The authors noted that cerebral palsy has been associated with hypoxic brain injury, resulting in "considerable incidence or morbidity." They also noted that exercise has shown to be beneficial to children with CP. However, they also reported that ASC transplantation in animal models of CP has yet to be studied.
The researchers concluded that, compatible with other studies, EE increases endogenous cell migration to an ischemic injury and facilitates functional repair.
"The role of FGF2 as a mediator of the effects of exercise on the brain, and that FGF2 can be induced by physical exercise and regulated in an activity-dependent fashion, raises the possibility that FGF2 is involved in behavioral function," explained Dr. Cho. "We propose that the increase in FGF2 may provide a favorable microenvironment for repair purposes, and thus contribute to functional recovery."
They concluded that a rehabilitative strategy of cell-based therapy coupled with environmental enrichment could be effective for treating CP and other neurological diseases, including adult stroke.
"This study highlights the potential impact that combination therapies, such as stem cell transplantation and rehabilitation, could have on brain disorders, possibly due to their interaction with survival or integration of the implanted cells or to modulation of the host microenvironment," said Prof Stephen Dunnett of Cardiff University's Brain Repair Group, "but it is important to emphasise that such initial observations are a very long way from yet providing a clinical therapy. We still need to understand the mechanisms by which implanted cells and growth factors work together to enhance functional recovery, we need better animal models to test the cells that are directly relevant to the specific human disorder targeted, and there are pr
|Contact: Robert Miranda|
Cell Transplantation Center of Excellence for Aging and Brain Repair