Navigation Links
Einstein researchers discover 2 new ways to kill TB
Date:3/21/2010

March 21, 2010 ─ (BRONX, NY) ─ Researchers at Albert Einstein College of Medicine of Yeshiva University have found two novel ways of killing the bacteria that cause tuberculosis (TB), a disease responsible for an estimated two million deaths each year. The findings, published in the March 21 online issue of Nature Chemical Biology, could lead to a potent TB therapy that would also prevent resistant TB strains from developing.

"This approach is totally different from the way any other anti-TB drug works," says William R. Jacobs, Jr., Ph.D., the study's senior author and professor of microbiology & immunology and of genetics at Einstein, as well as a Howard Hughes Medical Institute investigator. "In the past few years, extremely drug resistant strains of TB have arisen that can't be eliminated by any drugs, so new strategies for attacking TB are urgently needed."

Tuberculosis is caused by the bacterial species Mycobacterium tuberculosis. In searching for a new Achilles' heel for M. tuberculosis, Dr. Jacobs and colleagues focused on an enzyme called GlgE. Previous research had suggested that GlgE might be essential for the growth of TB bacteria. GlgE would also be an excellent drug target because there are no enzymes similar to it in humans or in the bacteria of the human gut.

The GlgE research revealed a previously unknown enzymatic pathway by which TB bacteria convert the sugar trehalose (consisting of two glucose molecules) into longer sugar molecules known as alpha glucans building blocks that are essential for maintaining bacterial structure and for making new microbes through cell division. GlgE was the third of four enzymes involved in this pathway leading to alpha glucans molecules.

Sure enough, when the researchers inhibited GlgE, the bacteria underwent "suicidal self-poisoning": a sugar called maltose 1-phosphate accumulated to toxic levels that damaged bacterial DNA, causing the death
'/>"/>

Contact: Deirdre Branley
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
2. Einstein researchers receive grants totaling $700,000 for innovative breast cancer research
3. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
4. In scientific first, Einstein researchers correct decline in organ function associated with old age
5. Einstein researchers develop a new way to study how breast cancer spreads
6. Einstein researchers develop technique to count messages made by single genes
7. Einstein scientists receive $10 million NIH grant
8. Empire State Stem Cell Board awards $12.7 million to Albert Einstein College of Medicine
9. Einstein and Pitt researchers develop new TB test that will dramatically cut diagnosis time
10. NIH funds research center for womens reproductive health at Einstein
11. Einstein researchers devise a fast and sensitive way to detect ricin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... study from UC San Francisco is the first to ... overtime and accelerate cellular aging, these negative effects may ... sleeping well. , "The study participants who exercised, ... than the ones who didn,t maintain healthy lifestyles, even ... author Eli Puterman, PhD, assistant professor in the department ...
(Date:7/28/2014)... U.S. Food and Drug Administration (FDA) for other purposes ... inside human cells, including those that cause Legionnaires, disease, ... mBio , the online open-access journal of the ... identifying non-antibiotic drugs that could one day help curb ... the list inhibit the growth of at least three ...
(Date:7/28/2014)... additional coral communities showing signs of damage from the Deepwater ... spill in the Gulf of Mexico. The discovery was made ... at Penn State University. A paper describing this work and ... of Mexico will be published during the last week of ... Proceedings of the National Academy of Sciences . , ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2New route to identify drugs that can fight bacterial infections 2Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2
... pays to be rare—think of a one-of-a-kind diamond, a ... , Now, new research suggests that being rare has ... University of Toronto Mississauga who in the 1980s discovered ... fruit flies, has identified the benefit of rarity in ...
... the La Jolla Institute for Allergy & Immunology have ... be reduced ?and in some cases eliminated ?through the ... the immune system. The research team’s findings, based ... implications for other chronic virus infections, such as hepatitis ...
... how ocean circulation is working in the current that ... from underwater volcanoes. The details are published in Nature ... Garabato of the National Oceanography Centre, Southampton (formerly based ... 'short-circuit' in the circulation of the world's oceans that ...
Cached Biology News:Survival of the rarest: Fruit flies shed light on the evolution of behavior 2LIAI scientists make important finding on cytomegalovirus transmission 2'Short-circuit' found in ocean circulation 2
(Date:7/29/2014)... G-CON Manufacturing Inc., the standard in ... a new leadership appointment designed to drive the company’s ... , Maik Jornitz, Chief Operating Officer of G-Con ... with leading the pioneering company through its next phase ... of development and look forward to providing our next ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The first ... a next generation approach to robotics. What sets Droidles ... patent pending technology that allows them to communicate, share ... wirelessly over the internet. , “The invention is the ... the little Droidles a life of their own, both ...
(Date:7/29/2014)... July 29, 2014 Eppendorf Centrifuge ... product selection. Eppendorf 5427 R is geared towards high-end ... – it is targeted towards work requiring high sample ... R as it compliments their extensive 16, 48, and ... of microcentrifuge tubes, PCR tubes, PCR strip tubes, and ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The prestigious ... of Congress was recently awarded to Juliana Hillis and ... MA, for their project, “From an Egg, Everything: America’s ... 3,000 final entries for the National History Day program ... 300 historians and educators in Washington, D.C. , The ...
Breaking Biology Technology:G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2International Pipette Distributor, Pipette.com Announces the Addition of the Eppendorf Centrifuge 5427 R to Their Product Portfolio 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3
... one of six states to receive a $50,000 grant ... network further into the Internet age. , ,Wisconsin's grant ... of Justice Assistance, which houses the Wisconsin Justice ... maintaining, promoting and coordinating automated justice information systems. , ...
... the learning acquired in the program but rather the blue-chip roster ... mythology goes, you can call on a fellow alum to help ... will be of value once again. , ,Though I can't say ... can attest to the power of alumni connections. , ,While I'm ...
... of health-care and business technology, announced a seven-year contract with ... Information System (MMIS). The new system is expected to be ... contracts EDS to implement its InterChange health system on the ... Services . The contract is worth approximately $189 million and ...
Cached Biology Technology:State receives grant for justice information sharing 2Pay attention to your alumni connections when job hunting 2Pay attention to your alumni connections when job hunting 3Pay attention to your alumni connections when job hunting 4State picks long-time vendor for $189m Medicaid information system 2
Rabbit polyclonal to Quinolinic acid ( Abpromise for all tested applications). Antigen: Synthetic quinolinic acid conjugated to bovine serum albumin....
Phospho-YAP (Ser127) Antibody Ship: Hot Store: -20 C...
Human Cell Line Slides...
Human Cell Line Slides...
Biology Products: