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Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
Date:10/16/2007

e DNA into chromosomes). The methylation (addition of a methyl group, CH3) of cytosine switches genes off, which can be associated with certain diseases such as cancer. The second key epigenetic mechanismmodifying histone proteinsalso helps to control whether or not a gene is expressed.

The technology were using will allow us to identify the genetic mutations responsible for the epigenetic dysregulation that results in human disease, added Dr. Greally. In doing so, we can then develop potential targets for treatment.

All the data generated by the ENCODE project will be deposited into public databases as soon as they are experimentally verified. As a result, researchers around the world will have free and rapid access to the data and will be able to pose new questions and gain new insights into how the human genome functions.


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Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

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