Navigation Links
Einstein researchers discover 2 new ways to kill TB
Date:3/21/2010

March 21, 2010 ─ (BRONX, NY) ─ Researchers at Albert Einstein College of Medicine of Yeshiva University have found two novel ways of killing the bacteria that cause tuberculosis (TB), a disease responsible for an estimated two million deaths each year. The findings, published in the March 21 online issue of Nature Chemical Biology, could lead to a potent TB therapy that would also prevent resistant TB strains from developing.

"This approach is totally different from the way any other anti-TB drug works," says William R. Jacobs, Jr., Ph.D., the study's senior author and professor of microbiology & immunology and of genetics at Einstein, as well as a Howard Hughes Medical Institute investigator. "In the past few years, extremely drug resistant strains of TB have arisen that can't be eliminated by any drugs, so new strategies for attacking TB are urgently needed."

Tuberculosis is caused by the bacterial species Mycobacterium tuberculosis. In searching for a new Achilles' heel for M. tuberculosis, Dr. Jacobs and colleagues focused on an enzyme called GlgE. Previous research had suggested that GlgE might be essential for the growth of TB bacteria. GlgE would also be an excellent drug target because there are no enzymes similar to it in humans or in the bacteria of the human gut.

The GlgE research revealed a previously unknown enzymatic pathway by which TB bacteria convert the sugar trehalose (consisting of two glucose molecules) into longer sugar molecules known as alpha glucans building blocks that are essential for maintaining bacterial structure and for making new microbes through cell division. GlgE was the third of four enzymes involved in this pathway leading to alpha glucans molecules.

Sure enough, when the researchers inhibited GlgE, the bacteria underwent "suicidal self-poisoning": a sugar called maltose 1-phosphate accumulated to toxic levels that damaged bacterial DNA, causing the death
'/>"/>

Contact: Deirdre Branley
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
2. Einstein researchers receive grants totaling $700,000 for innovative breast cancer research
3. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
4. In scientific first, Einstein researchers correct decline in organ function associated with old age
5. Einstein researchers develop a new way to study how breast cancer spreads
6. Einstein researchers develop technique to count messages made by single genes
7. Einstein scientists receive $10 million NIH grant
8. Empire State Stem Cell Board awards $12.7 million to Albert Einstein College of Medicine
9. Einstein and Pitt researchers develop new TB test that will dramatically cut diagnosis time
10. NIH funds research center for womens reproductive health at Einstein
11. Einstein researchers devise a fast and sensitive way to detect ricin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... ALLEN, Va. , May 28, 2015 /PRNewswire/ ... the release of a new report titled "Markets ... materials (reversible polymers, inorganic capsule and vascular systems, ... coatings) will grow to around $2.7 billion by ... deliverable from n-tech,s extensive coverage of smart materials. Other ...
(Date:5/22/2015)... , May 22, 2015 ... Market by Solution (2D, 3D, Thermal, Emotion, Forensic), by Software ... User (Government and Utilities, Consumer and Home) - Global ... to grow from $2.77 Billion in 2015 to $6.19 ... Browse 79 market data Tables and   ...
(Date:5/19/2015)... -- Fingerprint Cards (FPC) has received an order ... FPC1035 from one if its module partners. Deliveries are planned ... and the sensors will be used by smartphone manufacturers in ... hereby amount to 740 MSEK to date. In addition to ... a number of smaller orders not separately communicated amounting to ...
Breaking Biology News(10 mins):The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 2The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 3Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... In the perilous hours immediately after birth, a newborn ... from its mother. Under normal circumstances, newborns mount a ... This survival response involves a process of controlled breakdown ... has been well documented, the key mechanistic regulators of ...
... University today announced the discovery of an underlying genetic cause ... infancy that also affects millions of adults around the world ... were just published in PLoS ONE , a professional ... to this frustrating syndrome, which is difficult to treat and ...
... frequently causes gastric ulcers and is also one of the ... infection is also associated with another gastric cancer risk factor, ... Clinical Investigation , researchers led by Richard Peek at Vanderbilt ... -induced gastric cancer. Peek and colleagues found that low iron ...
Cached Biology News:Nutrient-sensing enzymes key to starvation response and survival in newborn mammals 2Researchers discover genetic basis for eczema, new avenue to therapies 2Ironing out the link between H. pylori infection and gastric cancer 2
(Date:6/2/2015)... Mass. , June 2, 2015 /PRNewswire/ ... a biotechnology company focused on discovering and ... of dermatology and ophthalmology, today announced that Dr. ... Officer, will present at the 23 rd ... six-day world congress will include in-depth presentations ...
(Date:6/2/2015)... 02, 2015 Through rare discovery of ... Yancy Corporation is enabling World Scientists to actually ... biological sample, displaying the full nature (position, shape, size, ... , Jeff Porter, Co-Founder of the Yancy Corporation, says, ... – rare. They come once in a lifetime, if ...
(Date:6/1/2015)... 02, 2015 Chosen for his ... Jack Uldrich has been selected as keynote speaker ... today. He will deliver his keynote: "Don't Stop ... delivered presentations to the American Medical Association, Blue ... Neurology, Alcetel-Lucent/Verizon Forum on Wireless Healthcare, United Healthcare, ...
(Date:6/1/2015)... RARITAN, N.J. , June 1, ... announced data from the Phase 3 multicenter study ... survival (PFS) with trabectedin (YONDELIS ® ) compared ... or leiomyosarcoma (LMS) previously treated with an anthracycline ... is the largest randomized Phase 3 study ever ...
Breaking Biology Technology:RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 4Scientists Eying Rare Discovery Of New Physics & Light Microscope Technology 2Futurist Jack Uldrich to Address the Future of Pharmaceuticals 2Trabectedin Improves Disease Control in Patients with Advanced Soft Tissue Sarcoma 2Trabectedin Improves Disease Control in Patients with Advanced Soft Tissue Sarcoma 3Trabectedin Improves Disease Control in Patients with Advanced Soft Tissue Sarcoma 4Trabectedin Improves Disease Control in Patients with Advanced Soft Tissue Sarcoma 5Trabectedin Improves Disease Control in Patients with Advanced Soft Tissue Sarcoma 6
... Madison, Wis. - Quintessence Biosciences , a ... one of its EVade cancer treatments, has been selected ... ,Quintessence said that pending a favorable preclinical safety assessment, ... Drug Administration an investigational new drug application in ...
... adison, Wis. - Five years removed from ... investors and questioning the value of the online world, ... The models are both progressive in their cutting-edge approach ... realities. , ,The picture of those business models ...
... - If you dropped the word sustainability in ... of them would have pegged you as an aging ... riding their bikes to work. , ,Today, sustainability still ... might stick around to talk because there's no avoiding ...
Cached Biology Technology:Web-centric entrepreneurs find models that attract investment 2Web-centric entrepreneurs find models that attract investment 3Web-centric entrepreneurs find models that attract investment 4Web-centric entrepreneurs find models that attract investment 5Re-engineering our economy to be sustainable and profitable 2Re-engineering our economy to be sustainable and profitable 3Re-engineering our economy to be sustainable and profitable 4
... polyclonal to JMJD2D ( Abpromise for ... Synthetic peptide conjugated to KLH derived ... Human JMJD2D.(Note: the amino acid sequence is ... Entrez Gene ID: 55693 ...
Rabbit polyclonal to JAK1 (phospho Y1022 + Y1023) ( Abpromise for all tested applications). entrezGeneID: 3716 SwissProtID: P23458...
Cytofix/Cytoperm Plus Kit with GolgiPlug 250 Tests...
The BD PhosFlow Fix Buffer I can be used for the simultaneous fixation and permeabilization of cells prior to intracellular staining. Applications: Intracellular Staining (Flow) Storage Temperature:...
Biology Products: