Navigation Links
Emergency alert in the cell
Date:2/28/2014

When an organism is exposed to life-threatening conditions, it sounds the alarm and a cellular emergency program, the heat shock response, is initiated. However, the name "heat shock response" is misleading. In the beginning of the 1960s, this form of stress response was first observed. Scientists exposed fruit flies to high temperatures and discovered a complex emergency program designated to save single cells and thus the organism itself. Today researchers know that this program is also triggered by other dangers such as radiation or toxic substances. The terminology, however, is still in use.

During the heat shock response, different stress proteins are synthesized. Their task is to prevent permanent damage to the organism. "You can compare it to an emergency alert. In order to restore the original status as soon as possible, problems and damages are identified, counter-measures initiated and coordinated", Loew describes the processes in the cell. In a comprehensive analysis, the Max Planck scientists have investigated 15 000 proteins and their role in the heat shock response. They could show that the helpers are organized in different groups according to their tasks and disaster zones. One group of proteins, for instance, checks whether the DNA in the nucleus is still intact.

The protein HSF1 (short for heat shock transcription factor) is responsible for the central coordination of the disaster management. In the moment it is activated, it calls a variety of other proteins into action to eliminate the damages. The scientists could demonstrate two ways in which this control center in itself is regulated. When the crisis is overcome, HSF1 is degraded by the cell's waste disposal system, the proteasome. As long as there is still damage to get rid of, another protein (Acetyltransferase EP300) prevents the degradation.

The understanding of the heat shock response could also be of interest for neurodegenerative diseases such as Alzheimer's or Parkinson's, so the scientists in Martinsried hope. Typical for these diseases are massive cell damages and, thus, the excessive demand on the cellular quality control. Nerve cells die and cannot fulfill their tasks in the brain anymore. "A targeted activation of the heat shock response could reduce the disease specific cell damages," explains Loew.


'/>"/>
Contact: Anja Konschak
konschak@biochem.mpg.de
49-898-578-2824
Max Planck Institute of Biochemistry
Source:Eurekalert  

Related biology news :

1. The aging population and emergency departments
2. RIH study: Emergency patients prefer technology-based interventions for behavioral issues
3. Red alert: Body kills spontaneous blood cancers on a daily basis
4. Media alert: Society of Interventional Radiologys Annual Scientific Meeting
5. New Brain Supplement Focus Boost Launches, Boosting Alertness, Memory and Focus
6. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
7. How alert hospital employees improved hospitals MSRA infection rate
8. Buttercups alert farmers to first signs of subarctic fungus in the UK
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Emergency alert in the cell
(Date:1/22/2016)... , Jan. 22, 2016 ... addition of the "Global Biometrics Market ... their offering. --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ... "Global Biometrics Market in Retail Sector ... --> Research and Markets ( ...
(Date:1/20/2016)... Jan. 20, 2016 A market that just ... benefit from the explosion in genomics knowledge. Learn all ... Research. A range of dynamic trends are pushing market ... personalized medicine - pharmacogenomics - pathogen evolution - next ... markets - greater understanding of the role of genetic ...
(Date:1/20/2016)... , Jan. 20, 2016  Synaptics Incorporated ... human interface solutions, today announced sampling of S1423, ... for wearables and small screen applications including smartwatches, ... printers. Supporting round and rectangular shapes, as well ... excellent performance with moisture on screen, while wearing ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 11, 2016  Wellcentive today announced it has ... Oregon -based community care organization (CCO) with ... analytics, quality reporting and care management solutions and ... team of quality managers, analysts and care managers ... groups serving FamilyCare members. ...
(Date:2/11/2016)... BEACH, Florida , February 11, 2016 /PRNewswire/ ... PositiveID Corporation ("PositiveID" or "Company") (OTCQB: PSID), ... diagnostics, announced today that its Thermomedics subsidiary, which ... progress on its growth plan in January 2016, ... products distributors, increasing sequential monthly sales growth, and ...
(Date:2/11/2016)... ... February 11, 2016 , ... Global Stem Cells Group, ... Bankok,Thailand-based Global Stem Cells Network (GSCN) to distribute exosome injection and other biological ... Mexico, Costa Rica, Dominican Republic, Colombia, Argentina, Nicaragua, Panama, El Salvador, Venezuela, Peru, ...
(Date:2/10/2016)... February 10, 2016 Early-career researchers ... Peru , Uganda and ... in health and nutrition   Indonesia , ... and Yemen are being honored for ... They are also celebrated for mentoring young women scientists who are pursuing ...
Breaking Biology Technology: