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Emerging importance of computerized cognitive testing -- new therapies for dementia
Date:7/18/2013

nd memory can be improved by memantine in two other major forms of dementia - Parkinson's disease dementia and dementia with Lewy Bodies. The improvements detected were highly statistically reliable and of clinically relevant effect sizes; indicating that memantine can produce cognitive benefits in patients with these dementias which match those seen previously with anticholinesterases.

Both studies utilised the CDR System, an automated cognitive test system, making a strong case for benefits for the increased sensitivity and specificity that such procedures bring to dementia research, when compared with the traditional tests which have been historically employed.

Another recent Alzheimer's trial conducted by Orion Corporation demonstrated proof of concept of a new drug with a novel mode of action. The phase II clinical trial tested ORM-12741 -- the first drug to target a specific subtype of adrenergic receptors (alpha-2c) in the brain, which are believed to be involved in modulation of brain functions under stressful conditions. The trial of 100 patients showed significant positive effects on episodic memory in patients with moderate Alzheimer's disease. Efficacy was assessed using the CDR System.


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Contact: Annette Larkin
larkinannette@yahoo.com
703-772-6427
Bracket Global
Source:Eurekalert

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