Navigation Links
Embryonic development protein active in cancer growth
Date:3/6/2012

normal cells. They identified that such antibodies could target ROR1, accounting for the specificity of these antibodies in reacting with cancer cells. They identified another protein that could interact with ROR1 to stimulate the growth and/or survival of leukemia cells and that antibodies generated against ROR1 could block this function.

The discovery that ROR1 functions similarly in breast cancer heightens hopes. When the protein was silenced in human breast cancer cells, the cancer cells had slower rates of growth in the laboratory and in animal studies.

"There was a qualitative difference," said Kipps. "When ROR1 was knocked down, it took away some of the growth advantage enjoyed by cancer cells. Their capacity to survive also was impaired. This could affect the capacity of the cancer cells to survive treatment with other anti-cancer agents or generate tumors altogether."

The researchers report that expression levels of ROR1 correlate with the severity of at least some forms of breast cancer. The most aggressive cancers were the ones more likely to express ROR1. "That suggests ROR1 could be a good target for treating the most aggressive kinds of breast cancer, particularly the ones that lack expression of hormone receptors or the marker HER2/neu, which already can be targeted by monoclonal antibodies," Kipps said.

The discovery of ROR1's role in both blood and breast cancers also suggests it might have a similar function in other forms of cancer, a possibility Kipps said researchers will pursue.


'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related biology news :

1. U-M human embryonic stem cell line placed on national registry
2. Metabolic defects in mice corrected with transplanted embryonic neurons
3. New roles emerge for non-coding RNAs in directing embryonic development
4. UCLA scientists complete first mapping of molecule found in human embryonic stem cells
5. Gladstone scientists identify genes involved in embryonic heart development
6. Improvements in embryonic preimplantation genetic screening techniques
7. Repulsion more important than cohesion in embryonic tissue separation
8. States now fund majority of human embryonic stem cell research
9. Research!America asks Congress to support embryonic stem cell research now
10. Congressman, CSHL president urge quick action to reverse judicial embryonic stem cell research ban
11. Ronin recruits protein allies to sustain embryonic stem cell growth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Embryonic development protein active in cancer growth
(Date:7/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ) has ... Market by Application, Technology, Function & Geography - Global ... The next generation biometrics market is expected to ... 17.9% between 2015 and 2020 Travel & ... Safran SA ( France ), NEC ...
(Date:6/30/2015)... -- Genisphere announced Tom Bliss ... develop Genisphere,s therapeutics capabilities and portfolio. Mr. Bliss comes ... of the last 25 years in leadership positions at ... & Johnson. Tom started his career in Investment Banking, ... He graduated from Dartmouth College with a BA in ...
(Date:6/25/2015)... 2015 According to a ... & Area), Technology, Material (Optical Prism, Piezoelectric, Capacitive ... & Others) & Geography - Global Forecast to ... market is expected to reach $14,500.07 Million by ... Browse 76 market Tables and 109 Figures ...
Breaking Biology News(10 mins):Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4
... from bed-ridden patients to elite athletes, a team of American ... "switch" that allows mutations or light signals to be turned ... a living mammal. For humans, this work could lead to ... new muscle cells to replace those that are damaged, worn ...
... CRUZ, CA--A Cancer Genomics Browser developed by researchers at ... way to visualize and analyze data from studies aimed ... roots of the disease. The browser consists ... researchers find patterns in the huge amounts of clinical ...
... damage can be triggered by various insults, including hepatitis ... can lead to cancer. A new study by researchers ... reveals how one protein helps decide the fate of ... online on March 30th in the Journal of ...
Cached Biology News:Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle 2Cancer Genomics Browser gives cancer researchers a powerful new tool 2Cancer Genomics Browser gives cancer researchers a powerful new tool 3Cancer Genomics Browser gives cancer researchers a powerful new tool 4
(Date:7/29/2015)... /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ) today announced ... Officer has resigned.  The Company has hired Andrew ... in December 2014, as full time interim CFO and ... Andy Ashworth began his employment today, ... transition.  Andy was the Company,s CFO from September 2011 ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... ... solutions, today announced its GHS Label Guide . To align chemical container ... (GHS), this guide includes explanations of label components, an example of an accurate ...
(Date:7/29/2015)... ... ... The third Medical Innovation Impact Index (MI3) Alert considers FDA processes for ... current system received a score of 0 (range -10 to +10) for its impact ... Fairleigh Dickinson University’s ( FDU ) Rothman Institute of Innovation and Entrepreneurship. Several changes ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... ... Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel, a nighttime-specific product that targets ... amount of sugars that are able to enter fat cells, inhibiting the formation ...
Breaking Biology Technology:BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3Brady Announces a New GHS Label Guide 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 3Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 2Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 3
... Preclinical Research at Upcoming Conferences, CALGARY, Sept. ... ONCY) today announced the participation of five of ... conferences,through November 15, 2008 covering clinical trial results ... time for Oncolytics as we begin to share ...
... Surgeons with No-Touch,Surgical Tool For Precision Brain ... 22 OmniGuide, Inc., announced,today the introduction ... flexible,CO2 laser scalpel for neurosurgery. The BeamPath ... microsurgical tool for various central,nervous system (CNS) ...
... their health, yet up to ... elevated risk for cardiovascular events, yet 20 percent, of those have not spoken ... ... A new survey of men and,women age 40 and older in the United ...
Cached Biology Technology:Oncolytics Biotech Inc. Collaborators to Present REOLYSIN(R) Clinical Trial 2Oncolytics Biotech Inc. Collaborators to Present REOLYSIN(R) Clinical Trial 3OmniGuide Introduces The BeamPath Neuro(TM): A CO2 Laser Fiber for Brain And Spine Surgery 2OmniGuide Introduces The BeamPath Neuro(TM): A CO2 Laser Fiber for Brain And Spine Surgery 3Risky Business: New Survey Suggests Many Americans Live Dangerously, Even When They Say They Aren't 'Risk Takers' 2Risky Business: New Survey Suggests Many Americans Live Dangerously, Even When They Say They Aren't 'Risk Takers' 3Risky Business: New Survey Suggests Many Americans Live Dangerously, Even When They Say They Aren't 'Risk Takers' 4Risky Business: New Survey Suggests Many Americans Live Dangerously, Even When They Say They Aren't 'Risk Takers' 5Risky Business: New Survey Suggests Many Americans Live Dangerously, Even When They Say They Aren't 'Risk Takers' 6Risky Business: New Survey Suggests Many Americans Live Dangerously, Even When They Say They Aren't 'Risk Takers' 7
... BMH 71-18 mutS and ES1301 mutS are ... Use of these strains prevents repair of ... to high mutation efficiencies and making them ... and Altered Sites II Mutagenesis Systems. Both ...
1 unit is sufficient for 1 caspase activity assay....
RABBIT ANTI WARFARIN...
Request Info...
Biology Products: