Navigation Links
Engineered immune cells produce complete response in child with an aggressive pediatric leukemia
Date:12/9/2012

By reprogramming a 7-year-old girl's own immune cells to attack an aggressive form of childhood leukemia, a pediatric oncologist has achieved a complete response in his patient, who faced grim prospects when she relapsed after conventional treatment. The innovative experimental therapy used bioengineered T cells, custom-designed to multiply rapidly in the patient, and then destroy leukemia cells. After the treatment, the child's doctors found that she had no evidence of cancer.

Pediatric oncologist Stephan A. Grupp, M.D., Ph.D., of The Children's Hospital of Philadelphia, and colleagues from the University of Pennsylvania presented updated results of the clinical trial involving these engineered cells at the American Society of Hematology (ASH) annual meeting today in Atlanta. Grupp is the director of Translational Research for the Center for Childhood Cancer Research at The Children's Hospital of Philadelphia, and a professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.

Grupp's research builds on his ongoing collaboration with Penn scientists who originally developed the modified T cells as a treatment for B-cell leukemias. The Penn team reported on early results of a trial using this cell therapy in adult chronic lymphocytic leukemia (CLL) patients in August of 2011. Carl H. June, M.D., of the Perelman School of Medicine at the University of Pennsylvania, leads this research group, which along with Grupp's work, is presenting new data at the ASH meeting showing that nine of 12 patients with advanced leukemias in the clinical trial, including two children, responded to treatment with CTL019 cells.

One of the nine responding patients is the 7-year-old with acute lymphoblastic leukemia (ALL). Grupp and Penn colleagues adapted the treatment to combat ALL, the most common childhood leukemia, and also the most common childhood cancer. Although physicians can cure roughly 85 percent of ALL cases, the
'/>"/>

Contact: Rachel Salis-Silverman
Salis@email.chop.edu
267-970-3685
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Leukemia patients remain in remission more than 2 years after engineered T cell therapy
2. Bioengineered marine algae expands environments where biofuels can be produced
3. Soft Robotics: A groundbreaking new journal on engineered soft devices that Interact with Living Systems
4. Engineered bacteria can make the ultimate sacrifice
5. Ecologist: Genetically engineered algae for biofuel pose potential risks that should be studied
6. Success of engineered tissue depends on where its grown
7. Lab-engineered kidney project reaches early milestone
8. Engineered robot interacts with live fish
9. Engineered microvessels provide a 3-D test bed for human diseases
10. New research reveals challenges in genetically engineered crop regulatory process
11. Ultrasound idea: Prototype NIST/CU bioreactor evaluates engineered tissue while creating it
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... The work has been published in the Scientific Reports ... of Evolutionary Biology (a joint centre of CSIC and Pompeu ... Bourbons was decoded and we saw that it did not ... we decided to sequence the complete genome and to make ... could actually belong to Louis XVI". , The functional ...
(Date:4/24/2014)... by fungus could now be treated in three days, rather ... scientists. , Cryptococcus a form of yeast ... medical research. They are found in many parts of ... mainly affect people with weakened immune systems. This infection kills ... team has tested the effects of the most commonly used ...
(Date:4/24/2014)... With a new generation of military veterans returning home ... become a prominent concern in American medical institutions and ... 35 percent of personnel deployed to Iraq and Afghanistan ... South Carolina School of Medicine is shedding light on ... and surprising ways. , The rise in PTSD has ...
Breaking Biology News(10 mins):The blood preserved in the pumpkin did not belong to Louis XVI 2Treatment for deadly yeast disease reduced to 3 days 2New study links inflammation in those with PTSD to changes in microRNA 2New study links inflammation in those with PTSD to changes in microRNA 3
... . , Barcelona, Spain: Research into the effect ... reproduction technology (ART) shows that for younger women, the overwhelming ... women over the age of 40 had a more consistent, ... four attempts. Mr Simon Hong told the 24th ...
... production of alternative fuels from plant material, enzymes which ... required in industrial quantities and at a low cost. ... have come up with a solution: using plants to ... the Bioseparations Lab, will describe their research on Monday ...
... study published in the current issue of Science ... species has been increasing continuously since the origin of ... professor at Texas A&M University, has been a part ... study, which concludes that most of the diversification occurred ...
Cached Biology News:Failure of the 1st attempt at assisted reproduction justifies at least 1 additional cycle 2Failure of the 1st attempt at assisted reproduction justifies at least 1 additional cycle 3A green solution to biofuel production 2Setting the record right: species diversity less dramatic than previously believed 2
(Date:1/15/2014)... The Pittcon Organizing Committee is pleased to announce that ... an e-Journal and producer of Food Labs Conference ... for the co-location of Food Labs Conference to be held ... registration fee to attend the two-day Food Lab Conference, March ...
(Date:1/15/2014)... 15, 2014 Cynvenio, a cancer diagnostics ... the genomic analysis of tumor cells in the bloodstream, ... web-based cancer decision support application powered by CollabRx, Inc. ... ClearID™ genomic test, Therapy Finder will provide breast cancer ...
(Date:1/15/2014)... 15, 2014 This webinar will focus ... clinical safety assessment in biosimilars. , Regulatory frameworks are ... drug development, however the complex nature of biopharmaceuticals makes ... and efficacy extremely challenging. Based on the specific aspects ...
(Date:1/15/2014)... Two champions of science, technology, engineering, ... an annual competition for middle and high school students ... STEM study. The competition presents students with real-world problems ... Aptitude, Mathematics, and Sciences is a program administered ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... P. Hammer, Ph.D., director of chemical development. , ... ... (NEP), has named Robert P. Hammer, Ph.D., director of chemical development. ... where he was the William A. Pryor professor of chemistry since ...
... a laptop computer on your lap lately, you probably ... are creating more and more heat, which has to ... , Two researchers at the University of Virginia,s School ... scientific groundwork that will solve the problem using nanoelectronics, ...
... Sept. 29 Sangamo,BioSciences, Inc. (Nasdaq: SGMO ) ... provide an update on the progress of,Sangamo,s ZFP Therapeutic ... at 11:30 a.m. (ET) on Monday, October 6, 2008,at ... 8:40 a.m.,(ET) on Tuesday, October 7, 2008 at the ...
Cached Biology Technology:New England Peptide Names Director of Chemical Development 2Engineers aim to solve 'burning' computer problem 2Sangamo BioSciences to Present at Two Upcoming Investor Conferences 2
... Premixed solution for high PCR ... to the combination of enzyme with ... Reduced nonspecific amplification provided by ... Easy handling convenient Master Mix ...
Recombinant Ovine IFN Tau. Active on sheep, cow, human and mouse cells. Activity: 5.7 x 10 7 u/mg...
Request Info...
... fast and efficient microplate stacker ... capacity and reliable design allow for ... time than typical stackers. Its ... for a seamless and trouble-free installation ...
Biology Products: