Navigation Links
Environment and diet leave their prints on the heart
Date:11/28/2011

A University of Cambridge study, which set out to investigate DNA methylation in the human heart and the 'missing link' between our lifestyle and our health, has now mapped the link in detail across the entire human genome.

The new data collected greatly benefits a field that is still in its scientific infancy and is a significant leap ahead of where the researchers were, even 18 months ago.

Researcher Roger Foo explains: "By going wider and scanning the genome in greater detail this time - we now have a clear picture of the 'fingerprint' of the missing link, where and how epigenetics in heart failure may be changed and the parts of the genome where diet or environment or other external factors may affect outcomes."

The study originally began investigating the differences in DNA methylation found in the human heart. Researchers compared data from a small number of people with end-stage cardiomyopathy who were undergoing heart transplantation, and the healthy hearts of age-matched victims of road traffic accidents.

DNA methylation leaves indicators, or "marks", on the genome and there is evidence that these "marks" are strongly influenced by external factors such as the environment and diet. The researchers have found that this process is different in diseased and normal hearts. Linking all these things together suggest this may be the "missing link" between environmental factors and heart failure.

The findings deepen our understanding of the genetic changes that can lead to heart disease and how these can be influenced by our diet and our environment. The findings can potentially open new ways of identifying, managing and treating heart disease.

The DNA that makes up our genes is made up of four "bases" or nucleotides cytosine, guanine, adenine and thymie, often abbreviated to C, G, A and T. DNA methylation is the addition of a methyl group (CH3) to cytosine.

When added to cytosine, the methy
'/>"/>

Contact: Dave Fyvie
davefyvie@gmail.com
44-122-333-2300
University of Cambridge
Source:Eurekalert

Page: 1 2

Related biology news :

1. Lack of large-scale experiments slows progress of environmental restoration
2. NIHs Genes, Environment and Health Initiative adds 6 studies
3. MU scientists go green with gold, distribute environmentally friendly nanoparticles
4. Growing a garden of future environmental leaders
5. Alternative to burning: environmentally sound disposal for wood chips
6. Childrens gardening programs grow environmental stewards
7. New center will focus environmental debate and produce solutions for action
8. 6 environmental research studies reveal critical health risks from plastic
9. Experts agree: Environmental standards needed for biofuels
10. Experts agree: to protect the environment, biofuel standards are needed
11. Hypertension disparity linked to environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2014)... director of the Physical Biosciences Division of Lawrence Berkeley ... recognized as a leading authority on the evolutionary design ... to systems and synthetic biology, has been named one ... Award by U.S. Energy Secretary Ernest Moniz. The E.O. ...
(Date:4/16/2014)... Geologic and soil processes are to blame for significant ... a study published recently in the Journal of Environmental ... all corners of Ohio showed that every single sample had ... the U.S. Environmental Protection Agency. The findings should not alarm ...
(Date:4/15/2014)... neurobiologists have found that genetically modified neural stem cells show ... the symptoms and pathology of Alzheimer,s disease. The pre-clinical trial ... Therapy , and the approach has been shown to work ... of the most common forms of dementia, is associated with ...
Breaking Biology News(10 mins):Berkeley Lab's Adam Arkin wins 2013 Lawrence Award 2Berkeley Lab's Adam Arkin wins 2013 Lawrence Award 3Significant baseline levels of arsenic found in Ohio soils are due to natural processes 2Significant baseline levels of arsenic found in Ohio soils are due to natural processes 3Significant baseline levels of arsenic found in Ohio soils are due to natural processes 4UCI study finds modified stem cells offer potential pathway to treat Alzheimer's disease 2
... London is part of an international consortium of scientists who ... euros, over ten years, to simulate ,everything we know about ... Science, Health and Medicine at King,s is a partner in ... dozens of groups of neuroscientists from many countries in Europe, ...
... service that is designed to make it quick and ... philanthropically-funded and not-for-profit, this project builds on the belief ... the coming era of Web-native science. , ImpactStory is ... data and radical transparency for the future of science. ...
... are caused by bacteria resistant to antibiotics and ... it is becoming increasingly difficult to treat infected patients ... which was published today, the Academy of Sciences and ... Sciences Leopoldina list eight recommendations that show ways to ...
Cached Biology News:Human Brain Project funded - 1 billion euros to map the human brain 2ImpactStory metrics of academic research outreach piloted by Pensoft Publishers 2
(Date:1/15/2014)... 15, 2014 DTS Language Services, Inc ... Web Portal for Life Science organizations who need document translations. ... subject matter of their documents in advance with a selection ... time-to-delivery of translations, often a critical factor in clinical and ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that ... leading Russian pharmaceutical company, to develop and commercialize nemonoxacin ... , Turkey and other ... novel antibiotic for the treatment of bacterial infections including ...
(Date:1/14/2014)... Jan. 14, 2014  3D Communications, a leading provider of strategic communications ... and media events in the United States ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as ...
(Date:1/14/2014)... and BETHESDA, Md. , Jan. 14, ... with two institutes from the National Institutes of Health ... bringing safer, more effective treatments to patients on a ... for Advancing Translational Sciences (NCATS) and the National Eye ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... June 11 The Champalimaud Foundation, one of ... J. Anthony Movshon , Director of New York ... T. Newsome , Investigator at The Howard Hughes Medical Institute ... the recipients of its 2010 Vision Award.  The prestigious Champalimaud ...
... June 5 Delcath Systems, Inc. (Nasdaq: ... device company focused on oncology, highlighted the Phase III ... the American Society of Clinical Oncology,s 2010 Annual Meeting, ... alternative care for patients with hepatic metastases from ocular or ...
... ... of the influenza virus and its human host, post-graduate student Stephen Huff of the University ... software downloads - best of all, the service is free. , ... (PRWEB) June 5, 2010 -- We call them computer ...
Cached Biology Technology:Prestigious International Champalimaud Vision Award to US Scientists 2Prestigious International Champalimaud Vision Award to US Scientists 3Prestigious International Champalimaud Vision Award to US Scientists 4Delcath Highlights Phase III Trial Results Presented at ASCO 2Delcath Highlights Phase III Trial Results Presented at ASCO 3Computational Microbiologist Uses His Expertise with Deadly Viruses to Devise a Superior System for Delivery of Safe, Free Software Downloads 2Computational Microbiologist Uses His Expertise with Deadly Viruses to Devise a Superior System for Delivery of Safe, Free Software Downloads 3Computational Microbiologist Uses His Expertise with Deadly Viruses to Devise a Superior System for Delivery of Safe, Free Software Downloads 4
... been designed for recovery of DNA from TAE and ... Ultra fast protocol: DNA is ready to use ... to resuspend Bead uniformity prevents shearing of high ... PCR) DNA is eluted into sterile water or ...
... enables efficient extraction of DNA fragments from 150 bp ... The procedure uses GelMelt solution to dissolve the gel ... silica membrane in a spin column format. After a ... buffer. Each spin column can bind up to 20 ...
... of DNA from agarose gels The SpinPrep Gel ... 150 bp to > 12,000 bp in size from ... the gel slice, followed by adsorption of the DNA ... After a wash step, the purified DNA is eluted ...
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human HLA-DR TAC is designed to deplete human HLA-DR from samples to isolate resting CD4+ or CD8+ T cells....
Biology Products: