Navigation Links
Engineering cartilage replacements
Date:12/2/2011

A lab discovery is a step toward implantable replacement cartilage, holding promise for knees, shoulders, ears and noses damaged by osteoarthritis, sports injuries and accidents.

Self-assembling sheets of mesenchymal stem cells permeated with tiny beads filled with growth factor formed thicker, stiffer cartilage than previous tissue engineering methods, researchers at Case Western Reserve University have found. A description of the research is published in the Journal of Controlled Release.

"We think that the capacity to drive cartilage formation using the patient's own stem cells and the potential to use this approach without lengthy culture time prior to implantation makes this technology attractive," said Eben Alsberg, associate professor in the departments of Biomedical Engineering and Orthopaedic Surgery, and senior author of the paper.

Alsberg teamed with biomedical engineering graduate students Loran D. Solorio and Phuong N. Dang, undergraduate student Chirag D. Dhami, and Eran L. Vieregge, a student at Case Western Reserve School of Medicine.

The team put transforming growth factor beta-1 in biodegradable gelatin microspheres distributed throughout the sheet of stem cells rather than soak the sheet in growth factor.

The process showed a host of advantages, Alsberg said.

The microspheres provide structure, similar to scaffolds, creating space between cells that is maintained after the beads degrade. The spacing results in better water retention a key to resiliency.

The gelatin beads degrade at a controllable rate due to exposure to chemicals released by the cells. As the beads degrade, growth factor is released to cells at the interior and exterior of the sheet, providing more uniform cell differentiation into neocartilage.

The rate of microsphere degradation and, therefore, cell differentiation, can be tailored by the degree to which the microsphere are cross-linked. With
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bioengineering yields new approaches for diagnosing and treating traumatic brain injury
2. Arizona Engineering associate professor earns national recognition
3. GeneArt® Algae Engineering Kits by Life Technologies™
4. Creation of the largest human-designed protein boosts protein engineering efforts
5. Manufacturing microscale medical devices for faster tissue engineering
6. UM College of Engineering receives $1 million grant from the Department of Energy
7. Testing geoengineering
8. VTT and the MSI combine their unique competencies to a new Center for Bioengineering
9. Survey finds public support for geoengineering research
10. NIH training grant awarded to Boston University School of Medicine and College of Engineering
11. Engineering team heads to Antarctica to explore hidden lake
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... DETROIT , Jan. 13, 2015 Technology Showcase, Hall ... iris-based identity authentication solutions, today announced it will showcase its ... and developed by the Department of Energy,s Oak Ridge ... International Auto Show . EyeLock,s iris identity authentication technology is ...
(Date:1/22/2015)... 2015  Analyst Report Issued by Small Cap IR. In 2011, ... planet-wide, transactions at merchants on the leading payment cards rose ... credit, debit, and prepaid cards reached 6.54 billion.  Eight million ... card usage in 2012, and credit and debit card fraud ...
(Date:12/24/2014)... in December 2014, the 1U™ app has helped ... remember their usernames and passwords through replacing the antiquated system ... people who have struggled to remember usernames and passwords, ... on redefining identity, announced today that it is offering the ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3
... Providing clues into why the severity of a common ... new Johns Hopkins study shows that each one of three ... off a unique reaction in the nerve cells it invades. ... 25 percent of people worldwide, can trigger or exacerbate psychotic ...
... will play a key role in helping to conserve the ... conservation and research station located in the Manu Biosphere Reserve ... station for the San Diego Zoo and marks a significant ... is located in the western Amazon and is recognized by ...
... research may be relevant to the effects of ... development of obesity in her children. An ... suggests that a high-fat, high-carbohydrate diet causes oxidative ... the offspring to obesity and diabetes. Feeding rats ...
Cached Biology News:Toxoplasmosis: The strain explains severity of infection 2San Diego Zoo Global joins effort to conserve the Amazonian rain forest through Peru field station 2Antioxidants in pregnancy prevent obesity in animal offspring 2
(Date:1/23/2015)... January 23, 2015 Biofertilizers stimulate microbial ... as nitrogen and phosphorous through the activities in the ... is increasing due to the stress on reducing environmental ... , The report defines and segments the bio fertilizers ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Shimadzu ... new UV-1280 multipurpose UV-visible spectrophotometer. Offering wavelength scanning ... instrument is ideal for applications in a variety ... science. , The user-friendly UV-1280 enables intuitive operation, ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart ... 2014 was a record-breaking year across the board for the ... Smart Data Platform and our Smart Data solutions, our customers ... data which led to record growth for the company in ...
(Date:1/22/2015)... Pipette.com has added the Eppendorf ... portfolio of Eppendorf products. , The Eppendorf Centrifuge 5424/5424 ... 5424/5424 R and receive the following:, , ... or Eppendorf Reference 2 ,     3 Free ...
Breaking Biology Technology:Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 2Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 3Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 4Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2Cambridge Semantics Announces Record Results for 2014 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2
... WILMINGTON, Del., Feb. 29 AstraZeneca (NYSE:,AZN) today ... Application,(sNDA) to the U.S. Food and Drug Administration ... Tablets to seek,approval for the treatment of major ... therapy in adult patients., MDD affects 15 ...
... Feb. 29 Syngenta,announced today that the 2007 ... the US Securities and Exchange Commission., The ... http://www.syngenta.com ,in the Investor Relations section; hard ... shareholders free of charge upon request., Syngenta ...
... German . , Automation makes a business ... of small and medium-sized enterprises (SMEs). However, for many ... inflexible, too big or too expensive. SMErobot now promises ... technology in small and medium-sized businesses: this EU project ...
Cached Biology Technology:AstraZeneca Submits sNDA for SEROQUEL XR(TM) for the Treatment of Major Depressive Disorder 2AstraZeneca Submits sNDA for SEROQUEL XR(TM) for the Treatment of Major Depressive Disorder 3AstraZeneca Submits sNDA for SEROQUEL XR(TM) for the Treatment of Major Depressive Disorder 4AstraZeneca Submits sNDA for SEROQUEL XR(TM) for the Treatment of Major Depressive Disorder 5AstraZeneca Submits sNDA for SEROQUEL XR(TM) for the Treatment of Major Depressive Disorder 6AstraZeneca Submits sNDA for SEROQUEL XR(TM) for the Treatment of Major Depressive Disorder 7AstraZeneca Submits sNDA for SEROQUEL XR(TM) for the Treatment of Major Depressive Disorder 8Filing of 2007 Annual Report on Form 20-F 2SMErobot: A new generation of robots for small and medium-sized enterprises at Automatica 2008 2SMErobot: A new generation of robots for small and medium-sized enterprises at Automatica 2008 3SMErobot: A new generation of robots for small and medium-sized enterprises at Automatica 2008 4
Request Info...
Estrogen Receptor (ER) Competitor Assay Kits Green for Estrogen Receptors-alpha and -beta (ER-Alpha and ER-Beta) are ideal for screening novel estrogen receptor binding compounds and endocrine disrup...
Collected from 8-12 week old sexually mature rats. Pricing: $100/unit for 1 - 10 units...
Mouse Aminopeptidase P2/XPNPEP2 Affinity Purified PAb Protein Family: Aminopeptidases, Metalloproteases...
Biology Products: