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Energy-saving bacteria resist antibiotics
Date:9/2/2008

a. "As long as these additional roles do not interfere with the original function of the protein, they could benefit the cell by providing a competitive advantage during evolution."

By having multifunctional enzymes, a cell has fewer proteins to build, therefore less DNA to replicate. This means they save a great deal of energy in growth and reproduction. Moonlighting proteins can also control cellular activities, such as DNA replication in the case of MurI.

"An alarming increase in the emergence of multi-drug resistant strains of M. tuberculosis has led to an active search for novel drug targets," said Professor Nagaraja. "Our results may help us to discover molecules to target MurI, to prevent bacteria from making cell walls and develop a successful treatment for a wide range of bacterial infections."


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Contact: Lucy Goodchild
l.goodchild@sgm.ac.uk
44-011-898-81843
Society for General Microbiology
Source:Eurekalert

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