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Endothelium, heal thyself
Date:5/16/2013

inates and disrupts micro-wound healing," adds Carman. "It appears that we've got an essential homeostatic self-repair mechanism that is completely dependent on the generation of intracellular ROS, which is opposite to our typical thinking about ROS in cardiovascular health and disease."

Adds William Aird, MD, PhD, Director of BIDMC's Center for Vascular Biology Research, "These findings suggest a new way of thinking about how to deal with pathologic breakdown of the endothelial barrier. We know that a 'leaky endothelium' is a central part of the pathogenesis of a number of serious diseases, including sepsis, acute lung injury, and ischemic cardiovascular diseases, as well as chronic inflammatory conditions such as diabetes and arthritis. In addition to the presence of excessive barrier insults, it now appears that leakage can result when the endothelium loses its self-restorative capacity and its dynamic reserve to heal micro-wounds."


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Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

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