Navigation Links
Einstein researchers discover 2 new ways to kill TB
Date:3/21/2010

of TB bacteria grown in Petri dishes as well as in infected mice.

"We were amazed when we knocked out GlgE that we saw this DNA damage response," says Dr. Jacobs. "That's usually a very effective way to kill bacteria, when you start damaging the DNA."

The researchers discovered a second way of killing TB after observing a crucial connection between their novel alpha glucan pathway and a second pathway that also synthesizes alpha glucans.

When the researchers knocked out one of the other enzymes in their novel pathway, the pathway's shutdown didn't kill the bacteria; similarly, inactivating an enzyme called Rv3032 in the second alpha glucan pathway failed to kill the microbes. But inactivating both of those enzymes caused what the researchers term synthetic lethality: two inactivations that separately were nonlethal but together cause bacterial death.

"The bacteria that cause TB need to synthesize alpha glucans," notes Dr. Jacobs. "And from the bacterial point of view, you can't knock out both of these alpha glucan pathways simultaneously or you're dead. So if we were to make drugs against GlgE and Rv3032, the combination would be extremely potent. And since TB bacteria need both of those alpha glucan pathways to live, it's very unlikely that this combination therapy would leave behind surviving bacteria that could develop into resistant strains."

Dr. Jacobs adds that findings from this study could also enhance treatment of diseases caused by other species of mycobacteria. Leprosy, for example, which still occurs in the U.S. and other countries, is caused by a mycobacterium related to TB. Treating leprosy now involves using several different drugs, some of which are also used to treat tuberculosis.


'/>"/>

Contact: Deirdre Branley
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
2. Einstein researchers receive grants totaling $700,000 for innovative breast cancer research
3. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
4. In scientific first, Einstein researchers correct decline in organ function associated with old age
5. Einstein researchers develop a new way to study how breast cancer spreads
6. Einstein researchers develop technique to count messages made by single genes
7. Einstein scientists receive $10 million NIH grant
8. Empire State Stem Cell Board awards $12.7 million to Albert Einstein College of Medicine
9. Einstein and Pitt researchers develop new TB test that will dramatically cut diagnosis time
10. NIH funds research center for womens reproductive health at Einstein
11. Einstein researchers devise a fast and sensitive way to detect ricin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... uses reversible epigenetic processes to regulate its genes, and ... a picture of the genome regulation taking place in ... Genome Biology and illustrates how the truffle ... genes,. The authors say this may shed light on ... Black truffles (Tuber melanosporum), also known as Prigord truffles, ...
(Date:7/30/2014)... American Chemical Society (ACS) announced today that David L. ... ACS Biomaterials Science & Engineering as editor-in-chief. With ... the new journal will feature high-quality research in the ... or naturally derived materials that interact with living or ... it reflects the tremendous growth in the field of ...
(Date:7/30/2014)... The Governing Board of the Entomological Society of America ... for 2014. The election as a Fellow acknowledges outstanding ... following: research, teaching, extension, or administration. The following Fellows ... Annual Meeting -- which will be held November 16-19, ... BOSQUE-PREZ is a professor with the Department of ...
Breaking Biology News(10 mins):How black truffles deal with the jumpers in their genome 2ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor 2Entomological Society of America recognizes 2014 fellows 2Entomological Society of America recognizes 2014 fellows 3Entomological Society of America recognizes 2014 fellows 4Entomological Society of America recognizes 2014 fellows 5Entomological Society of America recognizes 2014 fellows 6Entomological Society of America recognizes 2014 fellows 7Entomological Society of America recognizes 2014 fellows 8Entomological Society of America recognizes 2014 fellows 9Entomological Society of America recognizes 2014 fellows 10Entomological Society of America recognizes 2014 fellows 11Entomological Society of America recognizes 2014 fellows 12Entomological Society of America recognizes 2014 fellows 13Entomological Society of America recognizes 2014 fellows 14Entomological Society of America recognizes 2014 fellows 15Entomological Society of America recognizes 2014 fellows 16Entomological Society of America recognizes 2014 fellows 17
... (memsys) and Nanyang Technological University (NTU) are collaborating to ... contaminated with oil., If successful, the wider application of ... by companies here to produce distilled water for their ... located at Singapore,s Jurong Island, which produce a lot ...
... University of Manchester scientist has revealed the mechanism that ... lead to new treatments for painful and debilitating skin ... Garrod, in the Faculty of Life Sciences, has found ... molecules on other cells, making a very tough, resilient ...
... newest Earth-observing research mission is nearing launch. The Glory ... and tiny atmospheric particles called aerosols affect Earth,s climate. ... measurements needed to address key uncertainties about climate change. ... Air Force Base in California on Feb. 23 at ...
Cached Biology News:memsys-NTU partnership to enhance water desalination technology 2Cell binding discovery brings hope to those with skin and heart problems 2NASA prepares to launch next Earth-observing satellite mission 2NASA prepares to launch next Earth-observing satellite mission 3
(Date:7/30/2014)... (PRWEB) July 30, 2014 ... of leading Immunologists, Principle Investigators, scientists in the ... J Malemud, Professor at Case Western Reserve University ... his keynote address on “The effects of ... production of matrix metalloproteinase-9”. Arya Biragyn, a Senior ...
(Date:7/29/2014)... SoundConnect , an award ... proud to announce the strategic additions of implementation, ... Boston, Charleston and Atlanta offices. SoundConnect’s organizational ... for hosted solutions, collaboration and mobility that improve ... , SoundConnect was founded in 2004, with the ...
(Date:7/29/2014)... NASA technologists have hurdled a number of significant ... already revolutionary observing technology originally created for the ... by Principal Investigator Harvey Moseley, a scientist at ... has demonstrated that electrostatically actuated microshutter arrays ... voltage are as functional as the current ...
(Date:7/29/2014)... July 29, 2014   Sequenom, Inc. (NASDAQ: ... provides innovative genetic analysis solutions, and Mayo Medical ... services in the United States , ... patents and applications. "We have great appreciation ... care, and we welcome the opportunity to partner with ...
Breaking Biology Technology:Unveiling Breakthroughs in Clinical & Cellular Immunology 2Unveiling Breakthroughs in Clinical & Cellular Immunology 3SoundConnect Organization and Culture is Evolving 2Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4
... 5 /PRNewswire-FirstCall/ - Dr. Brad Thompson, President,and CEO of ... call and webcast on Thursday, November 6, 2008 at,11:00 ... clinical trial results,in its U.S. Phase II trial for ... lung. The results are scheduled to be presented November,6, ...
... Corp (OTC Bulletin Board:,VYTC) today announced that it has ... LLC. Pursuant to the terms of the,amicable agreement, Vyta ... Paul H. Metzinger, President and CEO of Vyta Corp,becomes ... LLC. Terms,of the agreement are included in a Form ...
... Misonix, Inc.,(Nasdaq: MSON ), a developer of ... is used for the ablation of cancer and,worldwide ... a new, three,year, exclusive distribution agreement with privately-held ... the distribution of the,SonaStar(TM) Ultrasonic Surgical Aspirator, the ...
Cached Biology Technology:Oncolytics Biotech Inc. Announces U.S. Phase II Sarcoma Clinical Trial Conference Call 2Vyta Corp Acquires 100% Ownership of BIOAGRA, LLC 2Misonix Announces New Distribution Agreement for The Netherlands 2Misonix Announces New Distribution Agreement for The Netherlands 3
Bethyl Laboratories Epitope Retrieval Buffer-Reduced pH will unmask antigenic sites from formaldehyde fixation and allow for subsequent immunostaining. Shelf-Life: 1 year from date of receipt...
Mycoplasma and virus tested...
Mycoplasma and virus tested...
... XP Western Protein Standards are specifically ... molecular weight estimation directly on western ... IgG binding site, allowing direct visualization ... to detect your target protein on ...
Biology Products: