Navigation Links
Endometrial stem cells could repair brain cells damaged by Parkinson's disease

Stem cells derived from the endometrium (uterine lining) and transplanted into the brains of laboratory mice with Parkinson's disease appear to restore functioning of brain cells damaged by the disease, according to a new study by Yale School of Medicine researchers.

The findings are published in the Journal of Cellular and Molecular Medicine. Although these are preliminary results, the findings increase the likelihood that endometrial tissue could be harvested from women with Parkinson's disease and used to re-grow brain areas that have been damaged by the disease, according to lead author Hugh S. Taylor, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine, and section chief of Reproductive Endocrinology and Infertility at Yale School of Medicine.

Because of their ability to divide into new cell types, stem cells could be the key to treating many different kinds of diseases, like Parkinson's, in which the body's own cells are damaged or depleted. Parkinson's is caused by a breakdown of dopamine-producing nerve cells in the brain stem. Dopamine is a neurotransmitter that stimulates the motor neurons that in turn control muscles. When dopamine production is reduced, the nerves are not able to control movement or maintain coordination.

In their study, Taylor and his colleagues collected and cultured endometrial tissue from nine women, and verified that they could be transformed into dopamine-producing nerve cells like those in the brain.

"The dopamine levels in the mice increased once we transferred the endometrial stem cells into their brains," said Taylor. "This is encouraging because women have a ready supply of stem cells that are easily obtained, can differentiate into other cell types. They may have great potential for treating multiple diseases."

Highlighting the benefits of using endometrial stem cells, Taylor said the ethical concerns surrounding the use of embryonic stem cells are eliminated when using adult stem cells. Taylor also points out that endometrial stem cells are one of the best sources for generating neurons because they appear to be less likely to be rejected than stem cells from other sources.

"This is just the tip of the iceberg of what we will be able to do with these cells," said Taylor. "We believe these neurons are only the first of many cell types derived from endometrium that will be used to treat a variety of diseases."


Contact: Karen N. Peart
Yale University

Related biology news :

1. A potent suppressor of endometrial cancer is revealed
2. TGen and Washington University researchers discover new approach to treating endometrial cancer
3. Caught on tape: Muscle stem cells captured on video by MU researcher
4. Male or female? In flies, some cells cant tell
5. Broccoli component limits breast cancer stem cells, U-M study finds
6. Scripps Research team provides groundbreaking new understanding of stem cells
7. California funds UCI basic research on stem cells
8. Lensless imaging of whole biological cells with soft X-rays
9. Innovalight Establishes New Record With Silicon Ink Solar Cells
10. Gene silencing may be responsible for induced pluripotent stem cells limitations
11. Production of biofuels could benefit by controlling the types of cells that develop in plants
Post Your Comments:
Related Image:
Endometrial stem cells could repair brain cells damaged by Parkinson's disease
(Date:10/13/2015)... Global Next Generation Biometric Market ... . --> Mordor Intelligence is pleased to ... Generation Biometric Market . ) ... ) --> ... to increase to $23.8 billion by 2020 at a ...
(Date:10/12/2015)... , October 12, 2015 ... new market research report on the "Digital Security Control ... & Security Token), by Software (Anti-Phishing, Authentication, Network Surveillance, ... 2020", published by MarketsandMarkets, the market is expected to ... 2020, and reach USD 14.6 Billion by 2020. ...
(Date:10/12/2015)... , Oct. 9, 2015 Research and Markets ... Research, Inc,s new report "Biometrics: Market Shares, Strategies, ... --> --> The ... the Biometrics market segment. Research represents a selection from ... and cogent market materials, with selections made by the ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... ... ... Clinovo recently appointed Jeff Parr and Ed Donaldson to its Business Development Management ... Jeff Parr has spent the past decade providing quality management software and consulting services ... Sciex to name a few. He is based in Salt Lake City, a ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... technologies, announced today that it received de novo clearance from the U.S. Food ... for the ablation of prostate tissue. Sonablate® is the first High Intensity Therapeutic ...
(Date:10/13/2015)... ... October 13, 2015 , ... Proove Biosciences, ... announce their partnership with the Keck Medicine of the University of Southern ... The T.R.O.J.A.N. Study (Therapeutic Evaluation to Research Clinical Objectives Linking Genotypic and Phenotypic ...
(Date:10/13/2015)... Jersey (PRWEB) , ... October 13, 2015 , ... ... enhance the educational opportunities for school age children in the areas of Science, ... for all sectors of the national economy, and the program aims to increase ...
Breaking Biology Technology: