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Embryo biopsy does not affect early growth and risk of congenital malformations in PGD/PGS babies
Date:7/8/2008

ificantly different to the other two groups.

The PGD/PGS children did have a lower body mass index (BMI) at age two than did the SC children. Prof Bonduelle said the reason for this might have something to do with the babies' diet: "We found that mothers who conceived after PGD/PGS worked less (working 63% of the time) than the ICSI mothers (working 77% of the time) and SC mothers (working 83% of the time); PGD/PGS children were less frequently in day care centres. We speculate that different, more healthy food might have been given to PGD/PGS children by the parents, given the finding that their mothers stayed at home more frequently, and this may be the reason for the healthier BMI."

"Complications of pregnancy and older parental age were more present in the PGD/PGS and ICSI groups, but these are both factors that are known to be present more frequently in mothers after assisted reproduction technology," said Prof Bonduelle. "Mothers and fathers of SC babies were significantly younger at delivery compared to the other two groups, and this also contributes to fewer pregnancy complications."

Other work published this year by the same research group has shown that there was no difference between the PGD/PGS, ICSI and SC children in other developmental areas, such as motor, mental, and socio-emotional development and language. Nor did the parents differ in terms of parental stress and health.

The researchers are continuing their study of PGD/PGS children as, so far, there are insufficient numbers to draw firm conclusions about any differences in major malformation rates. Two PGD/PGS children, one ICSI child and two SC children had major malformations. In the PGD/PGS group, one child suffered from a ventricular septum defect (a heart problem) and another child had hemivertebrae with gibbus (a malformation of the vertebrae causing a hump). One child from the ICSI group born at 39 weeks underwent surgery for an inguinal hernia (a herni
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Contact: Emma Mason
wordmason@mac.com
34-932-308-810
European Society for Human Reproduction and Embryology
Source:Eurekalert

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