Navigation Links
Environmental exposures may damage DNA in as few as three days
Date:5/17/2009

ATS 2009, SAN DIEGOExposure to particulate matter has been recognized as a contributing factor to lung cancer development for some time, but a new study indicates inhalation of certain particulates can actually cause some genes to become reprogrammed, affecting both the development and the outcome of cancers and other diseases.

The research will be presented on Sunday, May 17, at the 105th International Conference of the American Thoracic Society in San Diego.

"Recently, changes in gene programming due to a chemical transformation called methylation have been found in the blood and tissues of lung cancer patients," said investigator Andrea Baccarelli, M.D., Ph.D., assistant professor of applied biotechnology at the University of Milan. "We aimed at investigating whether exposure to particulate matter induced changes in DNA methylation in blood from healthy subjects who were exposed to high levels of particulate matter in a foundry facility."

Researchers enrolled 63 healthy subjects who worked in a foundry near Milan, Italy. Blood DNA samples were collected on the morning of the first day of the work week, and again after three days of work. Comparing these samples revealed that significant changes had occurred in four genes associated with tumor suppression.

"The changes were detectable after only three days of exposure to particulate matter, indicating that environmental factors need little time to cause gene reprogramming which is potentially associated with disease outcomes," Dr. Baccarelli said.

"As several of the effects of particulate matter in foundries are similar to those found after exposure to ambient air pollution, our results open new hypotheses about how air pollutants modify human health," he added. "The changes in DNA methylation we observed are reversible and some of them are currently being used as targets of cancer drugs."

Dr. Baccarelli said the study results indicate that early interventions might be designed w
'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Page: 1 2

Related biology news :

1. River delta areas can provide clue to environmental changes, Texas A&M prof says
2. River delta areas can provide clue to environmental changes, Texas A&M prof says
3. Students least informed about environmental science are most optimistic
4. Field stations foster serendipitous discoveries in environmental, biological sciences
5. Professor to measure environmental impact of war
6. Environmental cleaning intervention reduces transmission of multidrug-resistant organisms in ICUs
7. Autism Speaks funds $5 million to studies on genetic and environmental risk factors for autism
8. Winners of Tyler environmental prize announced
9. Polar research reveals new evidence of global environmental change
10. NTU seals global partnerships on environmental sciences R&D
11. What we don’t know still hurts us, environmental researchers warn
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... of dementia and affects some 400,000 people in Spain ... One of the reasons for this is the lack ... in nerve transmissions and the loss of memory in ... Institute of Neuroscience at the Universitat Autnoma de Barcelona ... and were able to develop a gene therapy which ...
(Date:4/23/2014)... of social relationships they may be friends, kin, ... From a cognitive perspective, understanding one,s own relationships to ... ("knowing who is nice or not"). Yet, understanding also ... the stage for "political" maneuvers ("knowing who might support ... in the scientific journal Nature Communications . ...
(Date:4/23/2014)... London (April 23, 2014). "I think one can argue that ... well as doing everything else that we canthen we can ... Wigley, one of the world,s foremost climate researchers, in the ... published by SAGE. Refusing to take significant action on climate ... be needed to address the problem, Wigley explains in an ...
Breaking Biology News(10 mins):Loss of memory in Alzheimer's mice models reversed through gene therapy 2Ravens understand the relations among others 2Is nuclear power the only way to avoid geoengineering? 2
... different from what a runner might take on a ... to make life more comfortable for cattle. A ... a pedometer are a few of the tools K-State ... two routine procedures, castration and dehorning. Hans Coetzee, ...
... including nursery and greenhouse producers, landscape services firms, ... during the past two decades, becoming an increasingly ... the Green Industry generated 1.96 million jobs and ... U.S. nursery and greenhouse crops reached $16.9 billion. ...
... the twelfth release in a series of erect-growing, ... Watson) cultivars developed by the University of Arkansas. ... of the Department of Horticulture at the University ... issue of the American Society of Horticultural Science,s ...
Cached Biology News:Veterinarians developing model to help producers, vets make cattle more comfortable 2Veterinarians developing model to help producers, vets make cattle more comfortable 3Results of national nursery survey unveiled 2
(Date:1/15/2014)... IL (PRWEB) January 15, 2014 Look ... find hard-working items for the lab, from fluid handling ... Guaranteed-in-Stock (GIS)—ready to ship when you order. , ... Peristaltic Pumps , from the L/S® model for precise ...
(Date:1/15/2014)... OXFORD, England and SAN JOSE, California ... an international biotechnology company developing antibody-drug conjugates for cancer, today ... its Board of Directors. Dr Reynolds has over 20 years, ... Chief Medical Officer at Seattle Genetics. "I am ...
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
(Date:1/15/2014)... More than 5 million Americans are ... 3 seniors will die with Alzheimer’s or another dementia, ... have shocked many Americans into looking for ways to ... tragic age-related cognitive disorders. Jonathan Weisman, president of Biohack ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2
... Technologies , a high-technology spin-off of the University of ... during the biggest blackout the nation has ever seen. ... Near-simultaneous events were recorded in New York and Michigan ... across the northeastern United States, with the I-Grid recording ...
... Wisconsin companies recently won CIO magazines CIO ... resourcefulness regarding the use of information technology(IT) within their ... Menasha Corp. each won the award, announced in the ... Manpower CIOs are on the cover of the magazine. ...
... a two-year grant from the state Department of Commerce ... which for years trailed their counterparts in Madison in ... up. Thats good news for Milwaukee - which means ... wants to transform itself from an old-line manufacturing burg ...
Cached Biology Technology:Local Company Records Blackout with Web-Based Monitoring System 2Local Company Records Blackout with Web-Based Monitoring System 3Five Wisconsin Non-Tech Companies Win IT Awards 2Five Wisconsin Non-Tech Companies Win IT Awards 3Five Wisconsin Non-Tech Companies Win IT Awards 4Milwaukee research institutions step up the pace for technology transfer 2
... clone d1-174 GenBank Accession Number : ... N-terminal tagged fusion protein corresponding to full ... Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium ... 30% Quality Assurance: routinely evaluated by immunoblot ...
...
X-Gal, 1 g. 5-Bromo-4-chloro-3-indolyl-b-d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: Nucleotides & Enzymes...
Conjugation services for Antibodies, Proteins, Oligos, Peptides, Beads, bioconjugation, antibody-oligonucleotide, LNA peptide, LNA protein, LNA antibody, HRP, Alkaline phosphatase, phycoerythrin, FIT...
Biology Products: