Navigation Links
Embryology study offers clues to birth defects
Date:6/9/2009

LA JOLLA, Calif., June 9, 2009 -- Gregg Duester, Ph.D., professor of developmental biology at Burnham Institute for Medical Research (Burnham), along with Xianling Zhao, Ph.D., and colleagues, have clarified the role that retinoic acid plays in limb development. The study showed that retinoic acid controls the development (or budding) of forelimbs, but not hindlimbs, and that retinoic acid is not responsible for patterning (or differentiation of the parts) of limbs. This research corrects longstanding misconceptions about limb development and provides new insights into congenital limb defects. The study was published online in the journal Current Biology on May 21.

In studies of mice and zebrafish, the team found that retinoic acid suppresses the gene fibroblast growth factor 8 (Fgf8) during the period when forelimb budding occurs, creating a suitable environment for the creation of forelimb buds.

"For decades, it was thought that retinoic acid controlled limb patterning, such as defining the thumb as being different from the little finger," said Dr. Duester. "However, we have demonstrated in mice that retinoic acid is not required for limb patterning, but rather is necessary to initiate the limb budding process. We also found that retinoic acid was unnecessary for hindlimb (leg) budding, but was needed for forelimb (arm) budding."

Congenital birth defects of the arms, legs, hands or feet result from improper development of limb bud tissues during embryogenesis. These processes are regulated by signaling molecules that control the growth and differentiation of progenitor cells by regulating specific genes. One of these signaling molecules is retinoic acid, a metabolite produced from vitamin A (retinol), which plays a key role in the development of limbs and other organs. Dr. Duester's lab was instrumental in identifying Raldh2 and Raldh3, the genes responsible for retinoic acid synthesis, and has shown that retinoic acid
'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Colon cancer screening technique shows continued promise in new study
2. Study finds colorectal cancer rates increasing worldwide
3. MU study finds connection between evolution, classroom learning
4. Study: Illegal fishing harming present and future New England groundfish fisheries
5. Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine
6. Simple drug treatment may prevent nicotine-induced SIDS: Study
7. Tulane receives grant to study limb regeneration
8. CU-Boulder study shows 53 million-year-old high Arctic mammals wintered in darkness
9. New study finds lowfat chocolate milk is effective post-exercise recovery aid for soccer players
10. International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury
11. IFAR contributes to study that finds genes that influence the start of menstruation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Wis. No matter how many times it,s ... social, communicating creatures. , But by using ... organisms radically alter their behavior to suit their ... of them are present, and act accordingly. , ... millions, it may change from innocuous to pathogenic, ...
(Date:9/18/2014)... manipulate spoken language is unique to humans. "The genetic ... of human evolution to make this possible are largely ... now have," says Wolfgang Enard, Professor of Anthropology and ... the molecular biological basis of language Enard has now ... latest study, undertaken in collaboration with scientists at several ...
(Date:9/18/2014)... researchers and their colleagues have built the first ... academic performance and behavioral trends. In other words, ... even if you don,t -- and how that ... students, happiness, stress, depression and loneliness to their ... general population for example, to monitor mental ...
Breaking Biology News(10 mins):Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4
... A Webinar hosted by TorreyPines Therapeutics, Inc. (NASDAQ: ... bring together industry experts to discuss the opportunity ... the inhibition of the neurotransmitter glutamate. The company,s ... moderate a discussion following brief presentations by: ...
... (June 20, 2008) The future of high-intensity x-ray ... U.S. Department of Energy,s Argonne National Laboratory have devised ... "The free electron laser oscillator (X-FELO) we are proposing ... brighter than currently operating machines," Argonne Distinguished fellow Kwang-Je ...
... knowfor sure. Adding to a growing literature ,on ... ,function, it is now shown that one lactate dehydrogenase family ... ,work on this glycolytic enzyme had shown that it is ... ,only speculative. In an article on p. 26 Odet et ...
Cached Biology News:Treating chronic pain, migraine & muscle spasticity through inhibition of neurotransmitter glutamate 2Treating chronic pain, migraine & muscle spasticity through inhibition of neurotransmitter glutamate 3A novel X-ray source could be brightest in the world 2July 2008 highlights 2
(Date:9/19/2014)... DUBLIN , September 19, 2014 ... Research and Markets ( http://www.researchandmarkets.com/research/b2jxhs/micro_market ) has announced the ... Pre-packed Chromatography Columns"  report to their offering.  ... columns market is one of the fastest-growing segments ... at $1.2 billion in 2013, and expected to ...
(Date:9/18/2014)... 2014 HealthTronics, Inc ., ... radiology products and services, announced that a poster ... cryoablation) versus external beam radiotherapy (EBRT) is being ... Urological Association (MAAUA) Annual Meeting in Baltimore, Maryland ... of Cryosurgery and External Beam Radiation as Treatments ...
(Date:9/18/2014)... Mich. , Sept. 18, 2014  Health Enhancement Products, ... firm investigating early-stage algae bioactive compounds and metabolic processes, is ... the company,s board of directors. Ms. Nola E. Masterson ... investment advisor joined the board effective September 17, 2014. ... Masterson agree to join our board," states Andrew Dahl ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... "Global and Chinese Stem Cell Industry Report, 2014-2017" ... cells are undifferentiated biological cells that can differentiate into ... more stem cells. Stem cell therapy can be applied ... hematological system disease), nervous system diseases, damage or lesion ...
Breaking Biology Technology:Micro Market Monitor : Global Pre-packed Chromatography Columns 2HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3
... Getty Images The Olympics of Biotech , ,The ... year. Though this is still a primarily American-influenced event, it ... the industry becomes part of the economies of many countries. ... two weeks, the biotech Olympics run about four days every ...
... the market began its downward trend three years ago ... the financial strain. However, as the price of computers ... the need for IT services grew. Many IT staffers ... their IT staff before, and looked to begin working ...
... - A free online collection of multimedia resources on children's ... books and authors has launched on a Wisconsin ... the school year. , , TeachingBooks is a new ... journal and newspaper articles, encyclopedias and other resources to Wisconsin ...
Cached Biology Technology:The Olympics: A Biotech Perspective 2The Olympics: A Biotech Perspective 3Expetec expands IT staff services in Wisconsin 2Expetec expands IT staff services in Wisconsin 3TeachingBooks brings free K-12 resources to Wisconsin residents 2
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
MW5...
Mouse GM CSF Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
... the membrane-permeant ester forms (CCF2-AM and ... beta-lactamase substrates, CCF2 and CCF4. These ... where cleavage by endogeneous cytoplasmic esterases ... charged forms, thereby trapping them in ...
Biology Products: