Navigation Links
Embryonic heart exhibits impressive regenerative capacity
Date:10/13/2008

A new study demonstrates that the embryonic mouse heart has an astounding capacity to regenerate, a phenomenon previously observed only in non-mammalian species. The research, published by Cell Press in the October 14th issue of the journal Developmental Cell, describes the previously unrecognized potential of the embryonic heart to replace diseased tissue through compensatory proliferation of healthy cells.

Disorders of the mitochondria, a cell structure required for energy production, are one of the leading causes of fatal early onset cardiomyopathies. To investigate how mutations that interfere with mitochondrial function impact the heart during development, Professor Timothy C. Cox (from the University of Washington in Seattle) and colleagues used a heart-specific knockout approach in mice to inactivate a gene crucial for normal mitochondrial function. Their experimental methods established embryonic female mice with mosaic hearts composed of mixed cell populations: half normal and half "diseased" (lacking the gene). However, surprisingly, at birth the diseased cells represented only about 10% of the cardiac tissue.

The authors went on to show that increased proliferation of healthy heart cells was responsible for this change and led to a fully functional heart. Nevertheless, despite normal cardiac function early in life, over 40% of adult mice prematurely developed cardiac pathologies which may indicate a hitherto unsuspected embryological origin for early onset cardiac disease in humans.

"Our findings reveal an impressive regenerative capacity of the fetal heart that can compensate for an effective loss of half of the cardiac tissue," concludes Professor Cox. "To the best of our knowledge, this represents the first in vivo demonstration of selection against diseased tissue during embryonic heart development." The work also suggests that some cell populations within the heart are better able to regenerate than others and that those others are likely to be the source of later pathology.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related biology news :

1. Scientists identify embryonic stem cells by appearance alone
2. Embryonic stem cell strategy advanced with UCSF finding
3. Human embryonic stem cells remain embryonic because of epigenetic factors
4. From GM farm animals to embryonic stem cell research
5. Researchers discover important tool in understanding differentiation in human embryonic stem cells
6. Simple recipe turns human skin cells into embryonic stem cell-like cells
7. Oosight microscope enables embryonic stem cell breakthrough
8. Human embryonic stem cell -- derived bone tissue closes massive skull injury
9. Implanting embryonic cardiac cells prevents arrhythmias
10. Widespread support for nonembryonic stem cell research, VCU Life Sciences Survey shows
11. Protein protects embryonic stem cells versatility and self-renewal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... , Feb. 2, 2016   Parabon NanoLabs ... the U.S. Army Research Office and the Defense ... and sensitivity of the company,s Snapshot Kinship ... Mission and, more generally, defense-related DNA forensics.  Although ... capabilities (predicting appearance and ancestry from DNA evidence), ...
(Date:2/1/2016)... 2016 Rising sales of consumer ... touchfree intuitive gesture control market size ... of consumer electronics coupled with new technological advancements to ... size through 2020   --> ... technological advancements to drive global touchfree intuitive gesture control ...
(Date:2/1/2016)...  Wocket® smart wallet ( www.wocketwallet.com ) announces the launch of a ... . Las Vegas , where Joey appeared at ... Las Vegas , where Joey appeared at the Wocket booth ... ad was filmed at the Consumer Electronics Show (CES2016) in ... meet and greet fans. --> --> ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... 4, 2016  CytoSorbents Corporation (NASDAQ: CTSO ... flagship CytoSorb® blood filter to treat deadly inflammation ... world, announced that CEO Dr. Phillip Chan ... Capital Group,s 2016 Disruptive Growth & Healthcare Conference, ... Conference Presentation Details: Where: Convene ...
(Date:2/4/2016)... 2016 ContraVir Pharmaceuticals, Inc. (NASDAQ: CTRV ... commercialization of targeted antiviral therapies, announced today that it ... to be held February 8-9, 2016, at the Waldorf ... Growth & Healthcare Conference, taking place in ... James Sapirstein , Chief Executive Officer of ContraVir, ...
(Date:2/4/2016)... ... February 04, 2016 , ... ... leading supplier of Semantic Graph Database technology has been recognized As “ Best ... by Corporate America Magazine. , “At Corporate America, it’s our priority to showcase ...
(Date:2/3/2016)... 2016   ViaCyte, Inc ., a leading, ... stem cell-derived islet replacement therapy for the treatment ... announced that ViaCyte and Janssen Biotech, Inc., one ... Johnson, have agreed to consolidate the assets of ... provides ViaCyte with an exclusive license to all ...
Breaking Biology Technology: