Navigation Links
Entry point for hepatitis C infection identified
Date:1/24/2012

ailable and perfectly targeted to the receptor, Sainz said, so the researchers had an ideal method for testing NPC1L1's involvement in HCV infection.

They used the drug to block the receptor before, during and after inoculation with the virus, in cell culture and in a small-animal model, to evaluate the receptor's role in infection and the drug's potential as an anti-hepatitis agent.

The researchers showed that ezetimibe inhibited HCV infection in cell culture and in mice transplanted with human liver cells. And, unlike any currently available drugs, ezetimibe was able to inhibit infection by all six types of HCV.

The study, Uprichard said, opens up a number of possibilities for therapeutics.

Hepatitis C is the leading cause for liver transplantation in the U.S., but infected patients have problems after transplant because the virus attacks the new liver, Uprichard said.

While current drugs are highly toxic and often cannot be tolerated by transplant patients taking immunosuppressant drugs, ezetimibe is quite safe and has been used long-term without harm by people to control their cholesterol, Uprichard said. Because it prevents entry of the virus into cells, ezetimibe may help protect the new liver from infection.

For patients with chronic hepatitis C, ezetimibe may be able to be used in combination with current drugs.

"We forsee future HCV therapy as a drug-cocktail approach, like that used against AIDS," Uprichard said. "Based on cell culture and mouse model data, we expect ezetimibe, an entry inhibitor, may have tremendous synergy with current anti-HCV drugs resulting in an improvement in the effectiveness of treatment."


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. SIB launches next generation ExPASy, an entry portal to indispensable bioinformatics resources
2. Entry inhibitors show promise as drugs with new MOA for treatment of HBV and HDV infection
3. No-entry zones for AIDS virus
4. Tiny worm points to big promise
5. Rune Appoints John Haggard to Its Board of Advisors
6. Paleoclimate record points toward potential rapid climate changes
7. Growth through innovations and open access: The journal ZooKeys on point for digital taxonomy
8. Caltech scientists point to link between missing synapse protein and abnormal behaviors
9. Scientific sleuths pinpoint the guilty coral killers
10. Human, artificial intelligence join forces to pinpoint fossil locations
11. Chromosomal breakpoints linked to canine cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... overfishing in the English Channel has resulted in the ... left fishermen ,scraping the barrel, for increasing amounts of ... haddock and many other species at the head of ... removed from the area completely., These are some of ... at Plymouth University, in association with international non-profit research ...
(Date:7/10/2014)... at NJIT,s business incubator, received a $1.4 million federal ... use to staunch bleeding during brain surgery. , Surgeons ... the natural bio-polymer solutions in the gel will cohere ... , The gel can shorten an intracranial surgery ... time for the patient,s skull to be open and ...
(Date:7/10/2014)... that Courtney Aldrich, Ph.D., will head the brand-new, ... editor-in-chief. With the first issue slated for publication ... a growing demand for a place to publish ... is to develop a journal focused on diseases ... that advances the field and lays the foundation ...
Breaking Biology News(10 mins):Overfishing in the English Channel leaves fisherman scraping the bottom of the barrel 2Overfishing in the English Channel leaves fisherman scraping the bottom of the barrel 3A start-up at NJIT develops bleeding-control gel for brain surgery 2ACS Infectious Diseases: Unique chemistry journal names editor 2
... from a puddle or a pond to a vast ocean, ... animals. These so-called sessile suspension feeders are critical to aquatic ... contaminants by consuming bacteria. A study published by Cell Press ... that by actively changing the angle of their bodies relative ...
... time, it was thought impossible to isolate a pearl,s ... this elusive goal. Scientists Joana Meyer, from the ETH ... McDonald, and Laurent Cartier of the Swiss Gemmological Institute ... the first time in extracting trace amounts of DNA ...
... Oct. 7, 2013 ValidSoft, a global supplier of ... and a wholly owned subsidiary of Elephant Talk Communications ... commerce technology with Spindle,s new "MeNetwork360" mobile commerce ecosystem, ... ) conference being held from October 6 to October ...
Cached Biology News:How tiny organisms make a big impact on clean water 2A bad break for fake pearls 2ValidSoft and Spindle to Demo New Mobile Commerce Ecosystem at Money2020 2ValidSoft and Spindle to Demo New Mobile Commerce Ecosystem at Money2020 3ValidSoft and Spindle to Demo New Mobile Commerce Ecosystem at Money2020 4ValidSoft and Spindle to Demo New Mobile Commerce Ecosystem at Money2020 5
(Date:7/10/2014)... Senior supply chain management executives from over ... challenges of “Reducing Cost, Lead Time, & Defects in ... Describing the partnership of the Bio Supply Management Alliance ... ( SCMI) of the University of San Diego ... Kroc Institute of Peace and Justice in San Diego, ...
(Date:7/10/2014)... , July 10, 2014  Kainos Capital, a firm ... today announced that it has acquired the Slim-Fast brand ... the business. Terms of the transaction were not disclosed. ... meal replacement business that markets ready-to-drink shakes, powders, bars ... America and in the United ...
(Date:7/10/2014)... July 10, 2014   Ceres, Inc . (Nasdaq: ... company, announced today financial results for the three months ... its business. Ceres reported that the company ... performance this growing season in Brazil, which concluded in ... company,s sorghum evaluation areas for part of the growing ...
(Date:7/10/2014)... microscopic polymer light resonators that expand in the ... Photonics Laboratory have developed new optical sensors with ... sensors are ideal for detecting trace gas concentrations ... nature, and immunity to electromagnetic interference. , Although ... the MIT team conceived an extremely sensitive, compact ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Kainos Capital Acquires Slim-Fast From Unilever 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Swell new sensors 2
... ILI ), announced today that it will host ... at 4:30 p.m. ET to review the Company,s,first quarter ... developments., To access the live call, dial 877-627-6555 ... on the Investors,section of the Company,s website, http://www.ilgenetics.com ...
... Pharmaceuticals, Inc.,(Nasdaq: AMLN ) will be presenting at ... 2008 at 10:00 a.m. PT in Las Vegas. Michael,York, ... providing a corporate overview., The live presentation and ... made available following the event. The webcast and,recording will ...
... to augment Quintiles Consulting offerings, RESEARCH ... Corp. today announced that it has signed ... decision-analytics and market research,consulting firm located in ... business., The acquisition of Eidetics will ...
Cached Biology Technology:Interleukin Genetics Announces Conference Call and Webcast to Discuss First Quarter 2008 Business Results 2Quintiles Signs Agreement to Acquire Eidetics 2
Homogenizing Solution, 18ml Proteinase K - [50ug/l] 75 l...
Rb anti-Occludin (C-term GST)...
anti-JNK2 Immunogen: Recombinant human JNK2 protein Accession Number: NM_002752 Quality Assurance: Routinely evaluated by immunoblot. Molecular Weight: 46 and/or 54 kDa Available ...
...
Biology Products: