Navigation Links
Engineers create bone that blends into tendons
Date:8/29/2008

Engineers at Georgia Tech have used skin cells to create artificial bones that mimic the ability of natural bone to blend into other tissues such as tendons or ligaments. The artificial bones display a gradual change from bone to softer tissue rather than the sudden shift of previously developed artificial tissue, providing better integration with the body and allowing them to handle weight more successfully. The research appears in the August 26, 2008, edition of the Proceedings of the National Academy of Sciences.

"One of the biggest challenges in regenerative medicine is to have a graded continuous interface, because anatomically that's how the majority of tissues appear and there are studies that strongly suggest that the graded interface provides better integration and load transfer," said Andres Garcia, professor in the George W. Woodruff School of Mechanical Engineering at the Georgia Institute of Technology.

Garcia and former graduate student Jennifer Phillips, along with research technician Kellie Burns and their collaborators Joseph Le Doux and Robert Guldberg, were not only able to create artificial bone that melds into softer tissues, but were also able to implant the technology in vivo for several weeks.

They created the tissue by coating a three-dimensional polymer scaffold with a gene delivery vehicle that encodes a transcription factor known as Runx2. They generated a high concentration of Runx2 at one end of the scaffold and decreased that amount until they ended up with no transcription factor on the other end, resulting in a precisely controlled spatial gradient of Runx2. After that, they seeded skin fibroblasts uniformly onto the scaffold. The skin cells on the parts of the scaffold containing a high concentration of Runx2 turned into bone, while the skin cells on the scaffold end with no Runx2 turned into soft tissue. The result is an artificial bone that gradually turns into soft tissue, such as tendons or ligaments.

If the technology is able to pass further testing, one application could be anterior cruciate ligament (ACL) surgery. Oftentimes, ACL surgery fails at the point where the ligament meets the bone. But if an artificial bone/ligament construct with these types of graded transitions were implanted, it might lead to more successful outcomes for patients.

"Every organ in our body is made up of complex, heterogeneous structures, so the ability to engineer tissues that more closely mimic these natural architectures is a critical challenge for the next wave of tissue engineering," said Phillips, who is now working at Emory University as a postdoctoral research fellow in developmental biology.

Now that they have been able to demonstrate that they can implant the tissue in vivo for several weeks, the team's next step is to show that the tissue can handle weight for an even longer period of time.


'/>"/>

Contact: David Terraso
david.terraso@comm.gatech.edu
404-385-2966
Georgia Institute of Technology
Source:Eurekalert  

Related biology news :

1. Kalyon wins Society of Plastics Engineers 2008 Research Award
2. Caltech engineers build mini drug-producing biofactories in yeast
3. UC Riverside bioengineer receives high honor from chemical engineers
4. Engineers create 3-D model to help biologists combat blue tongue virus
5. Scientists find that squid beak is both hard and soft, a material that engineers want to copy
6. Chemical engineers discover new way to control particle motion
7. Policing cells demand ID to tell friend from foe, say University of Pennsylvania cell engineers
8. Engineers demonstrate a new type of optical tweezer
9. Where will we find the next generation of engineers?
10. Birds, bats and insects hold secrets for aerospace engineers
11. Elephant engineers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Engineers create bone that blends into tendons
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... its 2016 Annual Report on Form 10-K on Thursday April 13, ... ... the Investor Relations section of the Company,s website at http://www.nxt-id.com ... http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... 16, 2017 , ... While art and science are often thought of as ... might think. A Mesh Is Also a Snare, a group exhibition presented by ... Esther Klein Gallery (EKG) on August 17 and run through September 30. An opening ...
(Date:8/15/2017)... After spending the past two years building a state-of-the-art ... GeneFo now offers this platform to healthcare stakeholders (hospitals, foundations, biopharma ... and data collection vis a vis their members, under their own ... of this offer. ... ...
(Date:8/15/2017)... ... August 15, 2017 , ... ... of 6” modular downlights designed to stay tightly sealed and perform efficiently for ... damp and wet location listings just aren't enough, such as: hospitals; behavioral health ...
(Date:8/14/2017)... ... 2017 , ... Opal Kelly, a leading producer of powerful ... the release of SYZYGY™, a new open standard for connecting high-performance peripherals to ... low cost, low pin-count, high-performance connectivity solution between FPGAs and single-purpose hardware peripherals. ...
Breaking Biology Technology: