Navigation Links
Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
Date:10/16/2007

(BRONX, NY) A researcher at the Albert Einstein College of Medicine has been awarded a $1.5 million, three-year technology development grant from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health. Dr. John Greally, associate professor of medicine and of molecular genetics at Einstein, received one of six technology development grants awarded by the NHGRI as part of its ENCyclopedia Of DNA Elements (ENCODE) project.

Dr. Greally studies epigenetics, an emerging field that involves changes in gene expression that do not result from changes in DNA sequence. These epigenetic changes can be passed on from one cell generation to the next. The epigenetic regulation of genesturning them on and offis crucially important: Glitches in epigenetic control mechanisms, for example, have been found in every type of cancer that researchers have examined to date.

During his three-year project, Dr. Greally plans to develop new means of identifying patterns of epigenetic regulators in the human genome, gaining insights into how these epigenetic mechanisms control genes. Dr. Greally will team with Brad Bernstein, M.D., of Massachusetts General Hospital and Andi Gnirke, Ph.D., of Bostons Broad Institute to develop these new assays that are based on the use of high-throughput sequencing.

The high-throughput sequencer will allow us to generate billions of base pairs of DNA sequence information in each experiment, allowing us to study the epigenome at a level of resolution that has never previously been possible, said Dr. Greally, who is principal investigator for the team. Well be able to view things in greater detail and with greater accuracy than ever before.

The researchers will be developing high-throughput methods to analyze and map the two principal epigenetic control mechanisms: methylation of cytosine (one of four nucleic acids found in DNA) and modifications of histones (proteins that help to packag
'/>"/>

Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Einstein researchers identify new way that bacteria develop resistance to antibiotics
2. Einstein scientists discover how protein crucial for motion is synthesised at the right place in the cell
3. Feinstein researchers identify intelligence gene
4. Study by Einstein researchers could lead to a novel strategy for treating obesity
5. Einstein researchers take the pulse of a gene in living cells
6. Einstein researchers demonstrate a novel approach to treating AIDS
7. Einsteins tea leaves inspire new blood separation technique
8. Researchers discover way to make cells in the eye sensitive to light
9. Researchers find how protein allows insects to detect and respond to pheromones
10. Researchers Uncover Key Step In Manufacture of Memory Protein
11. U of M researcher examines newly emerging deadly disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... heard of the birds and the bees. But ... are being fertilized. The fertilization process for flowering ... between the male and female reproductive cells. New ... Heidelberg, and Munich, and including Carnegie,s Wolf Frommer, ... the chemical signaling process that guides flowering plant ...
(Date:8/21/2014)... use a previously unknown process for harvesting energy and ... a Penn State University scientist has discovered. The discovery ... plant growth, harvesting energy from the Sun, and understanding ... and other lakes worldwide. A paper describing the discovery ... edition of the journal Science on 21 ...
(Date:8/21/2014)... researchers from Beth Israel Deaconess Medical Center (BIDMC ) ... Most Influential Scientific Minds 2014," a comprehensive list ... web resource for science metrics and research performance analysis. ... most influential "are performing and publishing work that their ... science," according to a Thomson Reuters statement. Researchers were ...
Breaking Biology News(10 mins):Calcium and reproduction go together 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3
... date of genetic variation among chimpanzees has found that ... central and eastern—is underpinned by significant genetic differences, two ... most different human populations. , In the April ... the University of Chicago, Harvard, the Broad Institute and ...
... cells from being forced to devour themselves, removing one ... researchers at The University of Texas M. D. Anderson ... Cancer Research. , The protein tissue transglutaminase, known by ... at M. D. Anderson and elsewhere to be overexpressed ...
... termites can tell what sort of material their food is ... may lead to improvements in the control of feeding termites. ... and specially designed blocks made of wood and other materials, ... containing the most wood ?even though they could not touch ...
Cached Biology News:Gene study shows three distinct groups of chimpanzees 2Protein found to shield pancreatic cancer cells from self-destruction 2
(Date:8/21/2014)...  BioSpecifics Technologies Corp. (NASDAQ: BSTC ... collagenase-based products marketed as XIAFLEX ® (collagenase ... XIAPEX ® in the EU, today announced ... Phase 2a study of CCH for the potential ... results showed that all three doses of CCH ...
(Date:8/21/2014)... , August 21, 2014 ... http://www.researchandmarkets.com/research/3zh3q8/global_hormone ) has announced the addition of ...  report to their offering.       ... as hormone therapy, is a means of ... produced by the body. This type of ...
(Date:8/21/2014)... Mathematic studies at the Program for Evolutionary Dynamics ... Jeffrey Epstein VI Foundation , have shown that the ... elimination. These aggressive cells are the driver mutations that drive ... of what to look for when examining tumors, comes at ... can be extracted from biopsy, it,s very difficult to know ...
(Date:8/21/2014)... August 21, 2014 Ontotext S4 ... by Ontotext . Now the same enterprise ... of structured and unstructured data is available to start-ups ... of enterprise technology. Organizations that do not have resources ... management can use S4 since there is no need ...
Breaking Biology Technology:BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4
... A University of Colorado at Boulder team has developed ... used in nanotechnology devices like computer chips and solar ... Like current methods in the nanoengineering field, one color ... CU-Boulder Assistant Professor Robert McLeod of the electrical, computer ...
... Analytics and Utilization Review Services to Improve Safety ... APS Healthcare, a leading provider of specialty ... information company, have been selected by the New ... state,s Medicaid clinical best practice utilization review program. ...
... Cell Biosciences, Inc., a provider of nanoproteomic ... the launch of the Cell Biosciences CB1000 protein ... of cell signaling proteins. The CB1000 establishes a ... researchers studying signaling pathways in limited samples, such ...
Cached Biology Technology:Novel CU-Boulder technique shrinks size of nanotechnology circuitry 2APS Healthcare and Thomson Reuters to Manage New York State's Medicaid Clinical Best Practices Review Program 2APS Healthcare and Thomson Reuters to Manage New York State's Medicaid Clinical Best Practices Review Program 3APS Healthcare and Thomson Reuters to Manage New York State's Medicaid Clinical Best Practices Review Program 4Cell Biosciences Launches Next-Generation Protein Characterization System 2
Fujifilm Pictro-Color Process for sharp, clear reproduction comparable to silver-halide photography. Photorealistic 400 dpi quality. A4 and A5 output....
... PYREX low form culture flask is designed for culturing ... This flask has a heavy beaded rim to protect ... neck O.D. is 38mm and takes a No. 6.5 ... on a heat source smaller than the base of ...
... FRT-amp-FRT cassette is designed to ... The prokaryotic promoter gb2 driving the gene ... version of the Em7 promoter. It mediates ... Tn5 promoter. A synthetic polyadenylation signal terminates ...
... Application: Pyronin Y is most widely ... to selectively and differentially stain nucleic ... a dichromatic dye solution, Pyronin Y ... stains DNA green. Chem ...
Biology Products: