Navigation Links
Engineers create intelligent molecules that seek-and-destroy diseased cells
Date:2/13/2009

Current treatments for diseases like cancer typically destroy nasty malignant cells, while also hammering the healthy ones. Using new advances in synthetic biology, researchers are designing molecules intelligent enough to recognize diseased cells, leaving the healthy cells alone.

"We basically design molecules that actually go into the cell and do an analysis of the cellular state before delivering the therapeutic punch," said Christina Smolke, assistant professor of bioengineering who joined Stanford University in January.

"When you look at a diseased cell (e.g. a cancer cell) and compare it to a normal cell, you can identify biomarkerschanges in the abundance of proteins or other biomolecule levelsin the diseased cell," Smolke said. Her research team has designed molecules that trigger cell death only in the presence of such markers. "A lot of the trick with developing effective therapeutics is the ability to target and localize the therapeutic effect, while minimizing nonspecific side effects," she said.

Smolke will present the latest applications of her lab's work at the American Association for the Advancement of Science (AAAS) meeting in Chicago on Friday, Feb. 13.

These designer molecules are created through RNA-based technologies that Smolke's lab developed at the California Institute of Technology. A recent example of these systems, developed with postdoctoral researcher Maung Nyan Win (who joined Smolke in her move to Stanford), was described in a paper published in the Oct. 17, 2008, issue of Science.

"We do our design on the computer and pick out sequences that are predicted to behave the way we like," Smolke said. When researchers generate these sequences inside the operating system of a cell, they reprogram the cell and change its function. "Building these molecules out of RNA gives us a very programmable and therefore powerful design substrate," she said.

Smolke's team focuses on well-researched model systems in
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Biomedical engineers detective work reveals antibiotic mechanism
2. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
3. UC San Diego bioengineers fill holes in science of cellular self-organization
4. Engineers create bone that blends into tendons
5. Kalyon wins Society of Plastics Engineers 2008 Research Award
6. Caltech engineers build mini drug-producing biofactories in yeast
7. UC Riverside bioengineer receives high honor from chemical engineers
8. Engineers create 3-D model to help biologists combat blue tongue virus
9. Scientists find that squid beak is both hard and soft, a material that engineers want to copy
10. Chemical engineers discover new way to control particle motion
11. Policing cells demand ID to tell friend from foe, say University of Pennsylvania cell engineers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... of asthma, allergies and other chronic inflammatory disorders among ... part to their reduced exposure to the microbes that ... paper. , The article, published in the journal ... in urban centers who have less access to green ... a condition caused by immune system dysfunction. , When ...
(Date:4/23/2014)... their mid-thirties and forties, face a devastating prognosis: ... decades. "Mutant" protein clusters, long blamed for the ... primary focus of therapies in development by pharmaceutical ... Gerardo Lederkremer and Dr. Julia Leitman of Tel ... in collaboration with Prof. Ulrich Hartl of the ...
(Date:4/23/2014)... People who have had a stroke, often suffer motor ... a study conducted in Taiwan, that will be published ... but is currently freely available on-line as an unedited ... when one group of stroke victims had their own ... brain and a similar group did not, those who ...
Breaking Biology News(10 mins):Rural microbes could boost city dwellers' health 2Rural microbes could boost city dwellers' health 3On the defensive 2On the defensive 3Autologous stem cell therapy improves motor function in chronic stroke victims 2
... Jobs, livelihoods and ecotourism industries can benefit from having ... coral reefs, marine researchers say. Despite their small ... often get more attention, herbivorous fish play a vital ... support the livelihoods of 500 million people worldwide, say ...
... 8th May 2012. A group of researchers from the ... INAD (Hospital del Mar Neuropsychiatry and Addictions Institute) has ... general overview at a chemical, pharmacological and behavioural level ... the Recreational Drugs European Network, as a new abused ...
... It is increasingly recognized that chronic psychotropic drug ... Indeed, clinical studies in humans present an intriguing picture: ... may contribute to cortical gray matter loss in patients, ... and mania, may preserve gray matter in patients. ...
Cached Biology News:Weed-eating fish 'help protect jobs, livelihoods' 2Weed-eating fish 'help protect jobs, livelihoods' 3Internet and new drugs: A challenge for public health 2Psychiatric medication effects on brain structure 2
(Date:1/14/2014)... AUSTIN, Texas , Jan. 14, 2014 ... analyze and research medicinal plants and therapeutic derivatives ... industry, health professionals, and researchers about the challenges ... (Logo: http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The ...
(Date:1/14/2014)... In recent years, growing suspicion about the pharmaceutical ... and promotion has led to unprecedented levels of public ... about the insidious impact of commercialization of research, has ... the world’s biggest pharmas for illegal marketing activities, allegations ...
(Date:1/14/2014)... 2014   Kinaxis ®, provider of RapidResponse ®, a ... operations planning ( S&OP ) service, is proud to be ... will be held at the Hilton San Diego Bayfront, January ... Elisabeth Kaszas , Director of Supply Chain at Amgen, ...
(Date:1/14/2014)... NY (PRWEB) January 14, 2014 During the ... now known as “The Doctor’s Plague.” In this time period, ... hands. This led, at times, to the death of vulnerable ... today don’t know that they may be unwittingly transmitting herpes ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... Attention To ,The Sneak Thief of Sight, NEW ... one of the,main causes of blindness around the globe, ... have announced the first annual,World Glaucoma Day, to be ... marked,by awareness and educational events organized by glaucoma institutions ...
... Inc.,(Nasdaq: HOLX ) today announced that Patrick Sullivan, ... presenting at the Merrill,Lynch Global Pharmaceutical, Biotechnology and Medical ... Hyatt Hotel in New York, NY., Interested parties ... of,Hologic,s investor presentation on Tuesday, February 5, 2008 at ...
... AlphaVax has,assembled its Cytomegalovirus (CMV) Advisory Board to provide ... candidates through clinical,development. To be chaired by Dr. Robert ... -- Mark Schleiss, MD, Professor, Associate Head ... Legion Chair in the Department of Pediatrics and Director, ...
Cached Biology Technology:World Glaucoma Day Set for March 6th 2Hologic to Present at Merrill Lynch Global Pharmaceutical, Biotechnology and Medical Device Conference 2AlphaVax Announces New CMV Advisory Board 2
Enables rapid purification of double-stranded DNA fragments = 200 bp, including, for example, PCR reaction products, DNA fragments obtained in restriction enzyme digests, or double-stranded cDNA...
5 minutes from gel band to purified DNA...
... commonly used in baculovirus plaque ... agaroses either contain contaminants that ... or lack the physical characteristics ... Novagen's BacPlaque Agarose is pre-qualified ...
...
Biology Products: