Navigation Links
Emerging class of therapeutics represents a coming wave for developers and manufacturers
Date:1/22/2014

After years of research, development and testing, a new class of drugs is emerging on the market with two frontrunners acting as harbingers of what's to come. The cover story in Chemical & Engineering News, ACS' weekly newsmagazine, explores the potential of these antibody-drug conjugates (ADCs) and the challenges in developing and manufacturing them.

Ann M. Thayer, senior correspondent at C&EN, explains that ADCs are essentially molecular missiles. They are made up of a toxic payload (a drug) attached to an antibody that specifically seeks out sick cells, such as tumor cells. They don't release their lethal cargo until they reach their target. The advantages of this approach are clear: It spares healthy cells and lowers drug side effects. It can also extend the life of a drug under an expiring patent or salvage an antibody that was ineffective by itself. ADCs hold a lot of promise. Of the two approved ADCs, one is soon expected to be a blockbuster. About 30 more are in clinical trials with another 100 or more ADCs in the preclinical pipeline. Projections show that by 2018, sales of ADCs could top $5 billion.

On the manufacturing side, because these drugs are so complex, suppliers are still figuring out how to streamline production. At the moment, ADCs are a niche area of manufacturing with only a few contract manufacturing organizations able to put all the pieces together from start to finish. But many are responding and investing millions to expand capacity for this promising new class.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. UF researchers look for ways to make an emerging technology safe for environment
2. Updates in Interventional Radiology accents emerging trends, practice growth
3. DNA Sequencing: Emerging Technologies and Applications
4. Malaysia to battle nutrition transition problem emerging worldwide: More income, poorer diet choices
5. Scientists question the designation of some emerging diseases
6. Emerging virus in raccoons may provide cancer clues
7. Nanoparticle researcher will inaugurate prestigious emerging leaders lecture series
8. Press registration open for ASM Biodefense and Emerging Diseases Research Meeting
9. Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
10. Watering the forest for the trees emerging as priority for forest management
11. Emerging importance of computerized cognitive testing -- new therapies for dementia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2019)... ... May 21, 2019 , ... ... will we know? How can we tell it apart from the millions of ... by a multi-institution research team, including Eric Young , assistant professor of ...
(Date:5/21/2019)... ... ... Suvoda LLC , a SaaS provider of Interactive Response Technology (IRT) for ... Magazine’s Best Workplaces for 2019, Inc.’s fourth annual ranking of the fast-growing private company ... newsstands on May 28, is the result of a comprehensive measurement of private American ...
(Date:5/21/2019)... , ... May 20, 2019 , ... Dr. David ... acclaimed documentary. The documentary, Stem Cell Therapy: Biotechnology to the Rescue, was produced by ... long, Dr. Greene was interviewed in regards to the safety of the procedures along ...
Breaking Biology News(10 mins):
(Date:5/21/2019)... ... May 21, 2019 , ... DuPont Nutrition & ... the inaugural Africa Brewing Conference dedicated to sharing brewing knowledge, strengthening relationships and ... which is supported through a partnership with “Ethiopia Invest”, will run through May ...
(Date:5/8/2019)... , ... May 07, 2019 , ... Standing at 16.2 hands, Atlas is on the ... in a drill team and barrel racing, among other activities. When loping around a ... He went from being a busy horse to only being able to walk. Fortunately ...
(Date:5/2/2019)... ... ... The centuries old practice of brewing beer thrives today across a wide ... home brewing clubs scattered across the nation. , But proper beer brewing, on ... a superb product. Students at South Dakota School of Mines & Technology ...
(Date:4/25/2019)... ... April 24, 2019 , ... Inference Solutions , ... organizations, today announced global availability of Inference Studio’s latest version, which makes it ... to harness the power of Google’s Contact Center AI (CCAI). , ...
Breaking Biology Technology: