Navigation Links
Einstein researchers receive 2 Grand Challenges Explorations grants to combat HIV and TB

December 4, 2012 (Bronx, NY) Scientists at Albert Einstein College of Medicine of Yeshiva University have been awarded two Grand Challenges Explorations (GCE) grants from the Bill & Melinda Gates Foundation for their innovative global health and development research projects. The grant recipients are Arturo Casadevall, M.D., Ph.D., who is working to create a novel vaccine for tuberculosis (TB), and Ekaterina Dadachova, Ph.D., and Joan Berman, Ph.D., for their work on a novel and promising HIV treatment.

Dr. Casadevall, professor and chair of microbiology & immunology and professor of medicine, was named one of the 80 GCE Round 9 winners for his unconventional approach to developing a vaccine for TB. While current TB vaccines are designed to provoke immune cells to attack the bacteria that cause the disease, Dr. Casadevall proposes a different tack harnessing the tremendous potential of antibodies to kill the invaders and prevent the development of the disease. Dr. Dadachova, professor of radiology and of microbiology & immunology, and Dr. Berman, professor of pathology and of microbiology & immunology, received a Phase II GCE grant to study whether radioimmunotherapy (RIT) can kill the HIV virus in latently infected cells. In RIT, radioactive isotopes attached to antibodies selectively target and destroy cells. Since current anti-retroviral therapy drugs cannot reach the brain, they will also investigate whether the RIT approach can destroy HIV in the central nervous system. The project, which builds on Dr. Dadachova's earlier GCE research with Dr. Casadevall, is one of only 15 projects that advanced to the next level. Drs. Dadachova and Berman will work in collaboration with Dr. Casadevall, New York University researchers Susan Zolla-Pazner, Ph.D., and Miroslaw Gorny, M.D., Ph.D., and Alfred Morgenstern, Ph.D., and Frank Bruchertseifer, Ph.D., from the Institute of Transuranium Elements in Karlsruhe, Germany, who supply valuable radioisotopes for the project.

GCE funds researchers worldwide who are taking innovative approaches to some of the world's toughest and persistent global health and development challenges. GCE invests in the early stages of bold ideas that may help to solve the problems confronting people in the developing world every day.

"Investments in innovative global health research are already paying off," said Chris Wilson, director of Global Health Discovery and Translational Sciences at the Bill & Melinda Gates Foundation. "We continue to be impressed by the novelty and innovative spirit of Grand Challenges Explorations projects and are enthusiastic about this exciting research. These investments hold real potential to yield new solutions to improve the health of millions of people in the developing world, and ensure that everyone has the chance to live a healthy productive life."

Dr. Casadevall also holds the Leo and Julia Forchheimer Chair in Microbiology & Immunology and Dr. Dadachova is the Sylvia and Robert S. Olnick Faculty Scholar in Cancer Research.


Contact: Kim Newman
Albert Einstein College of Medicine

Related biology news :

1. Einstein researcher receives $10.8 million grant to study toxic blood reactions caused by hemoglobin
2. Einstein hosts its first stem cell institute symposium
3. Feinstein Institute receives $1 million grant to study impact of World Trade Center attacks on responders
4. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
7. UNH researchers find African farmers need better climate change data to improve farming practices
8. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
9. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
10. Researchers print live cells with a standard inkjet printer
11. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
Post Your Comments:
(Date:11/18/2015)... PHILADELPHIA , Nov. 18, 2015  As new ... in children, doctors and other healthcare providers face challenges ... counsel families and patients. In addition, as more children ... into a patient,s adulthood and old age. ... The Children,s Hospital of Philadelphia (CHOP) . ...
(Date:11/17/2015)... EASTON, Mass. , Nov. 17, 2015 ... a leader in the development and sale of broadly ... the worldwide life sciences industry, today announced it has ... of its $5 million Private Placement (the "Offering"), increasing ... to $4,025,000.  One or more additional closings are expected ...
(Date:11/11/2015)...   MedNet Solutions , an innovative SaaS-based eClinical technology ... pleased to announce that it will be a Sponsor of ... to be held November 17-19 in Hamburg ... of iMedNet , MedNet,s easy-to-use, proven and ... has been able to deliver time and cost savings of ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... Report is a professional and in-depth study on ...      (Logo: ) , ... the industry including definitions, classifications, applications and industry ... for the international markets including development trends, competitive ...
(Date:11/24/2015)... Nov. 24, 2015  Asia-Pacific (APAC) holds the ... (CRO) market. The trend of outsourcing to low-cost ... but higher volume share for the region in ... however, margins in the CRO industry will improve. ... ( ), finds that the market ...
(Date:11/24/2015)... 24, 2015 Cepheid (NASDAQ: CPHD ) ... the following conference, and invited investors to participate via ...      Tuesday, December 1, 2015 at 11.00 a.m. Eastern ...      Tuesday, December 1, 2015 at 11.00 a.m. Eastern ... New York, NY      Tuesday, December 1, ...
(Date:11/24/2015)... , Nov. 24, 2015 /CNW/ - iCo Therapeutics ... today reported financial results for the quarter ended ... expressed in Canadian dollars and presented under International ... United States ," said Andrew Rae ... advancements regarding iCo-008 are not only value enriching ...
Breaking Biology Technology: