Navigation Links
Endothelium, heal thyself
Date:5/16/2013

lli, PhD, revealed that in response to micrometer-scale disruptions caused by the transmigrating leukocytes, the endothelial cells were generating unique ventral lamellipodia structures, which were then migrating to the sites of the micro-wounds to close them up. "The ventral lamellipodia were responding to the sensation of an acute loss of preexisting isometric tension," explains Martinelli, a senior scientist in the Carman laboratory, who compares the cell to a circus tent tethered in place by strategically placed ropes and stakes.

"If you cut one of the ropes holding up the tent, two things will happen," she adds. "First the part of the tent that was under tension will undergo a recoil which will lead to a relaxation, leaving one part of the tent untethered and flapping in the breeze. At the same time, the remaining sets of ropes and stakes will have to bear the extra load. In the case of the endothelial cells, this translates to a force loading event."

Existing studies have focused almost exclusively on force loading (physical pulling or tugging on cells) as response triggers. But by using new devices, the team was able to push, prod, stretch and unstretch cells in very specific ways. "Our experiments told us that endothelial micro-wounding is actually a tension-loss signal [i.e. force unloading] and that this signal cued the recovery response," adds Carman. This response, he adds, is fundamentally dependent on proteins (i.e. NADPH oxidases) that can generate reactive oxygen species (ROS), specifically hydrogen peroxide.

ROS are widely implicated in causing cellular, tissue and organ damage when present at excessive levels in the body. But, these findings show that low levels of these molecules when produced in discrete locations within the cell are highly protective. "It's tempting to speculate that excess ROS causes vascular breakdown by short-circuiting the recuperative response process and creating 'white noise' that dis-coord
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3 4

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Aug. 21, 2014 Nxt-ID, Inc. (OTCQB: ... mobile commerce market, announced today that its shares of ... to be issued in its proposed underwritten public offering ... listing on The Nasdaq Capital Market, subject to closing ... stock and warrants, and will trade under the symbol ...
(Date:8/21/2014)... and other itchy, flaky maladies in humans has now ... reefs and the extreme environments of arctic soils and ... journal PLOS Pathogens considers the diversity, ecology, ... Malassezia in light of new insights gained from ... University of Hawai,i at Mānoa scientist Anthony Amend discovered ...
(Date:8/21/2014)... -- Nine researchers from Beth Israel Deaconess ... in "The World,s Most Influential Scientific Minds 2014," ... Thomson Reuters ScienceWatch, a web resource for science metrics ... recognized as among the most influential "are performing and ... the advancement of their science," according to a Thomson ...
Breaking Biology News(10 mins):Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3
... primitive Earth mantle reservoir on Baffin Island in the Canadian ... collaboration report the finding--the first discovery of what may be ... . The Earth,s mantle is a rocky, solid shell ... and makes up about 84 percent of the Earth,s volume. ...
... of yellow haze hovering over Houston as a result of ... a little bit thinner, according to a new study. ... petrochemical-producing cities around the world -- come with a catch, ... Research in Environmental Sciences, or CIRES, a joint institute of ...
... Blish, M.D., Ph.D., Acting Instructor in Medicine, University of ... Research Center, Seattle, has been chosen by the American ... Young Investigator Award for her outstanding work elucidating the ... by Merck, U.S. Human Health Division, this award recognizes ...
Cached Biology News:Oldest Earth mantle reservoir discovered 2Texas petrochemical emissions down, but still underestimated, says study 2
(Date:8/22/2014)... 22nd), in the scientific journal PLoS One ... the effect of serotonin on sensitivity to pain ... techniques., "Serotonin is a small molecule known to ... functions, from the control of sleep and appetite, ... neurotransmitter is also popularly thought to contribute to ...
(Date:8/22/2014)... gold particles are intensively investigated for application ... contrast agents and components in photonics and ... structures, fundamental for understanding physical and chemical ... Stanford University, USA, have demonstrated that high-resolution ... a three-dimensional structure in which all gold ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 The Global ... in-depth study on the current state of the Diabetes ... provides a basic overview of the industry, including definitions, ... Chinese domestic market analysis are provided with a focus ... market. A comparison between the international and Chinese situation ...
(Date:8/22/2014)... Research and Markets has announced the addition ... Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - ... The global molecular biology enzymes market was ... to grow at a CAGR of 13.74% to reach ... reagents find applications in a large number of fields ...
Breaking Biology Technology:From happiness to pain: Understanding serotonin's function 2A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 3Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 3
... in 131.4% Increase in Revenue and Positive ... EBITDA for Three Consecutive Quarters, PRINCETON, ... development and protein production company, today,announced record growth in revenues ... period last year and generated positive EBITDA for,the third consecutive ...
... is so 2007. This,year scientists in North Carolina have ... Going Blue., This new charge is coming out ... country,s newest business incubators that,discovers, develops and markets new ... Blue initiative broadens the focus of environmental awareness,from land-based ...
... With Regional Perspective, PHILADELPHIA and LONDON, April ... information solutions to the worldwide,research and business communities, ... been added to Web of Science. The newly ... rather than,international audience by approaching subjects from a ...
Cached Biology Technology:Laureate Pharma Reports Record Growth for 2007 2Laureate Pharma Reports Record Growth for 2007 3When it Comes to Going Green, These N.C. Scientists are Singing the Blues 2Thomson Scientific Begins Expansion of Web of Science 2
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... The LIC Duet™ T7•Tag ® ... lac operator, ribosome binding site (rbs), ... T7•Tag coding sequence. The T7•Tag is a ... useful for detection of the target protein ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
Mouse monoclonal antibody to QARS - glutaminyl-tRNA synthetase...
Biology Products: