Navigation Links
Engineering cartilage replacements
Date:12/2/2011

A lab discovery is a step toward implantable replacement cartilage, holding promise for knees, shoulders, ears and noses damaged by osteoarthritis, sports injuries and accidents.

Self-assembling sheets of mesenchymal stem cells permeated with tiny beads filled with growth factor formed thicker, stiffer cartilage than previous tissue engineering methods, researchers at Case Western Reserve University have found. A description of the research is published in the Journal of Controlled Release.

"We think that the capacity to drive cartilage formation using the patient's own stem cells and the potential to use this approach without lengthy culture time prior to implantation makes this technology attractive," said Eben Alsberg, associate professor in the departments of Biomedical Engineering and Orthopaedic Surgery, and senior author of the paper.

Alsberg teamed with biomedical engineering graduate students Loran D. Solorio and Phuong N. Dang, undergraduate student Chirag D. Dhami, and Eran L. Vieregge, a student at Case Western Reserve School of Medicine.

The team put transforming growth factor beta-1 in biodegradable gelatin microspheres distributed throughout the sheet of stem cells rather than soak the sheet in growth factor.

The process showed a host of advantages, Alsberg said.

The microspheres provide structure, similar to scaffolds, creating space between cells that is maintained after the beads degrade. The spacing results in better water retention a key to resiliency.

The gelatin beads degrade at a controllable rate due to exposure to chemicals released by the cells. As the beads degrade, growth factor is released to cells at the interior and exterior of the sheet, providing more uniform cell differentiation into neocartilage.

The rate of microsphere degradation and, therefore, cell differentiation, can be tailored by the degree to which the microsphere are cross-linked. With
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bioengineering yields new approaches for diagnosing and treating traumatic brain injury
2. Arizona Engineering associate professor earns national recognition
3. GeneArt® Algae Engineering Kits by Life Technologies™
4. Creation of the largest human-designed protein boosts protein engineering efforts
5. Manufacturing microscale medical devices for faster tissue engineering
6. UM College of Engineering receives $1 million grant from the Department of Energy
7. Testing geoengineering
8. VTT and the MSI combine their unique competencies to a new Center for Bioengineering
9. Survey finds public support for geoengineering research
10. NIH training grant awarded to Boston University School of Medicine and College of Engineering
11. Engineering team heads to Antarctica to explore hidden lake
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... 2015 About hand geometry biometrics Security ... organizations, telecommunication and hospitals as well as for individuals ... numeric keypads are used to prevent unauthorised access. Hand ... fingers of an individual, width of the fingers, and ... light and reflectors can be used for capturing the ...
(Date:9/2/2015)... 2015 Security of data and assets ... government organizations, telecommunications, hospitals, as well as individuals. ... being used to prevent unauthorised access. Technological advancements ... individuals could gain access to secure premises after ... hardware devices and numeric codes. However, hackers also ...
(Date:9/2/2015)... Biometric technology ... system which uses identical human characteristic such as ... and finger print. Increasing number of terror attacks ... which provides high level of security. Traditional security ... are vulnerable to attacks. Furthermore, Biometric technology uses ...
Breaking Biology News(10 mins):Global Hand Geometry Biometrics Market 2015-2019 2Global Hand Geometry Biometrics Market 2015-2019 3Global Biometrics Spending Market in the Government Sector 2015-2019 2Global Biometrics Spending Market in the Government Sector 2015-2019 3Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 2Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 3Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 4
... on the growth and yield of horticultural crops; studies ... the world,s irrigated land unsuitable for crop production. Imbalances ... mineral deficiencies, and drastic physiological and biochemical changes in ... their water usageto conserve water, some plants close their ...
... researchers report that the brains of tiny spiders are so ... their legs. As part of ongoing research to understand how ... nervous systems of nine species of spiders, from rainforest giants ... the spiders get smaller, their brains get proportionally bigger, filling ...
... 2011)Regular exercise has proven benefits in preventing and ... tough to meet the American Diabetes Association guidelines of ... A new study, conducted by researchers at McMaster University, ... a small proof-of-principle study in eight type 2 diabetes ...
Cached Biology News:Salt-tolerant crops show higher capacity for carbon fixation 2A whole new meaning for thinking on your feet 2Exercising harder -- and shorter -- can help Type 2 diabetes 2Exercising harder -- and shorter -- can help Type 2 diabetes 3
(Date:9/4/2015)... Research and Markets ( ... "Biopreservation Market by Product, Biospecimen, Application and ... report to their offering. The global ... Million by 2020 from USD 2,150.48 Million in ... 2015 and 2020. Biopreservation ensures the ...
(Date:9/4/2015)... ... September 04, 2015 , ... ... the BioBot 1, at the 2015 TERMIS World Congress in Boston. The launch ... biomedical engineering institutions around the world. The printer is revolutionary for its compact ...
(Date:9/4/2015)... (PRWEB) , ... September 04, 2015 , ... ... of product safety and pharmacovigilance services and software tools to pharmaceutical and life ... Mobile by Allergan Japan. PRIMO Mobile is a mobile data intake solution that ...
(Date:9/3/2015)... ... ... The latest addition to the Mettler-Toledo PCE portfolio is the newly ... pharmaceutical and healthcare industry can use the LSS to print track-and-trace labels for their ... can be fully integrated into the production line and is also available as a ...
Breaking Biology Technology:Global Biopreservation Market 2015-2020 - Product, Biospecimen, Application and End User Analysis of the $3.73 Billion Industry 2Global Biopreservation Market 2015-2020 - Product, Biospecimen, Application and End User Analysis of the $3.73 Billion Industry 3BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 2BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 3BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 4November Research Group’s PRIMO Mobile Goes Live at Allergan Japan 2Print and Verify Labels On The Production Line With New Label Serialization Stations 2Print and Verify Labels On The Production Line With New Label Serialization Stations 3
... , NEW YORK, Dec. 4 Stemline Therapeutics, Inc. today ... SL-401 and SL-501, in both in vitro and animal ... poster presentation at the upcoming 51st Annual Meeting of the American ... December 5-8, 2009. The poster will be presented by Stemline,s collaborators ...
... 3 VIA Pharmaceuticals, Inc. (Nasdaq: VIAP ), a ... treatment of cardiovascular and metabolic disease, today announced that it ... FDG-PET clinical trial of VIA-2291. , The FDG-PET trial ... in the US and Canada including Massachusetts General Hospital, Mount ...
... , NEW DELHI, ... Officer at Shenzhen Beike Biotechnology Co. Ltd.,( http://www.beikebiotech.com ), spoke ... November 22, 2009. Beike is China,s leading,stem cell research and regenerative ... the Indian Podiatry Association (IPA), aimed,to help podiatrists and researchers with ...
Cached Biology Technology:Stemline Therapeutics Announces Poster Presenting in vivo and Anti-Cancer Stem Cell Activity of SL-401 against Chronic Myeloid Leukemia (CML) at the 51st Annual Meeting of the American Society of Hematology (ASH) 2VIA Pharmaceuticals Completes Patient Visits in Phase 2 Trial of VIA-2291 2VIA Pharmaceuticals Completes Patient Visits in Phase 2 Trial of VIA-2291 3VIA Pharmaceuticals Completes Patient Visits in Phase 2 Trial of VIA-2291 4Beike Biotechnology CSO Speaks on Role of Stem Cells in Treating Diabetic Foot Disease at IPA Diabetic Foot Care Conference, India 2Beike Biotechnology CSO Speaks on Role of Stem Cells in Treating Diabetic Foot Disease at IPA Diabetic Foot Care Conference, India 3
...
RNase-Free DNase 50 l...
... polymerase is a DNA-dependent RNA polymerase which ... It efficiently synthesizes in vitro transcripts ... stream from a T7 promoter. Transcripts ... for in vitro translation, substrates in RNA ...
... Klenow fragment is a ... coli DNA Polymerase I ... -> 5 exonuclease activity, but ... activity. Klenow retains the polymerization ...
Biology Products: