Navigation Links
Environmental enrichment important factor impacting cell transplantation and brain repair
Date:3/27/2013

Putnam Valley, NY. (March. 27, 2013) A team of Korean researchers investigated whether "environmental enrichment" can improve the neurobehavioral function of six week-old mice after transplantation of adipose-derived stem cells (ASCs) to treat hypoxic-ischemic brain injury, and found that brain repair (neurogenesis) was aided in some animals through exercise-induced fibroblast growth factor 2 (FGF2), a strong pro-angiogenic factor.

The post-transplantation environmental enrichment (EE) included use of a running wheel and exposure to "novel objects."

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0633seo.

"FGF2 was synergistically enhanced in the striata of mice treated with EE after ASC transplantation," said study co-author Dr. Sung-Rae Cho of the Yonsei University College of Medicine in Seoul, Korea. "The underlying mechanisms of this synergism included an enhanced repair process, such as higher engraftment of the transplanted ASCs, increased endogenous neurogenesis, and astrocytic activation coupled with the increase in FGF2."

Astrocytes, star-shaped brain cells that are also the most abundant brain cell, perform many functions, including supporting the cells that form the bloodbrain barrier and providing nutrients for nervous system tissue. Multipotent ASCs have been used for promoting angiogenesis (blood vessel growth) and are also known to secrete potentially beneficial growth factors.

"Hypoxic-ischemic brain injury is a major cause of damage to the fetal and neonatal brain," said Dr. Cho. "The majority of affected children demonstrate neurodevelopment impairment. However, cell-based therapy has emerged as a potential treatment. In this study we applied EE in the chronic
'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Effects of environmental toxicants reach down through generations
2. Reproductive health providers should discuss environmental exposure risks with patients
3. Environmental factors in Tiny Tims near fatal illness
4. Increasing water scarcity in Californias Bay-Delta will necessitate trade-offs; hard decisions needed to balance various environmental risks
5. Stomata development in plants unraveled -- a valuable discovery for environmental research
6. Long-term research reveals causes and consequences of environmental change
7. New museum-university partnership ushers in new era of environmental science education
8. Tiny plants could cut costs, shrink environmental footprint
9. Wells Fargo fosters environmental conservation through University of Miamis RJD program
10. Environmental benefit of biofuels is overestimated, new study reveals
11. Reed Elsevier Environmental Challenge shortlists 2012 projects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)...  Automation is fundamentally transforming the travel experience ... international borders. Over the past decade, ePassports, biometric ... travelers to self process through border control via ... an increasing number of airports, seaports, and land ... to Maxine Most , Principal at Acuity ...
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ... Adding functional endpoints to toxicology studies has evolved ...
(Date:12/10/2014)... Dec. 08, 2014 Research and Markets ... of the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration ... as rural banking and upgradation of the driver,s ... in the market. Besides the aforementioned projects, biometrics ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... in Spanish . , Pioneering studies ... Robert A. Waterland are helping explain how the foods ... the time of conceptionor what,s known as periconceptional nutritionmay ... her children,s health. In an early study, Waterland ...
... lack of very long chain fatty acids in photoreceptor cells ... an incurable eye disease. But researchers at the University of ... new study that lack of these fatty acids does not ... robs sight from children with the disease must start anew. ...
... mean failure of both summer and winter rains, according to ... The finding contradicts the commonly held belief that a ... monsoon season, and vice versa. The new research ... 1539 to 2008, generally both winter and summer rains were ...
Cached Biology News:Epigenetics mechanism may help explain effects of mom's nutrition on her children's health 2Long-suspected cause of blindness from eye disease disproved 2Monsoon failure key to long droughts in Southwest 2Monsoon failure key to long droughts in Southwest 3
(Date:12/24/2014)... Island, New York (PRWEB) December 23, 2014 ... and the Long Island Affiliate of ITRA Global, the national ... slow but steady recovery. This is evidenced by the ... the strong stock market. Low energy costs have held ... The only negative is the housing market remaining soft. ...
(Date:12/24/2014)... China Biologic Products, Inc. (NASDAQ: CBPO, ... integrated plasma-based biopharmaceutical company in China ... Shandong Taibang Biological Products Co. Ltd., has received ... Food and Drug Administration (the "CFDA") for its ... in the Company,s public filings, the CFDA inspected ...
(Date:12/24/2014)... YORK , Dec. 23, 2014  NeuroLifeSciences announced ... mazindol in children with attention deficit/hyperactivity disorder published in ... . The paper, titled "Pilot Phase ... disorder" ( Konofal et al, Drug Des ... ) shows that mazindol might be an effective, ...
(Date:12/22/2014)... 22, 2014 GenomeDx Biosciences today announced that ... Classifier, a genomic test for prostate cancer, was able ... managed by radical prostatectomy without adjuvant therapy. Although rapid ... uncommon, using tumor genomics to identify these men who ... an important advance. The study has been published ...
Breaking Biology Technology:ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3
... to see is based on molecules in the eye ... to visible light. Now, a new technique for ... molecules to be switched between two different configurations in ... Because the configuration changes are reversible and can be ...
... Bion Environmental,Technologies, Inc. (OTC Bulletin Board: BNET) today ... environmental,treatment technology compared to anaerobic digesters., Anaerobic ... produce energy,from livestock waste since the late 1800s. ... is still based on a biological process that,produces ...
... Premier healthcare,alliance Purchasing Partners division recently announced ... one of 15 winners,chosen for the Pinnacle ... suppliers,representing the top two percent of healthcare ... exceeds the expectations of,Premier and its members ...
Cached Biology Technology:Tethered molecules act as light-driven reversible nanoswitches 2Bion Outlines Differences between its Patented Comprehensive Livestock Environmental Treatment Technology and Anaerobic Digesters 2Bion Outlines Differences between its Patented Comprehensive Livestock Environmental Treatment Technology and Anaerobic Digesters 3Bion Outlines Differences between its Patented Comprehensive Livestock Environmental Treatment Technology and Anaerobic Digesters 4Bion Outlines Differences between its Patented Comprehensive Livestock Environmental Treatment Technology and Anaerobic Digesters 5Bion Outlines Differences between its Patented Comprehensive Livestock Environmental Treatment Technology and Anaerobic Digesters 6Bion Outlines Differences between its Patented Comprehensive Livestock Environmental Treatment Technology and Anaerobic Digesters 7Premier Healthcare Alliance Honors Siemens Healthcare Diagnostics for Excellence in Supplier Performance 2Premier Healthcare Alliance Honors Siemens Healthcare Diagnostics for Excellence in Supplier Performance 3
Ideal for chemical processing that requires downward flow of exhaust fumes. Powderful 1200 CFM blower draws fumes into sub-surface bonded charcoal filter for safe removal of organic vapors (final HEP...
... preparative LC/MS, using mass numbers as a ... ideal for performing investigation and research of ... both analytical and preparative operation. Switching between ... the software. This support provides a quick ...
... Intracellular Localization Kit provides a straight forward ... of your design, in an efficient yet ... Subcellular localization and functional inhibition of target ... of the labeled siRNA into mammalian cells. ...
Selective media for Salmonella...
Biology Products: