Navigation Links
Elevated nitric oxide in blood is key to high altitude function for Tibetans
Date:10/30/2007

formation from 50 near sea-level dwellers from the United States who participated in the study at the General Clinical Research Center at the Cleveland Clinic.

The combined increase in NO and blood flow levels resulted in double the amount of oxygen delivered to the capillary beds in the Tibetans arms.

The researchers hypothesize that Tibetans have a genetic mutation that allows high NO production. Genetic studies and comparable data on sea-level populations living at high altitude would be needed to test that hypothesis, said Beall.

During the study, the researchers also recognized another population difference: Tibetan women were found to have higher nitrite and lower nitrate levels than those of Tibetan men, whereas no gender differences were found in sea-level dwellers.

In this research, blood flow is determined by the length, number and width of the diameter of blood vessels. These numbers are determined partly by NO, which is a dilator of the vessels and prevents high blood pressure, which would result from increased blood flow in restricted blood vessels. NO also helps in the release of oxygen to tissues. NO reacts in the blood to produce nitrite, nitrate, nitrosothiol proteins and -nitrosyl hemoglobin, which can be used as indicators of NO production. To confirm the increases in NO, the researchers subjected the Tibetan samples to sensitive high performance liquid chromatography, where the results verified the 10-fold increase of NO in the blood.

This study continues to unravel the mysteries of high altitude adaption and follows Bealls 2001 study, published in Nature, on the NO levels in exhaled breath of Tibetans, which were found to be 25 percent greater than that of local Cleveland residents. There was also a related paper on NO and pulmonary blood flow in 2005 in the Journal of Applied Physiology. Brian Hoit of the department of medicine at the Case Western Reserve School of Medicine was the lead author on that paper.


'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Elevated temperature enhances success of viral cancer therapy
2. Males with elevated levels of testosterone lead shorter lives but have more success siring offspring
3. UCSD study reveals how plants respond to elevated carbon dioxide
4. Study links high levels of nitric oxide to infertility and sperm DNA damage
5. Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
6. Deep sea algae connect ancient climate, carbon dioxide and vegetation
7. High carbon dioxide levels spur Southern pines to grow more needles
8. Field tested: Grasslands wont help buffer climate change as carbon dioxide levels rise
9. Higher carbon dioxide, lack of nitrogen limit plant growth
10. Report warns about carbon dioxide threats to marine life
11. Increase in carbon dioxide emissions accelerating
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Territories in Canada and have sent smoke drifting down ... NASA,s Aqua satellite collected this natural-color image with ... 26, 2014. Actively burning areas, detected by MODIS,s thermal ... are drifting northward in this image. Smoke is ... has caused power outages in the area and because ...
(Date:7/29/2014)... from scientists at the University of Kent has shown ... are regulated a breakthrough that could have a ... from Kent,s School of Biosciences uncovered the mechanism whereby ... known as actin filaments are ,fine-tuned, to ... filaments appear to completely stable, providing a framework for ...
(Date:7/29/2014)... that brings together two of the major disciplines behind ... insect fossils through stunning photographs and unique illustrations. , ... Jepson, details the incredible preservation and diversity of fossilised ... what these remarkable fossils can tell us about the ... our planet. Like the mosquito in Jurassic Park, many ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2
... The naked mole rat, a curiously strange, hairless rodent, ... Scientists at The University of Texas Health Science Center San ... explore this mystery. On May 2 a Barshop Institute ... protein disposal called proteasome assemblies differ in composition ...
... UPTON, NY Hydrogen gas offers one of ... fuels. But traditional methods of producing pure hydrogen face ... releasing harmful carbon dioxide into the atmosphere or requiring ... Now, scientists at the U.S. Department of Energy,s (DOE) ...
... announced today that it is a Grand Challenges Explorations winner, ... Dr. Gregor Reid and his team are the first ... The research project will study the impact of ... on the health outcomes of pregnant women and their children. ...
Cached Biology News:Scientists find differences in naked mole rat's protein disposers 2Low-cost nanosheet catalyst discovered to split hydrogen from water 2Low-cost nanosheet catalyst discovered to split hydrogen from water 3Low-cost nanosheet catalyst discovered to split hydrogen from water 4Lawson recieves Grand Challenges Explorations grant for groundbreaking research 2
(Date:7/30/2014)... 2014 Adding to their already extensive ... special – Buy 2 of any Weighing Boats ... benefit lab technicians looking for durable and reliable weighing ... for multiple applications including weighing liquids, solid, or granulated ... including diamond-shaped, hexagonal, square, aluminum weighing, and standard boats. ...
(Date:7/29/2014)... have hurdled a number of significant technological challenges ... observing technology originally created for the James Webb ... Investigator Harvey Moseley, a scientist at NASA,s Goddard ... that electrostatically actuated microshutter arrays that is, ... are as functional as the current technology,s magnetically ...
(Date:7/29/2014)... Tough, ultralight foam of atom-thick sheets can be made ... invented at Rice University. , In microscopic images, ... with floors and walls that reinforce each other. The ... and walls of graphene oxide that self-assemble with the ... researchers say the foam could find use in structural ...
(Date:7/29/2014)... According to the new research report  "Digital ... Software), Delivery Modes (Web Based/Cloud Based) & Whole Slide ... published by MarketsandMarkets, analyzes and studies the major market ... North America , Europe , ... the World (RoW). Browse 78 market data ...
Breaking Biology Technology:Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Tough foam from tiny sheets 2Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3
... In a recent report that probably went unnoticed outside ... Managers released figures that show why the rest ... a hotbed for scientific research. The numbers demonstrate that ... in labs; it's about creating jobs for the 21st ...
... Madison, Wis. - CytoDyn , a New ... Bio-Manufacturing facility to manufacture its DNA-based, pre-flu vaccine. ... Waisman Center , the biomanufacturing facility is designed ... and II human clinical trials. CytoDyn hopes to have ...
... Area Technical College would like to see more women going ... of women in IT careers has declined from a high of ... MATC. And at MATC, enrollment of women in IT programs has ... in IT Expo at the college on Wednesday was Patricia ...
Cached Biology Technology:Tapping hidden assets: Wisconsin researchers who can create jobs 2Tapping hidden assets: Wisconsin researchers who can create jobs 3Tapping hidden assets: Wisconsin researchers who can create jobs 4MATC seeks to turn around falling tech enrollment among women 2
96 Well Plate Sterile, RE bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
... Console Orbital Shakers combine high durability ... programming power. The patented triple-counterbalanced ... unit to run with heavy out-of-balance ... system reduces contamination. The heavy ...
... orbital shakers combine high durability and capacity ... triple-counterbalanced heavy-duty mechanism prevents vibration, allowing the ... loads. Every other part, from the large ... thick machined aluminum platform is designed to ...
Biology Products: