Navigation Links
Engineered pig stem cells bridge the mouse-human gap
Date:6/4/2009

The discovery that adult skin cells can be 'reprogrammed' to behave like stem cells has been a major scientific boon, providing a way to tap the potential of embryonic stem cells without the associated ethical quandaries. Now, in a study appearing online in JBC, researchers have created a line of such reprogrammed stem cells from adult pigs. As pigs are large animals with a physiology very similar to humans, this work provides a valuable model to study the therapeutic potential of this new "induced pluripotent stem cell" (iPS) technology.

iPS cells have already been developed from both mice and humans. Both systems will help researchers answer many biological and genetic questions about these cells, but still leave a gap before clinical applications can begin. These iPS cells cannot be tested on humans before thorough safety and efficacy trials in animal models, but the size, physiology and short lifespan of mice makes them less than ideal for these trials.

Duanqing Pei and colleagues turned to a better pre-clinical model: pigs. These large animals share a remarkably similar biology to humans, as evidenced by their already extensive contributions to medicine, such as using pig insulin to treat diabetes or pig heart valves in transplant surgery. The research group modified the current iPS protocols to successfully generate a line of stem cells from a miniature Tibetan pig (whose smaller size would make breeding and maintenance easier). A biochemical analysis revealed these cells expressed the key proteins that would classify them as 'stem cells' and had the ability to differentiate into many other types of cells.

Importantly, these pig iPS cells more closely resembled human stem cells than other animals, confirming their value in pre-clinical studies. The researchers believe porcine iPS technology is an emerging and exciting field that should progress quickly and lead to many applications.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
2. MIT works toward engineered blood vessels
3. Engineered weathering process could mitigate global warming
4. Genetically engineered corn may harm stream ecosystems
5. Study shows genetically engineered corn could affect aquatic ecosystems
6. Engineered eggshells to help make hydrogen fuel
7. Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
8. A step toward tissue-engineered heart structures for children
9. Genetically corrected blood cells obtained from skin cells from Fanconi anemia patients
10. Scientists explain how death receptors designed to kill our cells may make them stronger
11. Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
(Date:3/27/2017)... ROCKVILLE CENTRE, N.Y. , March 27, 2017 ... by Healthcare Information and Management Systems Society (HIMSS) ... Analytics Outpatient EMR Adoption Model sm . In ... top 12% of U.S. hospitals using an electronic ... recognized CHS for its high level of EMR ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... , ... September 20, 2017 ... ... a leading global provider of engineering, architecture, project controls, construction management, commissioning ... cleanrooms, today announced the unveiling of the iCON™ brand which represents the ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... ... organization focused on molecular manufacturing and other transformative technologies, announced the winners for ... Experiment and the other for Theory in nanotechnology/molecular manufacturing. , Established in 1993 ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... of funded early-stage tech companies. “Grit” author Angela Duckworth and her team at ... ic@3401 community is Cooley, an international law firm with decades of experience supporting ...
(Date:9/19/2017)... 19, 2017 ValGenesis Inc., the global leader ... to announce the strategic partnership with VTI Life Sciences ... validation services using the latest technology available in the ... clients with efficient and cost-effective validation services using ValGenesis ... the ValGenesis VLMS system. ...
Breaking Biology Technology: