Navigation Links
Elevated nitric oxide in blood is key to high altitude function for Tibetans
Date:10/30/2007

CLEVELANDHow can some people live at high altitudes and thrive while others struggle to obtain enough oxygen to function?

The answer for Tibetans who live at altitudes around 14,000 feet is increased nitric oxide (NO) levels. High levels of NO circulate in various forms in the blood and produce the physiological mechanisms that cause the increased blood flow that maintains oxygen delivery despite hypoxialow levels of oxygen in the ambient air and the bloodstream. Researchers from Case Western Reserve University and the Cleveland Clinic report that Tibetans have 10 times more NO and have more than double the forearm blood flow of low-altitude dwellers. The findings from a comparison of NO levels in the high and low altitude dwellers are reported in the article, Higher Blood Flow and Circulating NO Products Offset High-altitude Hypoxia among Tibetans, in the current Proceedings of the National Academy of Sciences (PNAS).

The low barometric pressure of high altitudes generally causes low arterial oxygen content among Tibetans, yet the researchers have found that Tibetans consume oxygen at normal rates.

We asked how that could be done, said Cynthia Beall, the S. Idell Pyle Professor of Anthropology at Case Western Reserve University. For two decades, Beall has been one of the worlds leading researchers in the studies of high altitude adaptation in different populations in Ethiopia, South America and Tibet.

Beall collected blood samples and blood flow readings from the forearms of 88 Tibetans during a 2002 research trip that was funded by the National Science Foundation. The blood flow data and blood samples were brought back to the United States where Serpil Erzurum, chair of pathobiology, Cleveland Clinic, and the papers lead author, analyzed the information. In Erzurums lab, Allison Janocha, a Case Western Reserve graduate, performed many of the technically challenging analyses.

For comparison, the scientists collected the same in
'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Elevated temperature enhances success of viral cancer therapy
2. Males with elevated levels of testosterone lead shorter lives but have more success siring offspring
3. UCSD study reveals how plants respond to elevated carbon dioxide
4. Study links high levels of nitric oxide to infertility and sperm DNA damage
5. Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
6. Deep sea algae connect ancient climate, carbon dioxide and vegetation
7. High carbon dioxide levels spur Southern pines to grow more needles
8. Field tested: Grasslands wont help buffer climate change as carbon dioxide levels rise
9. Higher carbon dioxide, lack of nitrogen limit plant growth
10. Report warns about carbon dioxide threats to marine life
11. Increase in carbon dioxide emissions accelerating
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... YORK, NY (July 24, 2014) Scientists at ... Institute are one step closer to creating a ... a patient,s own cells. , For the ... (iPS) cells lines from skin samples of patients ... developed an accelerated protocol to induce these stem ...
(Date:7/24/2014)... 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced ... control Phase 3 study of Zerenex (ferric citrate), the ... treatment of hyperphosphatemia in patients with end-stage renal disease ... iRon delivery with FErric CiTrate in EsrD) was published ... Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... YORK, NY (July 24, 2014) Scientists at ... Institute are one step closer to creating a ... a patient,s own cells. , For the ... (iPS) cells lines from skin samples of patients ... developed an accelerated protocol to induce these stem ...
Breaking Biology News(10 mins):NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4NYSCF scientists 1 step closer to cell therapy for multiple sclerosis patients 2
... Institutes of Health announced today that it will fund ... -- chemical modifications to genes that result from diet, ... to specific human diseases and biological processes. ... as part of the NIH Roadmap for Medical Research,s ...
... University is being honored for one of its programs ... institute,s intern program has received the roundtable group,s Most ... award, as the best pollution prevention project/program. The honor ... The award is presented based on a program,s ...
... LA JOLLA, Calif., September 15, 2009 -- Researchers ... have discovered that reactive oxygen species, such as ... in forming invadopodia, cellular protrusions implicated in cancer ... professor and director of the Tumor Microenvironment Program ...
Cached Biology News:NIH funds grantees focusing on epigenomics of human health and disease 2NIH funds grantees focusing on epigenomics of human health and disease 3NIH funds grantees focusing on epigenomics of human health and disease 4K-State Pollution Prevention Institute's intern program named best 2Reactive oxygen's role in metastasis 2
(Date:7/25/2014)... 26, 2014 "Ischemic Stroke and ... provides data on the Ischemic Stroke and Cerebral ... information and data relating to the clinical trials ... full global Ischemic Stroke Research Report 2014 at: ... of the trial numbers and their recruitment status ...
(Date:7/25/2014)... 2014 Research and Markets  has ... Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study of ... new experimental technique that is being widely used ... are small molecules that are present in blood, ...
(Date:7/25/2014)... July 25, 2014 Lawrence Livermore scientists ... Thomson Reuters list of " The World's Most Influential ... of the 3,000 researchers who were identified by analyzing ... those who published the highest-impact work (2002-2012 and 2012-2013). ... on combustion modeling . , "This recognition is ...
(Date:7/25/2014)... Sinovac Biotech Ltd. (Nasdaq: SVA ), ... , today announced that it will release its unaudited ... after market close on Thursday, August 14, 2014 EDT. The ... opening on Friday, August 15, 2014, at 8:00 a.m. EDT ... to review the Company,s financial results and provide an update ...
Breaking Biology Technology:Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2
... 2 According to the National Institute of Health, 40 percent ... stage of diabetic retinopathy. Diabetic retinopathy, damage to the retina ... in people with diabetes and is one of the most feared ... patients who,ve had diabetes for 10 years or more will experience ...
... , ... that a new market research report is available in ... Trends , http://www.reportlinker.com/p0164494/Chromium---Global-Market-Trends.html , Worldwide ... while growth in aerospace and industrial gas turbine markets ...
... PLYMOUTH, Mass., Dec. 1 Harvest Technologies Corp. ( ... 60-patient clinical trial conducted at Sri Ramachandra Medical Center ... treat patients with non-reconstructable Critical Limb Ischemia (CLI). Sri ... based in Chennai, India and one of the largest ...
Cached Biology Technology:Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 2Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 3Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 4Reportlinker Adds Chromium - Global Market Trends 2Reportlinker Adds Chromium - Global Market Trends 3Reportlinker Adds Chromium - Global Market Trends 4Reportlinker Adds Chromium - Global Market Trends 5Reportlinker Adds Chromium - Global Market Trends 6Reportlinker Adds Chromium - Global Market Trends 7Reportlinker Adds Chromium - Global Market Trends 8Reportlinker Adds Chromium - Global Market Trends 9Harvest Technologies Announces Trial Results in its India Study Using BMAC to Treat Patients With Non-Reconstructable Critical Limb Ischemia 2Harvest Technologies Announces Trial Results in its India Study Using BMAC to Treat Patients With Non-Reconstructable Critical Limb Ischemia 3
Mouse monoclonal [3576] to Yellow Fever Virus ( Abpromise for all tested applications). Antigen: Tissue / cell preparation...
... 2 Detection System combines the indirect ... principle and Signets unique formulation of ... and reliablility. Signet reagents will achieve ... and automated protocols. ,Signets USA ...
6X Loading Buffer is intended for gel electrophoresis of DNA fragments or PCR products....
Ideally suited for resolving DNA and RNA 10-1000 bases especially PCR products ranging from 100-1000 bp. Gelling temp. (4%) 27C Melting temperature 65C. EEO: 0.10 Rnase/Dnase: none detected...
Biology Products: