Navigation Links
Einstein scientists receive $10 million NIH grant
Date:2/26/2009

February 26, 2009 - (BRONX, NY) - Four Albert Einstein College of Medicine faculty members were awarded a five-year, $10-million grant from the National Institutes of Health to study autophagya fundamental cell process that may hold the key to aging.

Autophagy (which literally means "self-eating") refers to several surveillance systems that all cells rely on to find, digest, and recycle molecules within them that have become damaged. This cellular recycling both "cleans up" the cell and provides it with energy, since digested products can be used as fuel. Many studies have documented that autophagy becomes less efficient with age, allowing protein and other cellular components to gradually accumulate inside cells and, almost certainly, interfere with normal cell function.

The Einstein consortium is led by Ana Maria Cuervo, M.D., Ph.D., associate professor of developmental & molecular biology, of anatomy & structural biology, and of medicine at Einstein and one of the world's leading experts on autophagy. With the help of the NIH grant, Dr. Cuervo and her colleagues will test their hypothesis that impaired autophagy may explain the decline in organ function, weakened immunity, and other functional losses associated with aging. More specifically, the researchers will:

  • look at the role of two different types of autophagy in liver and brain function as well as immunity, under normal and stressful conditions
  • analyze how these two types of autophagy change as the liver, brain, and immune system age
  • determine how changes in autophagy that occur with age contribute to the aging of the entire organism, to the gradual deterioration of cognitive function, to the failure with age of two essential immune functions (antigen processing and presentation, and T helper cell activation and tolerance), and to abnormalities in lipid metabolism

"These studies will involve the cooperation of all four of us on the Einst
'/>"/>

Contact: Deirdre Branley
sciencenews@aecom.yu.edu
718-430-2923
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Einstein researchers develop technique to count messages made by single genes
2. Einstein researchers develop a new way to study how breast cancer spreads
3. In scientific first, Einstein researchers correct decline in organ function associated with old age
4. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
5. Einstein researchers receive grants totaling $700,000 for innovative breast cancer research
6. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
7. From stem cells to new organs: Stanford and NYU scientists cross threshold in regenerative medicine
8. 40 minority scientists receive travel fellowships to Experimental Biology 2009 in New Orleans
9. Vanderbilt scientists invent worlds smallest periscopes
10. UCLA stem cells scientists make electrically active motor neurons from iPS cells
11. UCR scientists identify stem-cell genes that help form plant organs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... (April 15, 2014) The American Association of Anatomists ... All awards will be presented during the Closing ... Hotel on Tuesday, April 29th at 7:30 p.m. during ... , The 2014 award winners are: , ... PhD, of the Icahn School of Medicine at Mount ...
(Date:4/15/2014)... are many viral diseases in the world for which ... fever, which is spread by mosquitoes in the tropics, ... more familiar in Finland and is easily spread by ... children and the elderly. , Researchers at Aalto University ... in preliminary tests to prevent the spread of one ...
(Date:4/15/2014)... University of Adelaide research into parasites of cuttlefish, ... parasites, astonishing life cycles, and shown how they ... , Researcher Dr Sarah Catalano has described 10 ... in the kidneys of cephalopods (cuttlefish, squid and ... species to be described from Australian waters. ...
Breaking Biology News(10 mins):American Association of Anatomists 2014 award winners 2Nanocrystalline cellulose modified into an efficient viral inhibitor 2Bizarre parasite may provide cuttlefish clues 2
... you know and where you,re positioned on the social ... for food. At least that,s the case with African ... the University of California, Berkeley, who collaborated with researchers ... in Kenya, and at the University of Oxford in ...
... been brought back to life in stunning 3D by ... a paper published in the latest issue of the ... University in Belgium report on the use of a ... to digitally dissect tiny fossils and reveal the preservation ...
... Gene therapy administered intravenously could be an effective ... effects of ionizing radiation in the event of large-scale ... an animal study presented today by University of Pittsburgh ... Society for Therapeutic Radiology and Oncology (ASTRO) in Los ...
Cached Biology News:Social standing influences elephant movement 2Social standing influences elephant movement 3Scientist brings 50 million year old spider 'back to life' 2Intravenous gene therapy protects normal tissue of mice during whole-body radiation 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... ... ... ... by longUrl, so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... tools inspired by video games are revealing how the ... human and animal research. Taking advantage of state-of-the art ... show with new detail how the brain navigates, identifies, ... apply these same technological advances to help people who ...
... by how long it took his computer to boot up, ... cheap and can store enormous quantities of data, but they ... are lost while information is transferred from the hard disk ... of lost productivity and energy consumption runs into the hundreds ...
Cached Biology Technology:Elsevier Sponsors 2010 Semantic Web Challenge 2Elsevier Sponsors 2010 Semantic Web Challenge 3Elsevier Sponsors 2010 Semantic Web Challenge 4Elsevier Sponsors 2010 Semantic Web Challenge 5Elsevier Sponsors 2010 Semantic Web Challenge 6Elsevier Sponsors 2010 Semantic Web Challenge 7Elsevier Sponsors 2010 Semantic Web Challenge 8Elsevier Sponsors 2010 Semantic Web Challenge 9Elsevier Sponsors 2010 Semantic Web Challenge 10Elsevier Sponsors 2010 Semantic Web Challenge 11Virtual reality helps researchers track how brain responds to surroundings 2Racetrack memory 2
... Combining linear motor and ballscrew ... pre-engineered Cartesian solutions that include ... management, and motors., , ... Pass through high-flex cabling for ...
UGT1A6 (D-20)...
... T Squareds patented high efficiency dynamic valve ... With the most compact, lightweight package in ... use in portable air and gas applications., ... high efficiency. , Includes DC Motor. ...
... designed for moving loads quickly and accurately. ... output while limiting overall size. The P5S-P ... ball bearings guided on two rails., ... provide energy absorption and controlled deceleration , ...
Biology Products: