Navigation Links
Environmental enrichment can reduce cocaine use, researchers find
Date:4/6/2008

WINSTON-SALEM, N.C. Simple environmental enrichment and increased social stress can both affect the level of individual drug use, according to new monkey research at Wake Forest University School of Medicine.

Previous research has shown that social rank whether animals are dominant or subordinate within their social groups can affect the amount of cocaine that monkeys will self-administer. Housed in groups of four, male cynomolgus monkeys will invariably stratify by social rank from the most dominant to the most subordinate.

Once exposed to cocaine and taught to self-administer the drug, the more subordinate animals are far more inclined to engage in the human equivalent of serious drug abuse than are the dominant animals. Research has shown differences in certain neurochemicals in the brains of the animals, both as predictors and results of the social ranking, and therefore as predictors of drug abuse.

But would additional environmental enrichment or increased stress have an effect on cocaine self-administration"

The answer is yes, according to a report today (April 6) by Wake Forest researcher Michael A. Nader, Ph.D., at Experimental Biology 2008 in San Diego. The presentation was part of the scientific program of the American Society for Pharmacology and Experimental Therapeutics (ASPET).

Nader and colleagues worked with a group of 24 cynomolgus macaques who were already categorized socially. For additional enrichment, the monkeys were placed in larger-than-normal cages for three days. For increased stress, they were placed next to another social group for 15 minutes, acting as an intruder to that group.

The monkeys were then given their usual choice of an intravenous cocaine mixture or food pellets.

The enrichment reduced the drug response of all the animals; however, the detrimental affect of the stress more drug intake, less food was more prominent in the subordinate monkeys.

This is very significant for at least two reasons, said Nader, professor of physiology and pharmacology and of radiology. First, it is a result that could be directly applied to the human situation. It suggests that a better environment could alleviate at least some of the risk that individuals will turn to drugs.

Secondly, we are talking about very rudimentary enrichment here just a slightly improved living condition. Imagine what the effect could be with higher quality but easily achievable enrichment, such as interesting activities.


'/>"/>

Contact: Mark Wright
mwright@wfubmc.edu
336-716-3382
Wake Forest University Baptist Medical Center
Source:Eurekalert

Related biology news :

1. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
2. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
3. UCR engineers to develop new tool to measure how environmental exposures affect health
4. TAU scientists probe deep questions aboard EcoOceans environmental research ship
5. Environmental setting of human migrations in the circum-Pacific Region
6. UC-Riverside partners with Chinese university to address Chinas environmental problems
7. Food and environmental sustainability focus of ASA-CSSA-SSSA Annual Meetings
8. Relationship between environmental stress and cancer elucidated
9. Environmental researchers propose radical human-centric map of the world
10. New journal Energy & Environmental Science to be launched by RSC Publishing
11. Environmental exodus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2016)... AVIV, Israel , April 14, 2016 ... Behavioral Authentication and Malware Detection, today announced the appointment ... already assumed the new role. Goldwerger,s leadership ... BioCatch, on the heels of the deployment of its ... addition, BioCatch,s behavioral biometric technology, which discerns unique cognitive ...
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... ... May 24, 2016 , ... Cell therapies for a range ... by research at Worcester Polytechnic Institute (WPI) that yielded a newly patented method ... , The novel method, developed by WPI faculty members Raymond Page, PhD, professor ...
(Date:5/23/2016)... ... ... blood donations in South Texas and across the nation is growing. , But according to ... are on the decline. In fact, donations across the country are at their lowest point ... the last four years alone. , There is no substitute for blood. , “We want ...
(Date:5/23/2016)... and LONDON , May 23, 2016 /PRNewswire/ ... See Frontage Boost Efficiency by 40% - Frontage Implement ... - Frontage Enforce Quality, Compliance and Traceability Within the Bioanalytical lab ... labs in the United States and ... to be deployed across its laboratory facilities. In addition to serving ...
(Date:5/20/2016)... ... May 20, 2016 , ... The leading Regenerative Veterinary Medicine Company, VetStem ... have treated over 100 of their own patients with the VetStem Cell Therapy. Each ... of care for their patients. , The veterinarians are Dr Ross Rich former ...
Breaking Biology Technology: