Navigation Links
Endometrial stem cells could repair brain cells damaged by Parkinson's disease
Date:5/6/2010

Stem cells derived from the endometrium (uterine lining) and transplanted into the brains of laboratory mice with Parkinson's disease appear to restore functioning of brain cells damaged by the disease, according to a new study by Yale School of Medicine researchers.

The findings are published in the Journal of Cellular and Molecular Medicine. Although these are preliminary results, the findings increase the likelihood that endometrial tissue could be harvested from women with Parkinson's disease and used to re-grow brain areas that have been damaged by the disease, according to lead author Hugh S. Taylor, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine, and section chief of Reproductive Endocrinology and Infertility at Yale School of Medicine.

Because of their ability to divide into new cell types, stem cells could be the key to treating many different kinds of diseases, like Parkinson's, in which the body's own cells are damaged or depleted. Parkinson's is caused by a breakdown of dopamine-producing nerve cells in the brain stem. Dopamine is a neurotransmitter that stimulates the motor neurons that in turn control muscles. When dopamine production is reduced, the nerves are not able to control movement or maintain coordination.

In their study, Taylor and his colleagues collected and cultured endometrial tissue from nine women, and verified that they could be transformed into dopamine-producing nerve cells like those in the brain.

"The dopamine levels in the mice increased once we transferred the endometrial stem cells into their brains," said Taylor. "This is encouraging because women have a ready supply of stem cells that are easily obtained, can differentiate into other cell types. They may have great potential for treating multiple diseases."

Highlighting the benefits of using endometrial stem cells, Taylor said the ethical concerns surrounding the use of embryonic stem cells are eliminated when using adult stem cells. Taylor also points out that endometrial stem cells are one of the best sources for generating neurons because they appear to be less likely to be rejected than stem cells from other sources.

"This is just the tip of the iceberg of what we will be able to do with these cells," said Taylor. "We believe these neurons are only the first of many cell types derived from endometrium that will be used to treat a variety of diseases."


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert  

Related biology news :

1. A potent suppressor of endometrial cancer is revealed
2. TGen and Washington University researchers discover new approach to treating endometrial cancer
3. Caught on tape: Muscle stem cells captured on video by MU researcher
4. Male or female? In flies, some cells cant tell
5. Broccoli component limits breast cancer stem cells, U-M study finds
6. Scripps Research team provides groundbreaking new understanding of stem cells
7. California funds UCI basic research on stem cells
8. Lensless imaging of whole biological cells with soft X-rays
9. Innovalight Establishes New Record With Silicon Ink Solar Cells
10. Gene silencing may be responsible for induced pluripotent stem cells limitations
11. Production of biofuels could benefit by controlling the types of cells that develop in plants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Endometrial stem cells could repair brain cells damaged by Parkinson's disease
(Date:5/16/2016)... 16, 2016   EyeLock LLC , a market ... opening of an IoT Center of Excellence in ... the development of embedded iris biometric applications. ... convenience and security with unmatched biometric accuracy, making it ... from DNA. EyeLock,s platform uses video technology to deliver ...
(Date:5/9/2016)... UAE, May 9, 2016 Elevay ... comes to expanding freedom for high net worth professionals ... in today,s globally connected world, there is still no ... could ever duplicate sealing your deal with a firm ... passports by taking advantage of citizenship via investment programs ...
(Date:4/28/2016)... FRANCISCO and BANGALORE, India , ... of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... provider, today announced a global partnership that will ... way to use mobile banking and payment services. ... is a key innovation area for financial services, but it ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
Breaking Biology Technology: