Navigation Links
Emerging class of therapeutics represents a coming wave for developers and manufacturers
Date:1/22/2014

After years of research, development and testing, a new class of drugs is emerging on the market with two frontrunners acting as harbingers of what's to come. The cover story in Chemical & Engineering News, ACS' weekly newsmagazine, explores the potential of these antibody-drug conjugates (ADCs) and the challenges in developing and manufacturing them.

Ann M. Thayer, senior correspondent at C&EN, explains that ADCs are essentially molecular missiles. They are made up of a toxic payload (a drug) attached to an antibody that specifically seeks out sick cells, such as tumor cells. They don't release their lethal cargo until they reach their target. The advantages of this approach are clear: It spares healthy cells and lowers drug side effects. It can also extend the life of a drug under an expiring patent or salvage an antibody that was ineffective by itself. ADCs hold a lot of promise. Of the two approved ADCs, one is soon expected to be a blockbuster. About 30 more are in clinical trials with another 100 or more ADCs in the preclinical pipeline. Projections show that by 2018, sales of ADCs could top $5 billion.

On the manufacturing side, because these drugs are so complex, suppliers are still figuring out how to streamline production. At the moment, ADCs are a niche area of manufacturing with only a few contract manufacturing organizations able to put all the pieces together from start to finish. But many are responding and investing millions to expand capacity for this promising new class.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. UF researchers look for ways to make an emerging technology safe for environment
2. Updates in Interventional Radiology accents emerging trends, practice growth
3. DNA Sequencing: Emerging Technologies and Applications
4. Malaysia to battle nutrition transition problem emerging worldwide: More income, poorer diet choices
5. Scientists question the designation of some emerging diseases
6. Emerging virus in raccoons may provide cancer clues
7. Nanoparticle researcher will inaugurate prestigious emerging leaders lecture series
8. Press registration open for ASM Biodefense and Emerging Diseases Research Meeting
9. Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
10. Watering the forest for the trees emerging as priority for forest management
11. Emerging importance of computerized cognitive testing -- new therapies for dementia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2018)... MELBOURNE, Fla. (PRWEB) , ... August 15, 2018 , ... ... will be the NEW FX 635 Laser’s unveiling. Doctors from around the U.S. ... With the NEW FX 635, Erchonia Corporation completed another successful clinical trial ...
(Date:8/14/2018)... ... August 14, 2018 , ... ... for the global scientific community, announced today the establishment of a new Scientific ... is to foster and support scientific collaborations with ActiGraph’s academic and pharmaceutical industry ...
(Date:8/9/2018)... ... August 09, 2018 , ... CRB is proud to ... has won Engineering News-Record (ENR) Texas & Louisiana’s 2018 Best Projects in the ... competition. The judges selected 42 projects across 18 categories as the region’s best. ...
Breaking Biology News(10 mins):
(Date:8/1/2018)... ... August 01, 2018 , ... ... results on the significant impact of a proprietary biofield energy treated supplement ... preclinical research assessed biomarkers for systemic and organ-specific inflammation, as well as, ...
(Date:7/31/2018)... ... 31, 2018 , ... Mahoney Environmental , a leading ... new website. The new website has been designed with improved functionality and navigation, ... Innovative to build a website created for the customer. The newly redesigned site ...
(Date:7/25/2018)... ... July 25, 2018 , ... Eileen ... impact of a biofield energy treated nutraceutical to improve skin health parameters including ... for skin health and reported the following results:,     More ...
(Date:7/25/2018)... Fla. (PRWEB) , ... July 25, 2018 , ... ... Podiatric Medicine (NYCPM) & Foot Center of New York’s (FCNY) acquisition of several ... provides unrivaled excellence in podiatric medical education and clinical experience. Their students ...
Breaking Biology Technology: