Navigation Links
Einstein scientists receive $10 million NIH grant
Date:2/26/2009

February 26, 2009 - (BRONX, NY) - Four Albert Einstein College of Medicine faculty members were awarded a five-year, $10-million grant from the National Institutes of Health to study autophagya fundamental cell process that may hold the key to aging.

Autophagy (which literally means "self-eating") refers to several surveillance systems that all cells rely on to find, digest, and recycle molecules within them that have become damaged. This cellular recycling both "cleans up" the cell and provides it with energy, since digested products can be used as fuel. Many studies have documented that autophagy becomes less efficient with age, allowing protein and other cellular components to gradually accumulate inside cells and, almost certainly, interfere with normal cell function.

The Einstein consortium is led by Ana Maria Cuervo, M.D., Ph.D., associate professor of developmental & molecular biology, of anatomy & structural biology, and of medicine at Einstein and one of the world's leading experts on autophagy. With the help of the NIH grant, Dr. Cuervo and her colleagues will test their hypothesis that impaired autophagy may explain the decline in organ function, weakened immunity, and other functional losses associated with aging. More specifically, the researchers will:

  • look at the role of two different types of autophagy in liver and brain function as well as immunity, under normal and stressful conditions
  • analyze how these two types of autophagy change as the liver, brain, and immune system age
  • determine how changes in autophagy that occur with age contribute to the aging of the entire organism, to the gradual deterioration of cognitive function, to the failure with age of two essential immune functions (antigen processing and presentation, and T helper cell activation and tolerance), and to abnormalities in lipid metabolism

"These studies will involve the cooperation of all four of us on the Einstein faculty who have jointly received this NIH grant," says Dr. Cuervo. The other three members of the Einstein consortium are Laura Santambrogio, M.D., Ph.D., associate professor of pathology; Fernando Macian-Juan, M.D., Ph.D., assistant professor of pathology; and Mark J. Czaja, M.D., professor of medicine.

"We're hopeful that this research project will lead to fundamental insights that will help us understand, treat or even prevent the metabolic alterations and decline in cognitive and immune function that affect us as we age," says Dr. Cuervo. "Strategies that can keep our cells' autophagic pathways operating efficiently as we get older could help us to enjoy healthier lives well into old age."


'/>"/>

Contact: Deirdre Branley
sciencenews@aecom.yu.edu
718-430-2923
Albert Einstein College of Medicine
Source:Eurekalert

Related biology news :

1. Einstein researchers develop technique to count messages made by single genes
2. Einstein researchers develop a new way to study how breast cancer spreads
3. In scientific first, Einstein researchers correct decline in organ function associated with old age
4. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
5. Einstein researchers receive grants totaling $700,000 for innovative breast cancer research
6. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
7. From stem cells to new organs: Stanford and NYU scientists cross threshold in regenerative medicine
8. 40 minority scientists receive travel fellowships to Experimental Biology 2009 in New Orleans
9. Vanderbilt scientists invent worlds smallest periscopes
10. UCLA stem cells scientists make electrically active motor neurons from iPS cells
11. UCR scientists identify stem-cell genes that help form plant organs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/27/2016)... WEST CHESTER, Ohio , Jan. 27, 2016 /PRNewswire/ ... services supplier based in West Chester, Ohio ... and their award winning service staff, based in ... Track,s technical capacity and ability to provide modifications, installations ... John Dovalina , CEO of PLUS, commented, "PLUS ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the ... pharma and publication industries, will provide the data management ... Centre (NPSC). ... Phenotypic analysis measures ... whole organisms, allowing comparisons between states such as health ...
(Date:1/22/2016)... , Jan. 22, 2016 ... the addition of the "Global Biometrics ... to their offering. --> ... the "Global Biometrics Market in Retail ... --> Research and Markets ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016  NanoViricides, Inc. (NYSE MKT: NNVC) ... CEO, Eugene Seymour , MD, MPH, will present information about ... the Waldorf-Astoria Hotel in New York City . ... be in the Windsor Room at 5:30PM EST. Registered attendees can ... New York City . --> ...
(Date:2/6/2016)... ... ... The Center for Excellence in Education (CEE) will sponsor a Bite of Science ... 2016. This Bite of Science session, hosted by the Smithsonian-Mason School of Conservation, ... in Front Royal, VA from 5:00 p.m. to 8:00 p.m. The dinner is for ...
(Date:2/5/2016)... , Feb. 5, 2016 On Thursday, February ... information source for community, health and disaster services, and ... will integrate to enhance care coordination and service delivery ... services they need and to better connect service providers ... San Diego has handled ...
(Date:2/4/2016)... - New FDA action date of July ... action date of July 22, 2016   --> ... 22, 2016   - Lifitegrast has the ... for the treatment of signs and symptoms of dry eye disease ... to be the only product approved in the U.S. in the past decade indicated for ...
Breaking Biology Technology: