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Endothelin receptor may play role in sickle cell pain
Date:9/10/2009

pain. That is because ETBR resides in many places within the body, including the cells that make up skin.

When the receptor is activated, it releases endorphins (the body's natural opiate) throughout the body. "We are finding that the males who experience repeated pain do not have as much of the receptor and therefore do not release as much of the endorphins," Sweitzer explained.

Conversely, the team has found that females have more of the ETB receptor. "Females experience better pain control and have more of the receptor. This juxtaposition may help explain sensitivity by gender. The difference in the endothelin receptor may help explain why we are finding males more sensitized to pain."


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Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

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