Navigation Links
Environmental chemical blocks cell function
Date:12/6/2012

Bisphenol A, a substance found in many synthetic products, is considered to be harmful, particularly, for fetuses and babies. Researchers from the University of Bonn have now shown in experiments on cells from human and mouse tissue that this environmental chemical blocks calcium channels in cell membranes. Similar effects are elicited by drugs used to treat high blood pressure and cardiac arrhythmia. The results are now presented in the journal "Molecular Pharmacology."

The industrial chemical bisphenol A (BPA) is worldwide extensively utilized for manufacturing polycarbonates and synthetic resins. "This substance has been shown to affect the hormonal system and may have negative effects on the function of enzymes and carrier proteins," reports Prof. Dr. Dieter Swandulla from the Institute of Physiology II at the University of Bonn. BPA is associated with heart disease, diabetes, obesity, cancer, and neurological dysfunction. "It seems that fetuses and newborns are particularly sensitive to BPA," adds the physiologist. Due to its unpredictable effects, the EU Commission banned the use of BPA in baby bottles in 2011 as a precaution.

Bisphenol A blocks multiple essential calcium channels

The team of researchers around Prof. Swandulla now reports that BPA reversibly blocks calcium channels essential for cell function in mouse and human cells. Calcium ions flowing through these pore-like so-called channel proteins into living cells, control e.g. the contraction of heart muscle cells, the activity of enzymes, and the communication of nerve cells with each other. "Drugs such as those used to treat high blood pressure and cardiac arrhythmia on the one hand, and neurotoxins, such as heavy metals, on the other hand act on exactly the same calcium channels," explains the physiologist from the University of Bonn. "This indicates that BPA can indeed have adverse effects on human health." Since BPA binds to the calcium channels reversibly, there is at least the possibility of the chemical being eliminated from the body.

Bisphenol A and its derivatives are ubiquitous

Nowadays BPA and its related substances can be detected almost everywhere in the environment. Effective doses are found in CD's, paper money, thermal paper, food cans, dental fillings and flame retardants, even in the breathing air and in house dust. Humans are meanwhile chronically exposed to these compounds. "This is why it would be desirable to completely stop the production of BPA," says Prof. Swandulla. "Due to the high-volume production and its widespread occurrence, it would, however, take a very long time to remove this chemical from the environment and the human organism." Consequently, alternatives to BPA should be utilized which are harmless to humans and other organisms.


'/>"/>
Contact: Prof. Dr. Dieter Swandulla
dieter.swandulla@ukb.uni-bonn.de
40-228-736-0100
University of Bonn
Source:Eurekalert

Related biology news :

1. Forest killer plant study explores rapid environmental change factors
2. Environmental activist David Suzuki is fifth recipient of CWRU’s Inamori Ethics Prize
3. Concern about plans to close unique Canadian environmental project
4. Study shows hope of greater global food output, less environmental impact of agriculture
5. 2012 Reed Elsevier Environmental Challenge winners announced
6. Environmental groups should pool efforts to reach the public
7. New DataONE portal streamlines access to environmental data
8. University of Tennessee professor wins worlds top prize for ecology, environmental science
9. Environmental concerns increasing infectious disease in amphibians, other animals
10. UC Santa Barbara researchers play key role in UN Environmental Assessment
11. Scientists warn Brazils environmental leadership at risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... -- The global wearable medical device market, in terms of value, ... 5.31 billion in 2016, at a CAGR of 18.0% during the ... ... medical devices, launch of a growing number of smartphone-based healthcare apps ... providers, and increasing focus on physical fitness. Furthermore, ...
(Date:12/15/2016)... ... has announced the addition of the "Global Military Biometrics Market 2016-2020" ... global military biometrics market to grow at a CAGR of 7.5% during ... on an in-depth market analysis with inputs from industry experts. The report ... The report also includes a discussion of the key vendors operating in ...
(Date:12/15/2016)... 14, 2016 "Increase in mobile transactions is ... mobile biometrics market is expected to grow from USD ... 2022, at a CAGR of 29.3% between 2016 and ... the growing demand for smart devices, government initiatives, and ... "Software component is expected to grow at a high ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ... January 24, 2017 , ... Men who have a ... had a positive association with increased prostate growth or benign prostatic hyperplasia, according ... Journal involved 571 Korean men who underwent urological examinations, including serum prostate ...
(Date:1/24/2017)... USA & Geneva, Switerland (PRWEB) , ... January ... ... to announce the first commercially available malaria Plasmodium falciparum culture panels with standard ... falciparum culture panels, which are available in a range of concentrations from six ...
(Date:1/24/2017)... LAVAL, QC , Jan. 24, 2017 /PRNewswire/ - ProMetic ... the "Corporation") announced today that its orally active lead ... Medicine ("PIM") designation by the UK Medicines and Healthcare ... Syndrome ("AS"). A PIM designation is ... promising candidate for the Early Access to Medicines Scheme ...
(Date:1/24/2017)... DC (PRWEB) , ... January 23, 2017 , ... ... and food security, is the first-ever recipient of the National Academy of Sciences ... to global food security and nutrition. , The annual National Academy of Sciences ...
Breaking Biology Technology: