Navigation Links
Engineered stem cell advance points toward treatment for ALS
Date:5/28/2013

MADISON, Wis. Transplantation of human stem cells in an experiment conducted at the University of Wisconsin-Madison improved survival and muscle function in rats used to model ALS, a nerve disease that destroys nerve control of muscles, causing death by respiratory failure.

ALS (amyotrophic lateral sclerosis) is sometimes called "Lou Gehrig's disease." According to the ALS Association, the condition strikes about 5,600 Americans each year. Only about half of patients are alive three years after diagnosis.

In work recently completed at the UW School of Veterinary Medicine, Masatoshi Suzuki, an assistant professor of comparative biosciences, and his colleagues used adult stem cells from human bone marrow and genetically engineered the cells to produce compounds called growth factors that can support damaged nerve cells.

The researchers then implanted the cells directly into the muscles of rats that were genetically modified to have symptoms and nerve damage resembling ALS.

In people, the motor neurons that trigger contraction of leg muscles are up to three feet long. These nerve cells are often the first to suffer damage in ALS, but it's unclear where the deterioration begins. Many scientists have focused on the closer end of the neuron, at the spinal cord, but Suzuki observes that the distant end, where the nerve touches and activates the muscle, is often damaged early in the disease.

The connection between the neuron and the muscle, called the neuro-muscular junction, is where Suzuki focuses his attention. "This is one of our primary differences," Suzuki says. "We know that the neuro-muscular junction is a site of early deterioration, and we suspected that it might be the villain in causing the nerve cell to die. It might not be an innocent victim of damage that starts elsewhere."

Previously, Suzuki found that injecting glial cell line-derived neurotropic factor (GDNF) at the junction helped the neurons
'/>"/>

Contact: Masatoshi Suzuki
msuzuki@vetmed.wisc.edu
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Engineered microbes grow in the dark
2. Europe needs genetically engineered crops, scientists say
3. Recruiting engineered cells to work for warfighters
4. Market Analysis: Biomaterials and Engineered Protein
5. Painting with catalysts: Nano-engineered materials for detoxifying water by use of sunlight
6. Engineered bacteria make fuel from sunlight
7. Production of 5-aminovaleric and glutaric acid by metabolically engineered microorganism
8. Engineered immune cells produce complete response in child with an aggressive pediatric leukemia
9. Leukemia patients remain in remission more than 2 years after engineered T cell therapy
10. Bioengineered marine algae expands environments where biofuels can be produced
11. Soft Robotics: A groundbreaking new journal on engineered soft devices that Interact with Living Systems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... and number of connections in transcription factor networks (TFNs) ... a study published in PLOS Computational Biology ... signature contributes to a network,s resilience against mutations. ... assortativity of TFN models has a greater effect on ... of assortativity," said Dov A. Pechenick, PhD, lead author ...
(Date:8/29/2014)... stretch them, twist them, fold them: modern materials that ... potential, whether as artificial skin or electronic paper. , ... a challenge but a new way of working with ... a game-changer. , Previous success in the field ... use of precious gold and silver nanowires. , ...
(Date:8/28/2014)... marine protected areas is needed to protect fish species ... from the Wildlife Conservation Society and other organizations, previous ... largest numbers of species, often at the expense of ... , Many vital ecological functions of ocean ... food for millions of people. This study uncovers ...
Breaking Biology News(10 mins):Assortativity signatures of transcription factor networks contribute to robustness 2Copper shines as flexible conductor 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... The U.S. Department of Agriculture,s National Institute of Food ... million grant to study integrated management of zoosporic pathogens ... green industry. Chuanxue Hong, professor of plant pathology, ... and Life Sciences and the project,s director, explained that ...
... -- A new study by Rice University bioengineers finds that ... like prima donnas. The protein, called kinesin, is a two-legged ... pulling power of kinesin both singly and in pairs, and ... kinesins don,t work well together -- in part because they ...
... -- Members of the American Society of Plant Biologists ... their genes, efforts that in addition to furthering our ... to enhance agricultural productivity, grow nutritious foods, and diminish ... are leading the majority of the 28 new research ...
Cached Biology News:$2.7 million research award to aid nursery, floriculture industry 2'Prima donna' protein doesn't work well in pairs 2'Prima donna' protein doesn't work well in pairs 3ASPB members lead new plant genome research program awards 2ASPB members lead new plant genome research program awards 3ASPB members lead new plant genome research program awards 4ASPB members lead new plant genome research program awards 5ASPB members lead new plant genome research program awards 6ASPB members lead new plant genome research program awards 7ASPB members lead new plant genome research program awards 8ASPB members lead new plant genome research program awards 9ASPB members lead new plant genome research program awards 10ASPB members lead new plant genome research program awards 11
(Date:8/29/2014)... (PRWEB) August 29, 2014 Three ... Energy's 2014 Hydrogen Production R&D Award ... by splitting water using sunlight. , Shared with ... and the University of Nevada, Las Vegas (UNLV), ... developing models of photoelectrochemical solar-hydrogen production and corrosion ...
(Date:8/29/2014)... 2014 A major challenge before new ... dense realm of Boston-Cambridge, is gaining visibility that can ... Sherley, the Director of Boston’s Adult Stem Cell Technology ... national visibility of his company an important priority since ... addition to a social media marketing campaign ...
(Date:8/28/2014)... DIEGO, California, USA (PRWEB) August 28, 2014 ... the Department of Physics and Optical Science and Director ... the University of North Carolina at Charlotte, and co-founder ... been elected to serve as the 2015 Vice President ... , SPIE 2014 President Philip Stahl announced recent election ...
(Date:8/28/2014)... Ca. (PRWEB) August 28, 2014 Best ... rating for an alcohol-based hand sanitizer, asks food processors ... by comparing the hand sanitizer they’re currently using to ... . Hand hygiene is critical to fighting cross-contamination and ... Best Sanitizers believes there are key criteria that ...
Breaking Biology Technology:Livermore Team Awarded for Hydrogen Production Research 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3
... Dan Ross to Lead Business Development Team , , ... that provides pricing and reimbursement services to pharmaceutical and biotechnology companies, ... open its new San Diego office. , , ... both investment banking and strategic consulting capacities. His primary role ...
... INCLINE VILLAGE, Nev., Sept. 8 PDL BioPharma, Inc. ... for the third quarter ended September 30, 2009 of approximately ... quarter of 2008. Royalty revenues are based on second quarter ... Synagis(R), which is marketed by MedImmune. When compared with 2008, ...
... Sept. 8 /PRNewswire-Asia/ -- Sinovac Biotech Ltd.,(NYSE Amex: ... announced,that the first lot of PANFLU.1, its H1N1 vaccine, has ... Control of Pharmaceutical and,Biological Products and obtained the Certificate for ... ready for delivery. , The released ...
Cached Biology Technology:PriceSpective Continues Global Expansion With New San Diego Office 2PDL BioPharma Provides Third Quarter 2009 Revenue Guidance of Approximately $71 Million 2PDL BioPharma Provides Third Quarter 2009 Revenue Guidance of Approximately $71 Million 3Sinovac Obtains Lot Release Certificate for Its First Batch of H1N1 Vaccine 2
... Wellpro 384, compatible ... automated liquid handling system ... quickly and accurately prepares ... dilutions. The Wellpro ...
... a new generation bulk reagent dispenser offering ... for pharmaceutical and biotech laboratories. Based on ... Multidrop Combi has been designed for effortless ... l and multiple plate types including 1536. ...
384 well block MBSr. Robot compatible block ejection mechanism. Stackable. (384 well block - holds 384 well plate)...
... 45° Fixed Angle Rotor ... Centra CL2, Centra CL3CL3R, and ... concentration of sputum samples and ... samples. Provides individual aerosol containment. ...
Biology Products: