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Environment and diet leave their prints on the heart
Date:11/28/2011

l group looks different and is recognised differently by proteins, altering how the gene is expressed i.e. turned on or off.

DNA methylation is a crucial part of normal development, allowing different cells to become different tissues despite having the same genes. As well as happening during development, DNA methylation continues throughout our lives in a response to environmental and dietary changes which can lead to disease.

As a result of the study, Foo likens DNA methylation to a fifth nucleotide: "We often think of DNA as being composed of four nucleotides. Now, we are beginning to think there is a fifth the methylated C."

Foo also alludes to what the future holds for the study: "...and more recent basic studies now show us that our genome has even got 6th, 7th and 8th nucleotides... in the form of further modifications of cytosines. These are hydroxy-methyl-Cytosine, formylCytosine and carboxylCytosine = hmC, fC and caC! These make up an amazing shift in the paradigm"

As in most studies, as one question is resolved, another series of mysteries form in its place. The study shows that we are still on the frontier of Epigenetics and only just beginning to understand the link between the life we lead and the body we have.


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Contact: Dave Fyvie
davefyvie@gmail.com
44-122-333-2300
University of Cambridge
Source:Eurekalert

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