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Einstein scientists receive $10 million NIH grant
Date:2/26/2009

February 26, 2009 - (BRONX, NY) - Four Albert Einstein College of Medicine faculty members were awarded a five-year, $10-million grant from the National Institutes of Health to study autophagya fundamental cell process that may hold the key to aging.

Autophagy (which literally means "self-eating") refers to several surveillance systems that all cells rely on to find, digest, and recycle molecules within them that have become damaged. This cellular recycling both "cleans up" the cell and provides it with energy, since digested products can be used as fuel. Many studies have documented that autophagy becomes less efficient with age, allowing protein and other cellular components to gradually accumulate inside cells and, almost certainly, interfere with normal cell function.

The Einstein consortium is led by Ana Maria Cuervo, M.D., Ph.D., associate professor of developmental & molecular biology, of anatomy & structural biology, and of medicine at Einstein and one of the world's leading experts on autophagy. With the help of the NIH grant, Dr. Cuervo and her colleagues will test their hypothesis that impaired autophagy may explain the decline in organ function, weakened immunity, and other functional losses associated with aging. More specifically, the researchers will:

  • look at the role of two different types of autophagy in liver and brain function as well as immunity, under normal and stressful conditions
  • analyze how these two types of autophagy change as the liver, brain, and immune system age
  • determine how changes in autophagy that occur with age contribute to the aging of the entire organism, to the gradual deterioration of cognitive function, to the failure with age of two essential immune functions (antigen processing and presentation, and T helper cell activation and tolerance), and to abnormalities in lipid metabolism

"These studies will involve the cooperation of all four of us on the Einst
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Contact: Deirdre Branley
sciencenews@aecom.yu.edu
718-430-2923
Albert Einstein College of Medicine
Source:Eurekalert

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