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Engineer to spearhead research into cell metabolism and medical injuries
Date:5/9/2008

idealised subjects. Dr Bates will perform population modelling, making his findings applicable to real patients.

With the second grant, Dr Bates will investigate how biochemical pathways are regulated in human cells, which could lead to improved anti-cancer drugs.

A class of molecules called polyamines are crucial to the health of the cells in your body. Cells normally regulate polyamine levels very tightly as changes in their concentrations can cause the cells to die, become cancerous, or give rise to other diseases.

Understanding how various biological control processes interact to keep everything on an even keel is a tall order, and one that can only be addressed with the new field of Systems Biology.

Dr Bates will draw on the expertise of biologists and control engineers to mathematically model the pathways involved. This will teach us how the control systems operate and how cells stay healthy, but should ultimately lead to therapies specific to the problems that arise when they go wrong.

Dr. Bates says:

This interdisciplinary approach is required as a direct response to the complexity of the mechanisms being studied, which renders standard biological approaches inadequate.


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Contact: Dr. Declan Bates
dgb3@le.ac.uk
University of Leicester
Source:Eurekalert

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