Navigation Links
Environmental enrichment important factor impacting cell transplantation and brain repair
Date:3/27/2013

Putnam Valley, NY. (March. 27, 2013) A team of Korean researchers investigated whether "environmental enrichment" can improve the neurobehavioral function of six week-old mice after transplantation of adipose-derived stem cells (ASCs) to treat hypoxic-ischemic brain injury, and found that brain repair (neurogenesis) was aided in some animals through exercise-induced fibroblast growth factor 2 (FGF2), a strong pro-angiogenic factor.

The post-transplantation environmental enrichment (EE) included use of a running wheel and exposure to "novel objects."

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0633seo.

"FGF2 was synergistically enhanced in the striata of mice treated with EE after ASC transplantation," said study co-author Dr. Sung-Rae Cho of the Yonsei University College of Medicine in Seoul, Korea. "The underlying mechanisms of this synergism included an enhanced repair process, such as higher engraftment of the transplanted ASCs, increased endogenous neurogenesis, and astrocytic activation coupled with the increase in FGF2."

Astrocytes, star-shaped brain cells that are also the most abundant brain cell, perform many functions, including supporting the cells that form the bloodbrain barrier and providing nutrients for nervous system tissue. Multipotent ASCs have been used for promoting angiogenesis (blood vessel growth) and are also known to secrete potentially beneficial growth factors.

"Hypoxic-ischemic brain injury is a major cause of damage to the fetal and neonatal brain," said Dr. Cho. "The majority of affected children demonstrate neurodevelopment impairment. However, cell-based therapy has emerged as a potential treatment. In this study we applied EE in the chronic
'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Effects of environmental toxicants reach down through generations
2. Reproductive health providers should discuss environmental exposure risks with patients
3. Environmental factors in Tiny Tims near fatal illness
4. Increasing water scarcity in Californias Bay-Delta will necessitate trade-offs; hard decisions needed to balance various environmental risks
5. Stomata development in plants unraveled -- a valuable discovery for environmental research
6. Long-term research reveals causes and consequences of environmental change
7. New museum-university partnership ushers in new era of environmental science education
8. Tiny plants could cut costs, shrink environmental footprint
9. Wells Fargo fosters environmental conservation through University of Miamis RJD program
10. Environmental benefit of biofuels is overestimated, new study reveals
11. Reed Elsevier Environmental Challenge shortlists 2012 projects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
(Date:3/24/2015)... , March 24, 2015   Crossmatch ™, ... today announced that its U.are.U ® 4500 ... Goorin Bros . to achieve PCI compliance ... secures access to the POS terminal, protecting the ... of data breaches. With one-third ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 ... fraud case conviction losses. This figure accounts for a ... according to The Nilson Report, exceeds $11 billion globally. ... tool after a crime has occurred. Investor Mark ... polygraph expert Joe Paolella partnered to administer ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... Institute of Medicine (IOM) today announced the names of 70 ... meeting. Election to the IOM is considered one of ... and recognizes individuals who have demonstrated outstanding professional achievement and ... honor to welcome our highly distinguished colleagues to the Institute ...
... where more than 80% of the United States, strawberry ... impact of these vast production systems on groundwater contamination. ... issue of HortScience , changes in growers, cultural ... strawberry yields in the region by 140% during the ...
... Shenzhen, China, October 21, 2013 -- Life Technologies Corporation ... and service provider, jointly announced that BGI has purchased ... least a dozen more by the end of the ... industry. BGI also signed a supply and licensing agreement ...
Cached Biology News:Institute of Medicine Elects 70 New Members, 10 Foreign Associates 2Institute of Medicine Elects 70 New Members, 10 Foreign Associates 3Institute of Medicine Elects 70 New Members, 10 Foreign Associates 4Institute of Medicine Elects 70 New Members, 10 Foreign Associates 5Institute of Medicine Elects 70 New Members, 10 Foreign Associates 6Institute of Medicine Elects 70 New Members, 10 Foreign Associates 7Institute of Medicine Elects 70 New Members, 10 Foreign Associates 8Institute of Medicine Elects 70 New Members, 10 Foreign Associates 9New research informs California strawberry production practices 2BGI partners with Life Technologies to offer sequencing applications on ion torrent 2
(Date:5/4/2015)... May 4, 2015 GliaCure, a privately-held ... therapies for neurological and neuropsychiatric disorders based on ... of Alzheimer,s patients in a Phase 1b clinical ... compound developed as a potential disease-modifying treatment. GliaCure,s ... in that it both promotes the clearance of ...
(Date:5/4/2015)... May 4, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: ... an independent team of researchers from ... B4 (TB4) plays an important role in accelerating ... in an experimental mouse model, by promoting blood ... damaged dermal tissue.  The research found that the ...
(Date:5/4/2015)... PHILADELPHIA , May 4, 2015 ... help thousands of med students prepare for the United ... a world-leading provider of scientific, technical and medical information ... a free MOOC (Massive Open Online Course) designed to ... Licensing Examination (USMLE) Step 1, the first and most ...
(Date:5/1/2015)... May 1, 2015  Northwest Biotherapeutics (NASDAQ: NWBO ... personalized immune therapies for solid tumor cancers, announced today ... second tranche of a $40 million investment from Woodford ... first invested $25 million in NW Bio on November ... an agreement with the Company for a further $40 ...
Breaking Biology Technology:GliaCure Initiates Phase 1b Dosing in Alzheimer's Patients 2Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 2Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 3Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3
... Standard Networks, Inc., a Madison software developer, ... three months of 2006, thanks largely to a 125 ... and message transfer management products. , ,Citing its privately ... for MOVEit, but said Standard Network's overall revenues increased ...
... After a brief hiatus, Steven A. Schmidt ... and chief operating officer, effective April 26. , ,Schmidt, ... January to pursue another opportunity. He had served as ... and operations, and now will succeed founder Terrance D. ...
... Milwaukee, Wis. Hidden factors may contribute as ... projects as the easily identifiable suspects, technology executives were ... Clerestory Consulting in Chicago, delivered that sobering message ... Executives Club seminar on IT governance and project management. ...
Cached Biology Technology:Consultant says beware hidden costs of bad IT projects 2Consultant says beware hidden costs of bad IT projects 3
... controller is the successor to the original DS-U1. ... of the cameras in the Nikon DS camera ... interface. The DS-U2 transmits information at high speed, ... both hub and mass storage USB 2.0 interfaces. ...
...
... supplied as a 5x solution. Designed ... membrane-bound proteins without destroying antigenic binding ... radioisotopic signals from blots. Not recommended ... as a 5X solution sufficient to ...
... is for fine-tuning the bombardment conditions for ... recommended when you are first using the ... 0.25 g each of 0.6 micrometer, 1.0 ... 100 each of 9 rupture disks, 500 ...
Biology Products: