Navigation Links
Engineered liver may shed light on effects of chemicals in the environment
Date:6/6/2011

The liver is the primary organ in the human body that metabolizes foreign compounds such as drugs, alcohol, cigarette smoke, and environmental chemicals. Using the liver as an alarm system, researchers are starting to better understand the different levels of toxicity from these compounds and their effects on the human body.

One of these researchers is Padma Rajagopalan, director of the Virginia Tech Institute of Critical Technology and Applied Science's Center for Systems Biology of Engineered Tissues. She is a past recipient of a National Science Foundation CAREER Award to fund her work on cell migration, and in the past two years she has received more than $1 million in funding to create and study engineered tissues that mimic the human liver.

Now, the U.S. Environmental Protection Agency has awarded one its three-year $750,000 Science to Achieve Results award that it calls STAR to Rajagopalan of chemical engineering and core faculty in the School of Biomedical Engineering and Sciences. T.M. Murali of Virginia Tech's Department of Computer Science is a co-principal investigator on this award and is also co-director of the systems biology center. Marion Ehrich of the Virginia-Maryland Regional College of Veterinary Medicine and co-director of its Laboratory for Neurotoxicity Studies will serve as a consultant on the project.

The newly funded work will take advantage of Rajagopalan's in vitro three-dimensional liver mimic, an engineered functional tissue. Since the liver plays a central role in the detoxification of the human body, the new project will establish this liver mimic as an effective model for studying the effects of different types of toxicants on the liver.

Rajagopalan said, "With the increasing number of chemicals, such as pesticides, being used in agriculture and industry today, humans are exposed to these substances to much greater extents. However, we lack a comprehensive understanding of the cell-and organ-wide effects of mixtures of toxic substances and how interactions among them can lead to chronic health problems. These gaps in our knowledge pose fundamental barriers to preventing or mitigating life-threatening toxicant-induced health issues."

This award will specifically look at chemically-driven liver damage resulting from exposure to carbon tetrachloride, found in cleaning agents among other products, and to dichloroethylene, used as a solvent in floor finishes such as waxes and lacquers, among other purposes.

With Murali's expertise in computer science and bioinformatics , they will be able to establish a combined experimental and computational pipeline for toxicity testing and risk assessment based on three-dimensional liver mimics and biological process linkage networks.


'/>"/>

Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

Related biology news :

1. Intelligent design: Engineered protein fragment blocks the AIDS virus from entering cells
2. Purdue team creates engineered organ model for breast cancer research
3. Can engineered bugs help generate biofuels? Study holds promise
4. Engineered plants make potential precursor to raw material for plastics
5. Most complete beer proteome finding could lead to engineered brews
6. Engineered coral pigment helps scientists to observe protein movement
7. Native-like spider silk produced in metabolically engineered bacterium
8. Genetically engineered crops benefit many farmers, but the technology needs proper management to remain effective
9. Genetically engineered tobacco plant cleans up environmental toxin
10. Engineered tobacco plants have more potential as a biofuel
11. Bioengineered materials promote the growth of functional vasculature, new study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Engineered liver may shed light on effects of chemicals in the environment
(Date:3/17/2016)... , March 17, 2016 ABI Research, ... forecasts the global biometrics market will reach more ... 118% increase from 2015. Consumer electronics, particularly smartphones, ... fingerprint sensors anticipated to reach two billion shipments ... Dimitrios Pavlakis , Research Analyst at ABI ...
(Date:3/15/2016)... , March 15, 2016 Yissum Research ... the technology-transfer company of the Hebrew University, announced today ... remote sensing technology of various human biological indicators. Neteera ... $2.0 million from private investors. ... on the detection of electromagnetic emissions from sweat ducts, ...
(Date:3/14/2016)... March 14, 2016 http://www.apimages.com ... --> - Renvoi : image disponible via ... --> --> DERMALOG, le ... de nouveaux lecteurs d,empreintes digitales pour l,enregistrement des ... sera utilisé pour produire des cartes d,identité aux ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... (PRWEB) , ... May 23, 2016 , ... ... building management solutions and services based in Aurora, Ohio, has broken ground on ... business in the Research Triangle Park area, this new location solidifies a commitment ...
(Date:5/22/2016)... ... 2016 , ... Doctors in Rome say micronutrients found in certain foods have ... Mesothelioma has just posted an article on the new research. Click here to ... Sciences and Translational Medicine evaluated more than 150 studies on polyphenols in cancer for ...
(Date:5/20/2016)... ... May 20, 2016 , ... Kablooe Design, a leading provider of product ... official 25th anniversary of the business. “We have worked hard to build long-term relationships,” ... for the privilege and honor of serving their product design and development needs through ...
(Date:5/20/2016)... , ... May 20, 2016 , ... The recent recall ... as reported by Food Safety News on May 12, 2016(1), demonstrates the need for ... Olsen, CEO of Baltimore-based biotech firm, PathSensors, Inc. , PathSensor’s latest ...
Breaking Biology Technology: