Navigation Links
Engineers create intelligent molecules that seek-and-destroy diseased cells
Date:2/13/2009

breast, prostate and brain cancers, including immunotherapy applications based on reprogramming human immune response to different diseases. The researchers work directly with clinicians at the City of Hope Cancer Center (a National Cancer Institute designated Comprehensive Cancer Center in Duarte, Calif.) that have ongoing immunotherapy trials for treating glioma, a severe type of brain cancer.

"Our goal is to make more effective therapies by taking advantage of the natural capabilities of our immune system and introducing slight modifications in cases where it is not doing what we would like it to do," Smolke said. She hopes to translate her technologies into intelligent cellular therapeutics for glioma patients in the next five years. "That's a very optimistic view," she said. "But so far things have been moving quickly."

The broader implications for using intelligent molecules in immunotherapy and gene therapy seem limitless. Researchers and doctors can use this approach by targeting a specific cellular function or behavior they want to control in a particular disease. Then they can identify signals indicative of viral infection, host immune response, or drugs the clinician is administering and engineer the molecules to change the cell function in response to those signals.

"In a lot of therapies, you have nonspecific side effects or you're balancing the desired effect of the therapy on diseased cells or infection with its undesired effects on the entire host," Smolke said. Current chemotherapy treatments for cancer, and even many gene therapies, have drastic and debilitating consequences for patients. The designer molecules provide a whole new targeting accuracy that should mitigate these side effects.

"This is all very front-end work," Smolke said. "We've just started to move these foundational technologies into these sorts of downstream medical applications, and so there is a lot to learn which makes it that much more exciting."
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Biomedical engineers detective work reveals antibiotic mechanism
2. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
3. UC San Diego bioengineers fill holes in science of cellular self-organization
4. Engineers create bone that blends into tendons
5. Kalyon wins Society of Plastics Engineers 2008 Research Award
6. Caltech engineers build mini drug-producing biofactories in yeast
7. UC Riverside bioengineer receives high honor from chemical engineers
8. Engineers create 3-D model to help biologists combat blue tongue virus
9. Scientists find that squid beak is both hard and soft, a material that engineers want to copy
10. Chemical engineers discover new way to control particle motion
11. Policing cells demand ID to tell friend from foe, say University of Pennsylvania cell engineers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... modeling study suggests that fish consumption advisories for ... to long-lived contaminants like persistent organic pollutants (POPs). ... of researchers including University of Toronto Scarborough PhD ... at how different levels of environmental contamination, a ... chemicals in the body influenced exposure in her ...
(Date:4/17/2014)... in German . ... they also provide us with a continuous stream of information ... or sit still in a car the world glides ... retinas. Seemingly without effort, our brain calculates self-motion from this ... and a steady gaze during our own movements. Together with ...
(Date:4/17/2014)... professor Rajendra Singh Thursday as a "Champion of ... solar deployment in the residential, commercial and industrial ... of Electrical and Computer Engineering and director of ... local hero leading the charge across the country ... power and driving policy changes at the local ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4White House honors Clemson professor as 'Champion of Change' for solar deployment 2
... applauds the US Court of Appeals for the District of ... against the use of public funds for embryonic stem cell ... cell research and the nation,s scientific community. Most importantly, ... suffering from incurable diseases," says Susan L. Solomon, CEO of ...
... a groundbreaking new videojournal to complement the ... & Advanced Surgical Techniques has been ... ( http://www.liebertpub.com ). Videoscopy ( http://www.liebertpub.com/products/product.aspx?pid=390 ) ... of the latest techniques and technologies used ...
... ground to plant trees may be an excellent gateway to ... University of Maryland study, based on work with New York ... in environmental stewardship, the more s/he engages with other types ... Together ", which the researchers released to coincide with Arbor ...
Cached Biology News:Groundbreaking minimally invasive surgical videojournal launched by Mary Ann Liebert Inc. 2Digging in dirt, Arbor Day planting, may help build citizenship: UMD study 2
(Date:1/15/2014)... The Pittcon Organizing Committee is pleased to ... Tech , an e-Journal and producer of Food ... second year for the co-location of Food Labs Conference to ... that the registration fee to attend the two-day Food Lab ...
(Date:1/15/2014)... 15, 2014 Look inside the new ... for the lab, from fluid handling to instruments to ... ship when you order. , Preferred Solutions features ... from the L/S® model for precise flow control and ...
(Date:1/15/2014)... and SAN JOSE, California , ... biotechnology company developing antibody-drug conjugates for cancer, today announced the ... of Directors. Dr Reynolds has over 20 years, development experience ... Officer at Seattle Genetics. "I am delighted to ...
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2
... Mylan Inc. (Nasdaq: MYL ) today ... company,s credit ratings, including the "Corporate Family Rating," to ... is stable.  According to Moody,s: "Mylan,s ... in the global generic pharmaceutical industry, its strong geographic ...
... a molecular diagnostics company, announced today the publication of ... which may influence the amount of fetal DNA found ... Kypros Nicolaides, MD, of Harris Birthright Research Centre for ... Kingdom. (Logo: http://photos.prnewswire.com/prnh/20120326/NY75864LOGO ) ...
... a metal surface at the scale of atoms and ... computer chips or the reflective silver in optical components ... may seem high-tech and precise, the technique has been ... physics. In a new study, Brown University engineers modeled ...
Cached Biology Technology:Moody's Upgrades Mylan 2Ariosa Diagnostics Announces Publication of Study on Influential Factors Affecting Fetal DNA Concentration in Blood of Pregnant Women 2How ion bombardment reshapes metal surfaces 2How ion bombardment reshapes metal surfaces 3
... Alsevers solution is an isotonic, balanced salt ... preservative, which permits the storage of whole blood ... usage, an equal volume of blood is collected ... but thoroughly, mixed. The solution is placed in ...
... OligoMix or individual RNA sequences from high throughput ... small RNAs from LC Sciences. These products provide ... millions) of DESIGNED sequences delivered in a microtube ... containing a single verified RNA sequence. This is ...
... GCMS-QP2010s Gas Chromatograph/Mass Spectrometer, utilizing many ... GCMS-QP2010 Plus, offers high throughput and ... excellent performance-to-cost ratio. Like the GCMS-QP2010 ... linear velocity for optimum separation, 20 ...
... Assay Kit contains all reagents necessary to ... lineage, as determined by staining for mineralization. ... necessary reagents and a protocol for quantifying ... product is useful for studying the effects ...
Biology Products: