Navigation Links
Embryonic stem cell strategy advanced with UCSF finding
Date:9/11/2007

UCSF scientists are reporting what they say is a significant improvement in the technique for genetically reprogramming mouse cells to their embryonic state, a process that transforms the cells, in essence, into embryonic stem cells.

The finding, published on-line as an immediate early publication in Cell Stem Cell (Sept. 6, 2007), builds on the strategic breakthrough reported by Shinya Yamanaka, MD, PhD, in 2006, and confirmed in the spring of 2007 both by Yamanakas team and, in independent studies, by scientists at MIT, Harvard and UCLA.

The advance by the UCSF team should accelerate research aimed at improving the original strategy, the team says, and increase its potential use for studying disease development and creating patient-specific stem-cell based therapies.

The work is the result of a collaboration between the labs of Miguel Ramalho-Santos, PhD, and Robert Blelloch, MD, PhD, of the UCSF Institute for Regeneration Medicine.

The new technique removes a major technical hurdle that has likely discouraged many labs around the world from carrying out studies on the strategy, says senior author Ramalho-Santos, a UCSF Fellow and a member of the Diabetes Center. For separate reasons, he says, removal of the hurdle increases the techniques potential use in developing patient-specific cellular therapies.

Now, laboratories will be able to use the approach to study a broad range of normal and diseased cells of interest, says the first author of the study, Blelloch, an assistant professor of urology. There will be a much greater ability to precisely dissect the mechanisms of reprogramming and to identify the genes that will be most effective in transforming adult cells.

Yamanakas strategy -- over-expressing certain genes in mouse skin cells to initiate reprogramming relied on the insertion of a foreign drug resistance gene into the mouse skin cells. This gene would switch on in those cells that successfully
'/>"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Priming embryonic stem cells to fulfill their promise
2. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
3. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
4. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
5. Researchers devise way to mass-produce embryonic stem cells
6. Protein helps regulate the genes of embryonic stem cells
7. Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers
8. Vitamin As paradoxical role in influencing symmetry during embryonic development revealed
9. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
10. Canadas first embryonic stem cell lines
11. Researchers make embryonic-like stem cells from umbilical cord blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2014)... 2, 2014   Marvin Test Solutions , ... solutions for military, aerospace, and manufacturing organizations, today ... successful TS-900 PXI semiconductor test platform . ... high-end systems to customers at a fraction of ... traditional ATE. "Our semiconductor customers ...
(Date:11/21/2014)... According to a new market ... RFID, Access Control, Intrusion Detection, Parking Management, Under Vehicle ... Service Geography - Global Forecasts to 2020", published by ... be around $25 Billion in 2014 and is expected ... CAGR of 8.69%. Browse 116 market data ...
(Date:11/21/2014)... 2014 Strict laws against distracted driving and ... North American and European automotive sector towards gesture recognition ... systems that are intuitive and able to retrieve information ... New analysis from Frost & Sullivan,s ... Europe and North ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... 14, 2011 DERMALOG Identification Systems GmbH ... new world record in the identification of fingerprints. The ... capable of correctly identifying the ten fingerprints of one ... than 129 million fingerprints. The renowned international SGS INSTITUT ...
... An estimated 300,000 people in North America are afflicted ... of motor control. Patients with generalized dystonia grapple with ... turning in awkward, sometimes painful postures. Although cognition, intelligence ... have a devastating impact on quality of life, as ...
... Scientists are another step closer to understanding what drives ... inside tumors that can slow their own growth. ... a journal of the American Association for Cancer Research, ... division of experimental medicine at the National Academy of ...
Cached Biology News:World Record in Fingerprint Identification: DERMALOG Correctly Identifies 129 Million Fingerprints in one Second 2World Record in Fingerprint Identification: DERMALOG Correctly Identifies 129 Million Fingerprints in one Second 3University Hospitals Case Medical Center unlocks mystery of dystonia with advanced imaging 2University Hospitals Case Medical Center unlocks mystery of dystonia with advanced imaging 3
(Date:12/24/2014)... ST. LOUIS , Dec. 23, 2014 /PRNewswire/ ... announced today that the waiting period under the ... with the acquisition expired on December 22, 2014, ... and review requirement for the acquisition of the ... U.S. antitrust clearance satisfies another condition to ...
(Date:12/24/2014)... and NEW YORK , ... from its open-label pilot study of mazindol in children ... Development and Therapy in December 2014 . ... mazindol in children with attention deficit/hyperactivity disorder" ( Konofal ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) shows ...
(Date:12/22/2014)... , Dec. 22, 2014   Synthetic ... developer of pathogen-specific therapies for serious infections ... the microbiome, today announced positive topline safety ... clinical trial of SYN-004, the Company,s investigational ... Clostridium difficile (C. difficile) infection, ...
(Date:12/22/2014)... Dec. 22, 2014  Alternative Energy & Environmental ... has signed a letter of intent to acquire ... and patented a nanotechnology-based development platform used to ... enable rapid on-site collection and testing to identify ... issues in an immediate, non-invasive and cost-effective manner. ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5ALNE Announces Intention To Acquire BioTechPharma 2
... Metabolomx, a diagnostic company focused on breath analysis ... was awarded a Small Business Innovation Research (SBIR) contract ... combined Phase I/II Fast-Track contract will support the research ... lung cancer. Metabolomx, proprietary technology is designed ...
... N.J., Oct. 21, 2011  Palatin Technologies, Inc. (NYSE Amex: ... the 10th Annual BIO Investor Forum on Wednesday, October 26, ... Industry Organization (BIO), the 10th Annual BIO Investor Forum will ... Francisco, CA.  Carl Spana, Ph.D., President and ...
... Reserve University have made an electrochemical cell that uses ... of metal. The technology may open new pathways ... hydrogen fuel and synthesizing nanomaterials and polymers. A ... online edition of the Journal of the American ...
Cached Biology Technology:Metabolomx Awarded $1.14 Million SBIR Grant from National Cancer Institute for Breath Analysis Test of Lung Cancer 2Electrochemistry controlled with a plasma electrode 2
LIVE/DEAD® Cell-Mediated Cytotoxicity Kit *for animal cells* *2000 assays*...
... Light Antifade Kit is an aqueous-based mounting ... fluorescent dyes. This formulation of antifade minimizes ... Cascade Blue fluorophores that is often seen ... is available with the blue-fluorescent nucleic acid ...
Human Xg Affinity Purified Polyclonal Ab Keywords: Xg glycoprotein, hereditary hemorrhagic telangiectasia Protein Family: ...
in vitro Translation, Accessory Products...
Biology Products: