Navigation Links
Emerging importance of computerized cognitive testing -- new therapies for dementia
Date:7/18/2013

Boston, MA Computerized cognitive testing is increasingly playing a key role in therapy development for dementia and Alzheimer's disease. This week at the Alzheimer's Association International Conference, Keith Wesnes Ph.D., Practice Leader of Bracket and founder of the CDR System, discussed new data for novel therapies at two poster presentations at the Alzheimer's Association International Conference.

Poster Title: Cognitive evidence in Alzheimer's disease patients that compromised hippocampal neurogenesis is related both to APOE4 status and CSF Abeta42

This presentation provides the first behavioural data in Alzheimer's patients which associates genetic and biomarker activity to dysfunction in a major brain area involved both in memory and the production of new nerve cells (neurogenesis), This exciting finding obtained in collaboration with a group including Kaj Blennow, University of Gothenburg, found that patients with two APOE ϵ4 alleles (which confer a 10 to 30 fold increased risk of developing Alzheimer's disease) showed a selective decline in a computerised cognitive test measure associated with activity in the hippocampal dentate gyrus. Furthermore, in all patients studied, this test measure was more closely associated with the levels of the Aβ42 biomarker for the disease than a number of other memory measures associated with different hippocampal regions.

As interest in Alzheimer's research is shifting to begin treating the disease at its earliest stages, these findings identify a potential genetic and biomarker strategy for selecting individuals for early treatment with therapies which may promote hippocampal neurogenesis.

Poster Title: Memantine improves attention and verbal episodic memory in Parkinson's disease dementia and dementia with Lewy bodies: a double-blind placebo-controlled multicentre trial

A second presentation provides the first data that performance on objective tests of attention and memory can be improved by memantine in two other major forms of dementia - Parkinson's disease dementia and dementia with Lewy Bodies. The improvements detected were highly statistically reliable and of clinically relevant effect sizes; indicating that memantine can produce cognitive benefits in patients with these dementias which match those seen previously with anticholinesterases.

Both studies utilised the CDR System, an automated cognitive test system, making a strong case for benefits for the increased sensitivity and specificity that such procedures bring to dementia research, when compared with the traditional tests which have been historically employed.

Another recent Alzheimer's trial conducted by Orion Corporation demonstrated proof of concept of a new drug with a novel mode of action. The phase II clinical trial tested ORM-12741 -- the first drug to target a specific subtype of adrenergic receptors (alpha-2c) in the brain, which are believed to be involved in modulation of brain functions under stressful conditions. The trial of 100 patients showed significant positive effects on episodic memory in patients with moderate Alzheimer's disease. Efficacy was assessed using the CDR System.


'/>"/>

Contact: Annette Larkin
larkinannette@yahoo.com
703-772-6427
Bracket Global
Source:Eurekalert

Related biology news :

1. UF researchers look for ways to make an emerging technology safe for environment
2. Updates in Interventional Radiology accents emerging trends, practice growth
3. DNA Sequencing: Emerging Technologies and Applications
4. Malaysia to battle nutrition transition problem emerging worldwide: More income, poorer diet choices
5. Scientists question the designation of some emerging diseases
6. Emerging virus in raccoons may provide cancer clues
7. Nanoparticle researcher will inaugurate prestigious emerging leaders lecture series
8. Press registration open for ASM Biodefense and Emerging Diseases Research Meeting
9. Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
10. Watering the forest for the trees emerging as priority for forest management
11. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2016)... 2016 http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) ... "Global Biometrics as a Service Market 2016-2020" ... --> http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced the ... a Service Market 2016-2020" report to ... and Markets ( http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced ...
(Date:3/1/2016)... FRANCISCO , March 1, 2016  (RSAC Booth ... year, but a whopping $118 billion is lost to ... to overzealous and inaccurate fraud detection. At the RSA ... in the way companies handle authentication by devaluing the ... and behavioral analytics. --> ...
(Date:2/26/2016)... Feb. 26, 2016 ... the "Biometrics Market in MENA: Research ... to their offering. --> ... the "Biometrics Market in MENA: Research ... to their offering. --> ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... made significant investments in recruiting top industry experts, and expanding its LATAM network ... provides industry-leading tools for clients to manage their clinical trial projects. , The ...
(Date:4/27/2016)... ... 27, 2016 , ... Cambridge Semantics, the leading provider of Smart ... it has been named to The Silicon Review’s “20 Fastest Growing Big Data Companies ... Semantics serves the needs of end users facing some of the most complex data ...
(Date:4/27/2016)... ... ... The Pittcon Organizing Committee is pleased to announce that Charles “Chuck” Gardner ... Committee since 1987. Since then, he has served in a number of key leadership ... both the program and exposition committees. In his professional career, Dr. Gardner is the ...
(Date:4/27/2016)... 27, 2016 NanoStruck Technologies ... NSKQB) ( Frankfurt : 8NSK) gibt ... vom 13. August 2015 die Genehmigung von der ... zusätzliche 200.000.000 Einheiten auf 400.000.000 Einheiten zu erhöhen, ... Davon wurden 157.900.000 Einheiten mit dem ersten Teil ...
Breaking Biology Technology: