Navigation Links
Einstein researcher awarded prestigious cancer research grant
Date:5/12/2010

May 11, 2010 (BRONX, NY) Matthew Gamble, Ph.D., assistant professor of molecular pharmacology at Albert Einstein College of Medicine of Yeshiva University, has been awarded a $200,000 Kimmel Scholar Award. He is one of 15 U.S. scientists selected this year by the Kimmel Scholar program, created in 1997 to advance the careers of promising young scientists involved in cancer research. The $200,000 award will fund Dr. Gamble's innovative research for the next two years.

Dr. Gamble is exploring two families of proteins that interact abnormally in cancer, leading to increased cell division. The research could lead to more targeted drug treatments.

One protein family that Dr. Gamble is studying, called poly(ADP-ribose) polymerases, or PARPs, regulates DNA repair and gene expression, the process through which genes make proteins. Members of the other class of proteins all possess the same "macro domain" a stretch of amino acids that binds to poly(ADP-ribose), the molecule produced by PARPs. The interactions between these two families of proteins influence the ability of cancer cells to grow, but the mechanism is still unknown.

Drugs are now being developed that kill certain types of cancer cells (including breast and ovarian) by inhibiting PARPs, while leaving normal cells unscathed. However, scientists do not yet completely understand why these drugs are effective against some tumors but not others. Since levels of proteins with macro domains are often abnormally expressed in cancer cells, better understanding the interplay between macro domains and PARPs may allow doctors to test cancer patients' macro domain status to determine if they could benefit from taking a PARP inhibitor.

"This award will be crucial to learning how these proteins interact across the genome and how these interactions are disturbed in cancer," Dr. Gamble said.

The 33-year-old Dr. Gamble says that as a new principal investigator at Einstein, he has greatly benefited from his interactions with key faculty, including Susan Band Horwitz, Ph.D., and Charles Rubin, Ph.D., co-chairs of molecular pharmacology.

"Dr. Gamble's work in understanding the interaction between PARPs and macro domain proteins may lead to new treatments for cancer," said Dr. Horwitz. "He's an outstanding young scientist who is very collaborative, and we're fortunate to have recruited him."


'/>"/>

Contact: Deirdre Branley
sciencenews@aecom.yu.edu
718-430-2923
Albert Einstein College of Medicine
Source:Eurekalert  

Related biology news :

1. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
2. Einstein researchers receive grants totaling $700,000 for innovative breast cancer research
3. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
4. In scientific first, Einstein researchers correct decline in organ function associated with old age
5. Einstein researchers develop a new way to study how breast cancer spreads
6. Einstein researchers develop technique to count messages made by single genes
7. Einstein scientists receive $10 million NIH grant
8. Empire State Stem Cell Board awards $12.7 million to Albert Einstein College of Medicine
9. Einstein and Pitt researchers develop new TB test that will dramatically cut diagnosis time
10. NIH funds research center for womens reproductive health at Einstein
11. Einstein researchers devise a fast and sensitive way to detect ricin
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Einstein researcher awarded prestigious cancer research grant
(Date:3/20/2017)... 2017 PMD Healthcare announces the release of ... Management System (WMS), a remote, real-time lung health monitoring ... Healthcare is a Medical Device, Digital Health, and Chronic ... creating innovative solutions that empower people to improve their ... PMD developed the first ever personal spirometer, Spiro PD, ...
(Date:3/9/2017)... , Australia , March 9, 2017 ... data at the prestigious World Lung Imaging Workshop at ... Andreas Fouras , was invited to deliver the latest ... medicine. This globally recognised event brings together leaders at ... the latest developments in lung imaging. ...
(Date:3/7/2017)... LAKE CITY , March 7, 2017   ... that help top global companies identify the best talent, ... as Chief Sales Officer (CSO) and Diana ... Kucer,s appointments round out a seasoned executive team poised to ... and beyond, building on a year of record bookings ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... 27, 2017  The global market for clinical ... to a new report from Kalorama Information.  In ... performed to evaluate disease progression, monitor drug treatment ... reasons.  The healthcare market research firm,s report, ... an overview of the medical laboratory industry and ...
(Date:3/27/2017)... ... ... PMG Research is pleased to announce its participation in the 2nd ... Boston on April 3-4, 2017. The CTC conference focuses on how the industry is ... closer to the patient. Clinical Trial Collaborations also will present an inaugural conference on ...
(Date:3/27/2017)... 2017 DarioHealth Corp. (NASDAQ: DRIO), a leading ... data solutions, today announced that it is now offering ... U.S. consumers who want to have their DarioHealth products ... strategic alliance agreements with partners across the U.S. who ... if approved, will supply and bill the customer,s insurance ...
(Date:3/24/2017)... and ROCKVILLE, Md. , March 24, ... Maxwell Biotech Venture Fund (MBVF), today announced positive results ... to the standard drug therapy regimen in patients with ... molecule drug discovered by scientists at Sequella, Inc. ( ... of Health. A total of 140 ...
Breaking Biology Technology: