Navigation Links
Elephant shark genome provides new insights into bone formation and adaptive immunity in humans
Date:1/9/2014

1. Singapore, Jan, 09, 2014 - Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) led an international team of researchers that sequenced and analysed the genome of the elephant shark. A comparison of the elephant shark genome with human and other vertebrate genomes revealed why the skeleton of sharks consists entirely of cartilage instead of bones. The findings carry potential implications for human bone disease treatment. The analysis also sheds new light on the origin of the adaptive immune system. The findings of this study are published in the 9 January, 2014 issue of the prestigious scientific journal, Nature.

2. The collaboration with 12 international institutions was headed by IMCB's Prof Byrappa Venkatesh, who is also a chairperson of the "Genome10K" Project. The project was largely funded by the National Institutes of Health (NIH), USA, the world's foremost centre for the support of biomedical research.

Analysis of the elephant shark genome

3. Elephant shark is a member of cartilaginous fishes, which are the oldest living group of jawed vertebrates that diverged from bony vertebrates about 450 million years ago. Cartilaginous fishes include sharks, rays, skates and chimaeras. Unlike humans and other bony vertebrates, cartilaginous fishes are unable to replace cartilage with bone. Among over 1,200 species of cartilaginous fishes, the elephant shark was sequenced due to its compact genome size. Analysis of the elephant shark genome identified a family of genes absent in elephant shark but present in all bony vertebrates. A significant reduction in bone formation was observed when a member of this gene family was knocked out in zebrafish, thereby indicating the importance of this gene family in bone formation. The finding has important implications towards our understanding of bone-related diseases such as osteoporosis and hence the development of effective therapeutic strategies for them.


'/>"/>
Contact: Tan Yun Yun
tan_yun_yun@a-star.edu.sg
656-826-6273
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. MU researchers study of African forest elephants helps guide research efforts in the US
2. Researchers unmask centuries-old elephant imposter
3. Crop-raiding elephants flee tiger growls
4. Study documents decimation of critically endangered forest elephant
5. Elephants are vanishing from DRCs best-run reserve
6. 11,000 elephants slaughtered in national park
7. Low rainfall and extreme temperatures double risk of baby elephant deaths
8. Relocating elephants fails to decrease human-wildlife conflict
9. Violence in Mali threatening survival of endangered elephants
10. Conservationists to create blueprint for saving Malaysias elephants
11. Southern elephant seals likely detect prey bioluminescence for foraging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... NEW YORK , Nov. 18, 2014 /PRNewswire/ ... iris-based identity authentication solutions, and MorphoTrust USA ... solutions and services, today announced a strategic partnership ... across enterprise, motor vehicle administration (MVA), airport screening ... leader in identity-related solutions, MorphoTrust serves consumers through ...
(Date:11/7/2014)... Debra Auguste, associate professor, biomedical engineering, in the ... of New York, have identified a molecule that ... the most aggressive forms of breast cancer. , ... mortality rate owing to aggressive proliferation and metastasis ... Professor Auguste,s team, discovered the overexpression of intercellular ...
(Date:11/6/2014)... for a predator. Except when that predator runs so fast ... to its size, is the fastest creature on Earth. Some ... second (at about five miles per hour). The fastest human ... gold from the tiger beetle, a person would have to ... has a problem. At peak speeds, everything becomes a blur. ...
Breaking Biology News(10 mins):EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3The tiger beetle: Too fast to see 2
... cells that promotes growth appears to spur restoration of ... sclerosis (MS), researchers at Case Western Reserve University School ... until published in the online version of Nature ... on Sunday, May 20. In animals injected with ...
... , , , , ... AUDIO: Plants capable of producing oils for industrial chemicals and human ... Click here for more information. , , ... , , , , , ...
... researchers from UCSF and UC San Diego has identified an ... and animal studies, suggesting it could offer a low-dose, low ... throughout the world. Based on these results, the ... as auranofin, from the U.S. Food and Drug Administration, and ...
Cached Biology News:Growth factor in stem cells may spur recovery from MS 2Supercharged safflower 2Supercharged safflower 3Supercharged safflower 4Lab tests show arthritis drug effective against global parasite 2Lab tests show arthritis drug effective against global parasite 3Lab tests show arthritis drug effective against global parasite 4
(Date:11/24/2014)...  IGI Laboratories, Inc. (NYSE MKT: IG), a ... company, today announced it has submitted an additional abbreviated ... Drug Administration (FDA), which brings the Company,s total number ... submissions now pending at the FDA. ... Company, commented, "Our team here at IGI has continued ...
(Date:11/24/2014)... , Nov. 24, 2014  Last week, ... G.K. Butterfield (D-NC) took a bold bipartisan ... by introducing the OPEN Act. Original co-sponsors of ... (D-FL). The Act will incentivize drug makers and ... rare diseases and pediatric cancers, which opens the ...
(Date:11/24/2014)...   First published articles now ... Elsevier , a world-leading provider of scientific, technical and medical ... of the latest title in the Current Opinion journal ... . Current Opinion in ... to keep up-to-date with the expanding volume of information published ...
(Date:11/24/2014)... USA (PRWEB) November 23, 2014 One of ... field of optics and photonics is now available to high ... very low cost. SPIE, the international society for optics ... to the complete SPIE Digital Library available to ... price. , “Light-based technologies are integral to all areas of ...
Breaking Biology Technology:IGI Laboratories, Inc. Announces ANDA Submission 2OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2Elsevier Announces Launch of New Journal: Current Opinion in Food Science 2Elsevier Announces Launch of New Journal: Current Opinion in Food Science 3SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2
... not your parents' generation of corporate leaders. , ,A ... cross the lips of gray-haired, gray-suited corporate executives. Today, ... Wisconsin doesn't yet have it. , ,At the Olympia ... academic and arts groups met to brainstorm strategies for ...
... Wis. - The 53 Wisconsin companies that won ... Innovation Research (SBIR) and Small Business Technology Transfer (STTR) ... at an upcoming banquet in Madison. , ,The awards ... transfer workshop. The workshop will focus on SBIR/STTR funding ...
... 30 years ago, then-Gov. Pat Lucey and the Wisconsin ... property taxes. It was a bipartisan decision that has ... times and foreign competition threatened. , ,Today, Wisconsin policymakers ... a competitive toehold by reducing state taxes that discourage ...
Cached Biology Technology:Tech leaders call for more creativity 2Modernizing the tax code can make Wisconsin tech businesses more competitive 2Modernizing the tax code can make Wisconsin tech businesses more competitive 3
... stretching or compression of a single cell ... so you can precisely regulate the degree ... 64 unique strain parameters. ST-160 has a ... models are compatible with Nikon, Olympus, Leica, ...
... Glycosylation is a post-translational modification ... biological functions, including immune regulation, inflammation, ... Biotechnology has developed two lectin based ... and Wheat Germ Agglutinin (WGA), that ...
... Pierce offers maleimide activated carrier ... hapten-carrier conjugates. Imject Maleimide Activated Carrier ... have been preactivated with a heterobifunctional ... a stable, sulfhydryl-reactive carrier protein. ...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
Biology Products: