Navigation Links
Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
Date:8/21/2013

Amsterdam, NL, 21 August 2013 Metals such as iron, copper, and zinc are important for many biological processes. In recent years, studies have shown that these nutritionally-essential metals are elevated in human Alzheimer's disease (AD) brains and some animal models of AD. Scientists are now exploring whether these metals are causing the neurodegeneration seen in AD or are indicative of other ongoing pathologic processes.

In a new study, investigators used synchrotron x-ray fluorescence microscopy to image metal ions in the brain, focusing on the amyloid plaques that are the hallmark of AD. They found that, in two AD mouse models that exhibit neurodegeneration, the plaques contained about 25% more copper than an AD mouse model that shows little neurodegeneration. Looking at other metals, they found that none of the mouse models had significant increases in iron and very little increases in zinc. Metal content was not related to the age of the plaque. The study is reported in the current issue of Biomedical Spectroscopy and Imaging.

"Since excess copper should not be 'free' in the brain to bind to the plaques, these data suggest that the cellular control of copper is altered in AD, which may lead to toxic reactions between free copper ions and neurons," comments lead investigator Lisa M. Miller, PhD, a biophysical chemist in the Photon Sciences Directorate at Brookhaven National Laboratory. In previous work, Dr. Miller's group found very high levels of copper in human AD plaques.

Since elevated iron in the AD brain is well documented in both human brains and AD mouse models, the researchers measured iron content in the cortex of all three mouse models. They found that iron content was doubled in all AD mouse model cortices compared to controls, whether or not the models showed neurodegeneration. Upon further investigation, spectroscopic data revealed that the excess iron was present in the ferric (oxidized) state and consi
'/>"/>

Contact: Esther Mateike
e.mateike@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Elevated carbon dioxide making arid regions greener
2. Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens
3. Women with HIV shown to have elevated resting energy expenditure
4. Tropical ecosystems regulate variations in Earths carbon dioxide levels
5. Fear factor: Missing brain enzyme leads to abnormal levels of fear in mice, reveals new research
6. Low levels of toxic proteins linked to brain diseases, study suggests
7. Research shows Vitamin D levels drop after pediatric heart surgery, increasing sickness
8. Study shows probiotic Lactobacillus reuteri NCIMB 30242 significantly increased vitamin D levels
9. Exposure to high pollution levels during pregnancy may increase risk of having child with autism
10. Obese male mice father offspring with higher levels of body fat
11. Epigenetic changes mediated by homocysteine levels in plasma may point to schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... July 2, 2014 It is a great ... the appointment of the world-renowned Thoracic and Cardiovascular surgeon, ... Dr. Ginsburg, with over 34 years of ... Hospital and Good Samaritan Regional Medical Center. Dr. Ginsburg ... late 1980,s and is considered an expert in the ...
(Date:7/10/2014)... 2014 Fingerprint Cards, (FPC,s) new mobile ... (DW). A Chinese Top 5 smartphone OEM has selected FPC1021 ... production in October 2014.   FPC is proud ... OEM, which has a planned date for the start of ... for this phone of 3 million units. The Chinese OEM ...
(Date:7/10/2014)... 2014 The widespread adoption of the ... by meaningful use and related federal programs, is ... laboratory information. Now, more than ever, pathologists need ... informatics in order to deliver high quality and ... educational needs of pathologists in this evolving health ...
Breaking Biology News(10 mins):Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2New Clinical Informatics Curriculum Prepares Future Pathologists 2New Clinical Informatics Curriculum Prepares Future Pathologists 3New Clinical Informatics Curriculum Prepares Future Pathologists 4
... the University of Rochester Biomedical Engineering Department has invented ... stem cells. When he captures cancer cells, he ... harvests them for later use in tissue engineering, bone ... and improve health. With Nichola Charles, Jared Kanofsky, ...
... that bacteria that cause diseases like bubonic plague and ... them infectious on or off. , Knowing how disease-causing ... may one day help scientists create drugs that control ... harmless, said Vladimir Svetlov, a study co-author and a ...
... of £23.6M a year to the UK poultry industry but ... against the disease ?one that can be delivered while they ... vaccine virus which provides immunity to IBV has been developed ... vaccine company Intervet UK. It can be delivered to chicks ...
Cached Biology News:Cancer-killing invention also harvests stem cells 2Cancer-killing invention also harvests stem cells 3Cancer-killing invention also harvests stem cells 4Bacteria control how infectious they become, study finds 2Bacteria control how infectious they become, study finds 3In-shell vaccine for chick disease 2
(Date:7/10/2014)... Using microscopic polymer light resonators that expand in ... Quantum Photonics Laboratory have developed new optical sensors ... Optical sensors are ideal for detecting trace gas ... lightweight nature, and immunity to electromagnetic interference. , ... before, the MIT team conceived an extremely sensitive, ...
(Date:7/10/2014)... fractional quantum Hall effect in bilayer graphene and shown ... by an electric field. , The fractional quantum ... thin sheets are exposed to large magnetic fields, is ... individual electrons behave as a single system. However, while ... many details of this collective behavior remain not well ...
(Date:7/10/2014)... out for crude 3-D glasses, polarized glasses, and ... basic devices, used to trick the brain into ... rendered obsolete with the introduction of new holography ... TAU doctoral students Yuval Yifat, Michal Eitan, and ... on nanoantennas that could be used for security ...
(Date:1/15/2014)... approach akin to assembling a club sandwich at ... (NIST) researchers have succeeded in crafting a uniform, ... of foam commonly used in upholstered furniture and ... nanotube-coated polyurethane foam was reduced 35 percent compared ...
Breaking Biology Technology:Swell new sensors 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Layered security: Carbon nanotubes promise improved flame-resistant coating 2
... Mich., Nov. 24 Terumo Heart, Inc. is pleased ... of Chief Executive,Officer (C.E.O.) and President, effective immediately. "With ... strong leadership role in,the future treatment of heart failure. ... the DuraHeart U.S. Pivotal trials in up to 40 ...
... Inc., (OTC Bulletin Board: IMDS) a pioneer in laser,optical ... of its,21st US Patent entitled "Apparatus and Method for ... Spread,Function of the Detected Light," dated November 4, 2008. ... http://www.newscom.com/cgi-bin/prnh/20040412/IMDSLOGO ) , ...
... Boston Scientific,Corporation (NYSE: BSX ) is scheduled to ... held December 2 - 3 in New York City. , ... 30-minute presentation on,Tuesday, December 2, beginning at approximately 8:00 a.m. ... webcast of Mr. Tobin,s remarks will be available to all ...
Cached Biology Technology:Terumo Heart Announces Appointment of William Pinon to Chief Executive Officer and President 2Imaging Diagnostic Systems is Recognized for Its Advanced Engineering in Time-Resolved Techniques by the US Patent Office 2Imaging Diagnostic Systems is Recognized for Its Advanced Engineering in Time-Resolved Techniques by the US Patent Office 3
... Salmonella genomes has allowed the development of ... pairs. The S. enterica Typhimurium (strain LT2) ... bp; 4,440 ORFs) and a plasmid, pSLT ... Sigma-Genosys have been designed to amplify all ...
... The Bio-Stack Twister II Microplate ... top automation solution for integrating BioTeks ... together with expandable microplate capacity, ultimate ... Whether you are adding capacity to ...
XPLAC (S-17)...
Request Info...
Biology Products: