neurological diseases. Figuring out precisely how cells detect and repair damage is crucial in understanding what goes wrong in cancer, in which harmful mutations can elude the bodys ability to control cell division.

Finding and repairing DNA lesions is a non-stop job for cell
'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
2. Lack of enzyme turns fat cells into fat burners
3. Scientists find missing enzyme for tuberculosis iron scavenging pathway
4. Novel Enzyme Shows Potential As An Anti-HIV Target
5. Enzyme allows B cells to resist death, leading to leukemia
6. Enzyme shown to help protect genomic stability
7. Researchers report new pro-inflammatory role for anti-inflammatory enzyme
8. Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol
9. Purdue researchers use enzyme to clip DNA wires
10. Enzymes newly discovered role may make it target for arthritis treatment
11. Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... Calif. , Dec. 4, 2014 ... has boosted investments in new testing and inspection ... also given rise to a range of innovative ... the requirements of Generation Y, which is generally ... As a result, product development strategies of test ...
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
(Date:12/3/2014)... -- As part of our commitment to offering the ... announce the release of a new reader that will ... data that they need. The Atlas 2000 ... readers. Many such devices have serious shortcomings when it ... models force users to navigate numerous complicated steps in ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Inception Technologies to Release New Biometric Reader 2
... decade’s worth of statistics, researchers are sounding a new alarm ... , The overall number of syphilis cases in the United ... 2003 perhaps because of a nationwide prevention campaign aimed at ... in this decade. , "The entire nation was ...
... of Americans whose vision is slowly ebbing due to degenerative ... be riding to the rescue. , In a study in ... have been shown to protect the vision of animals with ... afflict humans. The new study appears today (March 28) in ...
... Clinic researchers report that freezing kidney tumors through percutaneous ... candidates for surgery. Their early findings showing short-term ... are published in this month’s issue of Radiology. , ... a high likelihood of a long-term cure. For ...
Cached Biology News:Syphilis rate on rise in US gay, bisexual men 2Stem cell therapy shows promise for rescuing deteriorating vision 2Stem cell therapy shows promise for rescuing deteriorating vision 3Cryoablation -- A new treatment option for some kidney tumor patients 2Cryoablation -- A new treatment option for some kidney tumor patients 3
(Date:12/22/2014)... 2014   Synthetic Biologics, Inc. ... therapies for serious infections and diseases, with ... announced positive topline safety and tolerability results ... SYN-004, the Company,s investigational oral beta-lactamase enzyme ... (C. difficile) infection, antibiotic-associated diarrhea and ...
(Date:12/22/2014)... N.C. , Dec. 22, 2014  Alternative ... announced that it has signed a letter of ... that has developed and patented a nanotechnology-based development ... diagnostics products that enable rapid on-site collection and ... use/abuse and health issues in an immediate, non-invasive ...
(Date:12/22/2014)... Calif. , Dec. 22, 2014  ( www.competitivehealth.com ... CoPatient, an online medical bill review and advocacy service, ... in the FREE WellCard Savings discount health services marketplace. ... bill that was more than they expected to pay. ... reduce health care costs, WellCard Savings is pleased to ...
(Date:12/22/2014)... 22, 2014 ITRA Global, one of ... of commercial real estate, has further expanded its global ... Perth and Brisbane, Western Australia, reports Mylinda Vick, CCIM, ... ITRA Global / ACORPP (Australian Corporate Property and ... company providing property services to a wide range of ...
Breaking Biology Technology:Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5ALNE Announces Intention To Acquire BioTechPharma 2WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2
... Dec. 8 Environmental Tectonics Corporation,s (Amex: ... announced the recent installation of two BARA-MED(R)XD Monoplace hyperbaric ... Oklahoma, USA. The state-of-the-art monoplace chambers are the ... in Oklahoma. , , ...
... Globally To The Surgical Industry. The existing face lift ... incision; however, recently highly renowned Korean cosmetic surgeon, Dr. ... which is a 100% non-incision method. Patients can expect ... any incision done to their face. This method creates ...
... CITY, Calif., Dec. 8 Genomic Health,Inc. (Nasdaq: ... of Ginger L. Graham to its,board of directors. ... CEO of Amylin,Pharmaceuticals, Inc.; a biopharmaceutical company dedicated ... people with diabetes and obesity.,Prior to Amylin, Ms. ...
Cached Biology Technology:Environmental Tectonics Corporation Announces Placement of Two Monoplace Chambers at St. John Wound Center; First Computer-controlled Hyperbaric Chambers in Oklahoma 2Environmental Tectonics Corporation Announces Placement of Two Monoplace Chambers at St. John Wound Center; First Computer-controlled Hyperbaric Chambers in Oklahoma 3Environmental Tectonics Corporation Announces Placement of Two Monoplace Chambers at St. John Wound Center; First Computer-controlled Hyperbaric Chambers in Oklahoma 4100% Non-Incision Cosmetic Surgery, The 'Frame Thread Lift,' Debuts December 14, 2008 At American Academy Of Anti-Aging Medicine In Las Vegas 2100% Non-Incision Cosmetic Surgery, The 'Frame Thread Lift,' Debuts December 14, 2008 At American Academy Of Anti-Aging Medicine In Las Vegas 3Genomic Health Announces Appointment of Ginger Graham to Board of Directors 2Genomic Health Announces Appointment of Ginger Graham to Board of Directors 3
... Radiolabeled Ligands\n\nReceptor-related research has long been enabled ... ligands selected to keep pace with new ... products and services for receptor research and ... If you do not find exactly what ...
... taken from the SMZ line is a Greenough ... and testing. It is available with a choice ... a space-saving compact base (N2GG). This microscope can ... a projector all at the same time giving ...
This is a PYREX replacement Allihn condenser with a 34/45 inner joint on the bottom for the No. CLS3840-S 125mL extractor system. The tubulation O.D. on the condenser is 10mm....
... UNIchip AV-400 contains 400 unique human ... glass slide. The proteins, all intracellular ... classification, are arrayed in quadruplicate for ... a specific chip layout guarantee high ...
Biology Products: