Navigation Links
Engineers create bone that blends into tendons
Date:8/29/2008

Engineers at Georgia Tech have used skin cells to create artificial bones that mimic the ability of natural bone to blend into other tissues such as tendons or ligaments. The artificial bones display a gradual change from bone to softer tissue rather than the sudden shift of previously developed artificial tissue, providing better integration with the body and allowing them to handle weight more successfully. The research appears in the August 26, 2008, edition of the Proceedings of the National Academy of Sciences.

"One of the biggest challenges in regenerative medicine is to have a graded continuous interface, because anatomically that's how the majority of tissues appear and there are studies that strongly suggest that the graded interface provides better integration and load transfer," said Andres Garcia, professor in the George W. Woodruff School of Mechanical Engineering at the Georgia Institute of Technology.

Garcia and former graduate student Jennifer Phillips, along with research technician Kellie Burns and their collaborators Joseph Le Doux and Robert Guldberg, were not only able to create artificial bone that melds into softer tissues, but were also able to implant the technology in vivo for several weeks.

They created the tissue by coating a three-dimensional polymer scaffold with a gene delivery vehicle that encodes a transcription factor known as Runx2. They generated a high concentration of Runx2 at one end of the scaffold and decreased that amount until they ended up with no transcription factor on the other end, resulting in a precisely controlled spatial gradient of Runx2. After that, they seeded skin fibroblasts uniformly onto the scaffold. The skin cells on the parts of the scaffold containing a high concentration of Runx2 turned into bone, while the skin cells on the scaffold end with no Runx2 turned into soft tissue. The result is an artificial bone that gradually turns into soft tissue, such as tendo
'/>"/>

Contact: David Terraso
david.terraso@comm.gatech.edu
404-385-2966
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Kalyon wins Society of Plastics Engineers 2008 Research Award
2. Caltech engineers build mini drug-producing biofactories in yeast
3. UC Riverside bioengineer receives high honor from chemical engineers
4. Engineers create 3-D model to help biologists combat blue tongue virus
5. Scientists find that squid beak is both hard and soft, a material that engineers want to copy
6. Chemical engineers discover new way to control particle motion
7. Policing cells demand ID to tell friend from foe, say University of Pennsylvania cell engineers
8. Engineers demonstrate a new type of optical tweezer
9. Where will we find the next generation of engineers?
10. Birds, bats and insects hold secrets for aerospace engineers
11. Elephant engineers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Engineers create bone that blends into tendons
(Date:6/18/2013)... UT Arlington environmental engineer has been awarded a ... to ensure water quality and flow in the ... , Andrew Kruzic, UT Arlington associate professor of ... locations to add monochloramine to the water in ... new pump stations and pipelines. Adding monochloramine is ...
(Date:6/18/2013)... are expecting a very large "dead zone" in the ... level in the Chesapeake Bay this year, based on ... University of Michigan, Louisiana State University, and the ... Gulf of Mexico hypoxic "dead" zone will be between ... among the ten largest recorded. That would range from ...
(Date:6/18/2013)... Health has awarded $12.7 million to match nine ... industry compounds to explore new treatments for patients ... muscular dystrophy and schizophrenia. The collaborative pilot initiative, ... is led by the National Center for Advancing ... Common Fund. , The process of developing a ...
Breaking Biology News(10 mins):UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline 2NOAA, partners predict possible record-setting deadzone for Gulf of Mexico 2NOAA, partners predict possible record-setting deadzone for Gulf of Mexico 3NOAA, partners predict possible record-setting deadzone for Gulf of Mexico 4NIH to fund collaborations with industry to identify new uses for existing compounds 2NIH to fund collaborations with industry to identify new uses for existing compounds 3NIH to fund collaborations with industry to identify new uses for existing compounds 4
... School of Medicine researchers have identified the precursors of cells ... of defense against invading pathogens. The study will appear on ... a future issue. , A tight network of cells covering ... group of cells known as Langerhans cells. These cells ingest ...
... researchers at Duke's Pratt School of Engineering have imaged ... demonstration showed that the probes could give surgeons a ... are performed through tiny "keyhole" incisions. , If the ... lead to more precise and safer endoscopic surgeries, said ...
... sensor for detecting cocaine –?made with inexpensive, off-the-shelf electronics ... the University of California, Santa Barbara. Two local high ... discovery. The potential applications of the sensor are far-reaching ... The high school students made their own sensors and ...
Cached Biology News:Source of crucial immune cell in the skin discovered 23D ultrasound device poised to advance minimally invasive surgery 23D ultrasound device poised to advance minimally invasive surgery 3Portable cocaine sensor developed at UC Santa Barbara 2Portable cocaine sensor developed at UC Santa Barbara 3
(Date:6/19/2013)... MO BIO Laboratories, Inc., the leader ... nucleic acid purification, announces the launch of the ... pure protein from all soil types. This expansion ... th anniversary of the company and showcases ... http://photos.prnewswire.com/prnh/20130619/LA32633 ) The NoviPure™ ...
(Date:6/19/2013)... Today DuPont Executive Vice President James C. ... the greatest challenge facing our time – ensuring food ... spoke at the International Food and Agribusiness Management ... for students to contribute their time and talents to ... in collaboration with others. , “Food is one of ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 India’s ... business can potentially be worth up to a ... opportunity, the Indian government is taking serious action ... the process. , This presentation will examine:, ... regulations ,     Immediate and long term impacts ...
(Date:6/19/2013)... 19, 2013 Adding to their already ... stocked with Simport’s Dropette® and Heathrow Scientific disposable ... customer doing basic biology, chemistry and any type of ... For over 35 years, Simport has been supplying the ... products like the Simport Dropette®. Simport’s Dropette® is a ...
Breaking Biology Technology:MO BIO Laboratories, Inc. launches the first kit for protein extraction from soil 2DuPont Leader Calls for New Generation of Food Visionaries to Fight Hunger 2Leading Pipette Distributor Pipette.com Now Stocks Transfer Pipettes: Simport’s Dropette and Heathrow Scientific Disposable Plastic Transfer Pipettes 2
... ... Orthopedics in Sheffield Village, Ohio, just west of Cleveland, now offers reverse total shoulder ... an intact rotator cuff. Until now, these individuals -- who are not candidates for ... pain." , ...
... ... Phillips, Media Investment Bankers, has announced that James R. Brennan, FACHE, ... and COO/CSO at MediServe Information Systems, Jim currently runs a business ... technology license and partnership deals, notably the sale of VanSlyck to ...
... , IRVINE, Calif., Aug. 31 Masimo ... CO-Oximetry(TM) and Measure-Through Motion and Low-Perfusion pulse oximetry, today announced ... Weisel Partners Healthcare Conference 2009 at the Four Seasons Hotel ... a.m. EDT. A live audiocast of the presentation will ...
Cached Biology Technology:Robert Zanotti, MD, Is First Lorain County, Ohio Orthopedic Surgeon to Perform Reverse Total Shoulder Replacement 2Robert Zanotti, MD, Is First Lorain County, Ohio Orthopedic Surgeon to Perform Reverse Total Shoulder Replacement 3Robert Zanotti, MD, Is First Lorain County, Ohio Orthopedic Surgeon to Perform Reverse Total Shoulder Replacement 4DeSilva + Phillips, Mediabankers, names Jim Brennan to Head Healthcare IT M&A Practice 2DeSilva + Phillips, Mediabankers, names Jim Brennan to Head Healthcare IT M&A Practice 3Masimo to Present at the Thomas Weisel Partners Healthcare Conference 2009 2
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
...
... preactivated with carbonyl diimidazole chemistry that covalently ... PS10 array contains the same binding chemistry ... an updated hydrophobic barrier coating. These arrays ... diameter spots spatially compatible with one column ...
...
Biology Products: