Navigation Links
Entry inhibitors show promise as drugs with new MOA for treatment of HBV and HDV infection
Date:4/2/2011

Berlin, Germany, Saturday 02 April 2011: Promising new viral hepatitis data presented today at the International Liver CongressTM show that entry inhibitors --a new mechanism of action for drugs to treat viral hepatitis -- could provide the first new hepatitis B and hepatitis D treatments for many years.1,2

Most current approved therapies directly target viral replication (e.g. nucleotide/side analogues), and can lead to the development of viral resistance or viral rebound after the end of treatment. Entry inhibitors prevent the virus from entering the cell and forming a stable replication complex, limiting the issue of viral rebound and resistance development.

Professor Heiner Wedemeyer, EASL's Secretary General, commented: "The current treatments available for hepatitis B & D are limited. These novel drugs are the first promising treatments for many years. The shift in the mechanism of action of these drugs from inhibiting the virus's replication directly to inhibiting its entry into the cell, and thus its replication means they are less likely to produce viral resistance; a huge problem faced by many of today's clinicians."

One study1 showed that treatment of ex-vivo liver cells with synthetic anti-lipopolysaccharide peptides (SALPs) during and prior to HBV infection was highly effective and dose dependent in inhibiting infection reducing markers of HBV infection (e.g. HBV RNA, HBV antigens) in the concentration range of 4-5 g/mL by 90% and 0.5-2 g/mL by 50%.

The study also demonstrated that SALPs showed activity against other viral (e.g. HIV, herpes) and microbial (e.g. peritonitis, colitis and pneumonia) infections. Therefore, SALPs represent a very promising therapeutic strategy to treat viral hepatitis infection and concomitant bacterial infection which often leads to life threatening systematic complications.

Other studies2,3 illustrated the enormous value of the chimaeric mouse model of chronic HBV and
'/>"/>

Contact: Travis Taylor
easlpressoffice@cohnwolfe.com
44-784-306-9451
European Association for the Study of the Liver
Source:Eurekalert

Page: 1 2

Related biology news :

1. No-entry zones for AIDS virus
2. New growth inhibitors more effective in plants, less toxic to people
3. A powerful new technology to identify HIV inhibitors
4. KINAXO launches KinAffinity services for efficient profiling of kinase inhibitors in cells or tissue
5. Will loss of plant diversity compromise Earths life-support systems?
6. New test shows promise for accurate diagnosis of Turner syndrome
7. Stem cells show promise in repairing a childs heart
8. Scripps Research team creates new synthetic compound with HIV-fighting promise
9. RevaTen platelet-rich plasma shows promise as potential treatment for heart attacks
10. Co-management holds promise of sustainable fisheries worldwide
11. New method for making tiny catalysts holds promise for air quality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... allow us to better understand how the fish ... and provide the type of environmental data to ... siting of protected areas," said Paula Whitfield, a ... Ocean Science (NCCOS) and lead author of the ... the temperate-tropical transition zone, where historically, both temperate ...
(Date:9/15/2014)... the Department of Science and Technology in Society in ... Virginia Tech, has won a 2014 National Science Foundation ... and problems of creating a global nuclear emergency response ... Nuclear Power Plant in March 2011 was a turning ... Schmid said. Three of the plant,s six nuclear reactors ...
(Date:9/15/2014)... For multicellular lifeplants and animalsto thrive in the ... the water. In certain coastal areas, extreme oxygen-starvation ... destroy food web structure. As dissolved oxygen levels ... life into microbial community metabolism resulting in impacts ... , Over the past 50 years, oxygen minimum ...
Breaking Biology News(10 mins):Study finds warming Atlantic temperatures could increase range of invasive species 2'Nuclear disasters don't respect national boundaries' 2Decoding virus-host interactions in the oxygen-starved ocean 2Decoding virus-host interactions in the oxygen-starved ocean 3Decoding virus-host interactions in the oxygen-starved ocean 4Decoding virus-host interactions in the oxygen-starved ocean 5
... centuries, seafarers were plagued by wood-eating gribble that destroyed ... on wooden piers and docks in coastal communities. ... Sustainable Bioenergy Centre at the Universities of York and ... the apparently indigestible. , By examining genes that ...
... Spanish . , Geraniums may hold the key ... 300 plant species and costs the ornamental plant industry $450 ... Agricultural Research Service (ARS). The beetle, Popillia ... plants, including ornamentals, soybean, maize, fruits and vegetables. But within ...
... could substantially reduce the expense of costly treatments ... or bacterial cells by growing these human therapeutic ... have recently gained attention for their ability to ... study, published online this week in Plant Biotechnology ...
Cached Biology News:Seafarers' scourge provides hope for biofuel future 2Geraniums could help control devastating Japanese beetle 2Study shows potential for using algae to produce human therapeutic proteins 2Study shows potential for using algae to produce human therapeutic proteins 3Study shows potential for using algae to produce human therapeutic proteins 4
(Date:9/16/2014)... According to Jeff Howell, Partner of Nidea ... new development in Downtown Toronto is expanding at a ... 755 storeys of new development last week (including three ... dominating the Toronto skyline for the foreseeable future in ... for new development. , As the Toronto city council ...
(Date:9/15/2014)... phase transitionsthink solid, liquid, and gasbut much ... drops. If phase transitions occur at the ... subtle fluctuations can dramatically transform a material. ... of Energy,s Brookhaven National Laboratory and Stony ... of absolute zero to isolate and probe ...
(Date:9/15/2014)... 16, 2014 Cancer Immunotherapy ... Adoptive T-cell Therapies is a new market research ... the three principal types of therapeutics that have ... in cancer immunotherapy (which is often called "immuno-oncology") ... and Adoptive cellular immunotherapy. , The regular ...
(Date:9/15/2014)... Calif. , Sept. 15, 2014  FlexTech ... (RFP) for flexible, printed product demonstrators (demos) and ... two-stage RFP process with pre-proposals due on October ... 2015.  Funds for proposals ultimately selected are provided ... have a significant cost share by the proposing ...
Breaking Biology Technology:ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 3Elusive quantum transformations found near absolute zero 2Elusive quantum transformations found near absolute zero 3Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 2Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 3Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 4Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 5FlexTech Alliance Issues 2015 Request for Proposals in Flexible, Printed Electronics 2
... model, said Christopher Kuhl, CEO and founder of Kuhlfusion. ... business executive from facility and resources standpoints. , ... hub for the growing number of individuals and organizations ... Diverse members of the tech field ranging from freelance ...
... dont even exist at many of their residences, tribal ... to be wired by Motorola Canopy , the ... could be the most underserved communities in need of ... high-speed Internet access for its residents and students, tribal ...
... MADISON, Wis. - This Thursday, the 17th annual SBIR/STTR ... Technology Awards Banquet at the Crowne Plaza in Madison, ... of the Small Business Innovation Research (SBIR) and Small ... access the $1.5 billion federal dollars available to small ...
Cached Biology Technology:IT Fusion to Enhance Milwaukees Entrepreneurial IT Climate 2Motorola Canopy Wires Indian Reservations 2Annual Conference Honors Tech Grant Winners 2
...
... Varian 500-MS LC Ion Trap is ... LC/MS analysis where sensitivity, reliability and ... provides a robust platform for demanding ... resolution, and mass stability reflect the ...
... This modular benchtop fume hood ... allowing safe indoor release of ... most organic contaminants. Configurations are ... flow; options include final HEPA ...
... for biological safety labs (BSL) and ... Class 10/ISO 3) and easy sterilization. ... surfaces that are easy to wipe ... simplify cleaning. Unique double-wall panel design ...
Biology Products: