Navigation Links
Elephant shark genome provides new insights into bone formation and adaptive immunity in humans
Date:1/9/2014

1. Singapore, Jan, 09, 2014 - Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) led an international team of researchers that sequenced and analysed the genome of the elephant shark. A comparison of the elephant shark genome with human and other vertebrate genomes revealed why the skeleton of sharks consists entirely of cartilage instead of bones. The findings carry potential implications for human bone disease treatment. The analysis also sheds new light on the origin of the adaptive immune system. The findings of this study are published in the 9 January, 2014 issue of the prestigious scientific journal, Nature.

2. The collaboration with 12 international institutions was headed by IMCB's Prof Byrappa Venkatesh, who is also a chairperson of the "Genome10K" Project. The project was largely funded by the National Institutes of Health (NIH), USA, the world's foremost centre for the support of biomedical research.

Analysis of the elephant shark genome

3. Elephant shark is a member of cartilaginous fishes, which are the oldest living group of jawed vertebrates that diverged from bony vertebrates about 450 million years ago. Cartilaginous fishes include sharks, rays, skates and chimaeras. Unlike humans and other bony vertebrates, cartilaginous fishes are unable to replace cartilage with bone. Among over 1,200 species of cartilaginous fishes, the elephant shark was sequenced due to its compact genome size. Analysis of the elephant shark genome identified a family of genes absent in elephant shark but present in all bony vertebrates. A significant reduction in bone formation was observed when a member of this gene family was knocked out in zebrafish, thereby indicating the importance of this gene family in bone formation. The finding has important implications towards our understanding of bone-related diseases such as osteoporosis and hence the development of effective therapeutic strategies for them.


'/>"/>
Contact: Tan Yun Yun
tan_yun_yun@a-star.edu.sg
656-826-6273
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. MU researchers study of African forest elephants helps guide research efforts in the US
2. Researchers unmask centuries-old elephant imposter
3. Crop-raiding elephants flee tiger growls
4. Study documents decimation of critically endangered forest elephant
5. Elephants are vanishing from DRCs best-run reserve
6. 11,000 elephants slaughtered in national park
7. Low rainfall and extreme temperatures double risk of baby elephant deaths
8. Relocating elephants fails to decrease human-wildlife conflict
9. Violence in Mali threatening survival of endangered elephants
10. Conservationists to create blueprint for saving Malaysias elephants
11. Southern elephant seals likely detect prey bioluminescence for foraging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (NASDAQ: NXTD and NXTDW) a biometric authentication company focused ... the Wocket™ smart wallet at CES 2015 in Las Vegas ... of the "11 Hot Products at CES" in a review published in ... by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
(Date:1/22/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ... "Global Wearable Technologies Market and Applications, Opportunities, Industry ... Forecast 2014-2020" report to their offering. ... that can be worn on the user,s body ...
(Date:12/22/2014)... 2014  NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... the growing mobile commerce market, announces it has retained famous ... the 2015 International CES debut of the Wocket™ biometric smart ... at the NXT-ID booth January 6th and 7 th , ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... introducing expression of a special green-algae gene into ... researchers have been able to elicit specific behavioral ... The work paves the way for better understanding ... with muscles, to regulate behavior in intact, living ...
... the film classic "Flowers for Algernon," but adds a happy ... drugs, to reverse the attention deficits linked to the leading ... of Current Biology reports the findings, which were studied in ... , The results proved so hopeful, that the ...
... A team of scientists led by Priscilla Cooper, a ... the Department of Energy's Lawrence Berkeley National Laboratory, has ... repair (TCR), an essential but still mysterious mechanism of ... information from a cell's DNA is being transcribed into ...
Cached Biology News:Algal protein in worm neurons allows remote control of behavior by light 2Recreating 'Flowers for Algernon' with a happy ending 2Recreating 'Flowers for Algernon' with a happy ending 3Discovering the first steps in transcription-coupled repair 2Discovering the first steps in transcription-coupled repair 3Discovering the first steps in transcription-coupled repair 4Discovering the first steps in transcription-coupled repair 5Discovering the first steps in transcription-coupled repair 6
(Date:1/23/2015)... MD (PRWEB) January 23, 2015 Portal ... modern digital workplaces on Microsoft Office 365 and SharePoint ... Future 50 Award program for being one of the region’s ... revenue and employee growth. , “To be recognized a ...
(Date:1/22/2015)... Jan. 22, 2015  Transwestern | RBJ today announces the firm ... space for Shire a leading biopharmaceutical company, at Two Ledgemont ... RBJ,s Robert Richards , president, and Brian Cohen ... the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Pipette.com has ... to their comprehensive portfolio of Eppendorf products. , ... to purchase a Centrifuge 5424/5424 R and receive the ... either Eppendorf Research plus or Eppendorf Reference 2 ...
(Date:1/22/2015)... January 22, 2015 Diagenode, Inc., ... as the Bioruptor® and complete solutions for epigenetics ... chromatin immunoprecipitation, alleviating the need for manual processing. ... needed for ChIP of histones or transcription factors ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2
... /PRNewswire-FirstCall/ - OncoGenex,Pharmaceuticals (NASDAQ: OGXI ) announced ... Fast Track designation from the U.S. Food & ... prostate cancer. OGX-011 is currently completing five Phase ... and is designed to,inhibit the production of a ...
... 21 /PRNewswire-FirstCall/ - Resverlogix Corp.,("Resverlogix") (TSX:RVX) is pleased ... on August 25, 2008 at 11:00 am MDT ... the presentation there will be a live,question and ... at the following link:, http://services.choruscall.com/links/resverlogix080825.html , ...
... BPUR ) today announced its financial results for the ... the company reported a net,loss of $4.6 million, or ... $6.4 million, or $0.41 per common share, for the ... July 31, 2008 and 2007 were,37,340,051 and 15,592,025, respectively., ...
Cached Biology Technology:FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 2FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 3FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 4Resverlogix Notice of Conference Call & Webcast 2Biopure Announces 2008 Third Quarter Financial Results 2Biopure Announces 2008 Third Quarter Financial Results 3Biopure Announces 2008 Third Quarter Financial Results 4Biopure Announces 2008 Third Quarter Financial Results 5Biopure Announces 2008 Third Quarter Financial Results 6Biopure Announces 2008 Third Quarter Financial Results 7
... Fully automated, GLP-compliant Facility , Galaxy LIMS, ... , Highly experienced scientists ,We offer individual ... or full plasmids for single or double ... used when the DNA of interest is ...
Great for biotinylating DNA/RNA probes...
Anti-Wnt-2 Polyclonal Antibody Description: 100 g purified goat polyclonal antibody. Reacts with human/mouse/rat. Tested in Western blot/IP/IHC. Research Focus: signal transduction Storage...
...
Biology Products: